New Daily Persistent Headache (NDPH): Unraveling the Complexities of Diagnosis, Pathophysiology, and Treatment

Sadeghpour, Majid; Abdolizadeh, Ali; Yousefi, Pourya; Rastegar-Kashkouli, Ali; Chitsaz, Ahmad

doi:10.1007/s11916-023-01161-y

Cited by 2 publications

(5 citation statements)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OnabotulinumtoxinA has shown efficacy in the reduction of both the severity and frequency of headache in adults with NDPH, but there are no studies demonstrating efficacy in the pediatric population [ 19 , 42 ]. However, given the reduction in headache frequency and intensity seen in children with chronic migraine, along with its excellent safety profile [ 43 ], it is a reasonable option for patients who have not seen benefit from other therapies.…”

Section: Resultsmentioning

confidence: 99%

“…Another study showed that DHE infusions resulted in at least some improvement for most patients with refractory headache regardless of headache type [ 13 ]. A case study showed a response to intravenous lidocaine in one adolescent who had not responded to previous treatments [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…There has been a report of pain relief after osteopathic manipulative treatment [ 8 ] and another of improvement in NDPH frequency and intensity in two patients after the initiation of riboflavin [ 46 ]. Non-invasive neuromodulation is another favorable option due to its tolerable side effect profile, although studies are needed [ 19 ]. While there are no dietary or lifestyle guidelines developed specifically for patients with NDPH, given the significant overlap in clinical features and treatment options with chronic migraine, it is reasonable to extend similar recommendations focusing on stress management, sleep hygiene and behavioral interventions, good hydration, and regular healthy meals [ 19 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…Non-invasive neuromodulation is another favorable option due to its tolerable side effect profile, although studies are needed [ 19 ]. While there are no dietary or lifestyle guidelines developed specifically for patients with NDPH, given the significant overlap in clinical features and treatment options with chronic migraine, it is reasonable to extend similar recommendations focusing on stress management, sleep hygiene and behavioral interventions, good hydration, and regular healthy meals [ 19 , 47 ]. Likewise, as co-morbid depression and anxiety is commonly seen in patients with NDPH, mental health screening is needed so that appropriate multidisciplinary treatment can be initiated.…”

Section: Resultsmentioning

confidence: 99%

“…NDPH, a subtype of CDH, occurs in approximately 0.003% of the overall population [18]. Within the CDH population at tertiary centers, the prevalence of NDPH in children and adolescents ranges from 0.9 to 35%, compared to 1.7 to 10.8% in adults [19]. It maintains a female predominance throughout life, with a 2.5:1 female/male ratio in adults and a 1.8:1 female/male ratio in children and adolescents, and has an earlier age at onset in females (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) than in males (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) [2].…”

Section: Epidemiologymentioning

confidence: 99%

See 4 more Smart Citations

New Daily Persistent Headache in the Pediatric and Adolescent Population: An Updated Review

Kalika,

Monteith

2024

Life

View full text Add to dashboard Cite

Purpose of review: New daily persistent headache (NDPH) is a primary headache disorder characterized by the sudden onset of continuous pain and its intractability to treatment. It is more prevalent in the pediatric population than the adult population, but remains understudied and underdiagnosed. The purpose of the current article is to provide a current overview of new daily persistent headache in the pediatric and adolescent population, including history, pathophysiology, clinical findings, current and emerging treatment options, and the results of recent studies and meta-analyses. Recent findings: Despite recent studies and meta-analyses showing significant phenotypic overlap between chronic migraine and NDPH in the pediatric population, multiple recent studies have come to conflicting conclusions about the overlap of medication overuse in headache and pediatric NDPH. Recent studies reveal alterations in neuroimaging, particularly in functional connectivity, in patients with NDPH. Patients frequently remain treatment-refractory even to medications that have historically proven helpful in this population; however, new treatment options, including calcitonin gene-related peptide (CGRP) monoclonal antibodies, may be more effective. Summary: NPDH remains a perplexing and difficult-to-manage condition for both children and adults. Despite a higher prevalence in the pediatric population, there are relatively few studies to guide the evaluation and treatment of NDPH in pediatric and adolescent patients. Early treatment, both pharmacological and non-pharmacological, should be employed to reduce disability. Overall, further studies are needed to better understand pathogenesis and to identify more effective therapeutic strategies, both pharmacological and non-pharmacological.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%