New dammarane-type triterpenoid glycosides from Gynostemma burmanicum

Abstract

The chemical composition of Gynostemma burmanicum King ex Chakrav. was investigated for the first time in this study. Nine dammarane glycosides (1-9) were isolated from the EtOH extract of the aerial parts of G. burmanicum. Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The new compounds were 3β,20Sdihydroxydammar-24-ene-3-O-β-D-glucopyranosyl-20-O-[β-D-xylopyranosyl-(1→6)-β-Dglucopyranoside] (1), 3β,12β,20S-trihydroxydammar-24-ene-3-O-β-D-xylopyranosyl-20-O-[β-Dxylopyranosyl-(1→6)-β-D-glucopyranoside] (2), and 12-oxo-3β,20S-dihydroxydammar-24-ene-3-O-[β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-[β-D-xylopyranosyl-(1→6)-β-Dglucopyranoside] (3).

Ten New Dammarane-Type Saponins with Hypolipidemia Activity from a Functional Herbal Tea—Gynostemma pentaphyllum

“…It consists of numerous chemical components, such as saponins, vitamins, polysaccharides, flavonoids, and amino acids [ 12 , 13 ]. Previous studies have shown that Gypenoside is a marker component in this plant, and its main chemical components have excellent anti-hyperlipidemia, anti-oxidative, anti-inflammatory, anti-tumor, and other biological activities [ 11 , 14 , 15 , 16 , 17 ]. In view of its good pharmacological activity and edible value, the chemical composition aroused our research group’s interest.…”