New cytotoxic secondary metabolites against human pancreatic cancer cells from the Hypericum perforatum endophytic fungus Aspergillus terreus

Deng, Mengyi; Li, Tao; Qiao, Yuben; Sun, Wenping; Xie, Shuangshuang; Shi, Zhengyi; Qi, Changxing; Zhang, Yonghui

doi:10.1016/j.fitote.2020.104685

Cited by 14 publications

(15 citation statements)

References 16 publications

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“… Pinellia ternate (T) China Xin et al. (2019) Asperlactone H (109) A-549 23.3 ± 2.01 μM (−)-Asperteretone E (110) AsPC-1 9.50 μM Aspergillus terreus Hypericum perforatum (T) China Deng et al. (2020) SW1990 11.7 μM PANC-1 9.80 μM (+)-Asperteretone E (111) AsPC-1 9.90 μM SW1990 10.3 μM PANC-1 15.6 μM Hispidulactone F (112) HepG2 61.05 μM Chaetosphaeronema hispidulum (TS-8-1) Dessert plant (T) China Zheng et al.…”

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

“…Compounds (110) and (111) exhibited cytotoxic activity against human pancreatic cancer cells AsPC-1, SW1990 and PANC-1 cell line with IC 50 values of 9.5, 11.7, 9.8 μM and 9.9, 10.3, 15.6 μM, respectively. Both the compounds remain inactive against HeLa and SW480 cancer cell lines, while other compounds were inactive against all tested cell lines ( Deng et al., 2020 ). Hispidulactone F (112) , a novel metabolite was separated from the EtOAc extract of dessert plant associated endophytic fungus Chaetosphaeronema hispidulum (TS-8-1) and showed antiproliferative activity against HepG2 cells with IC 50 of 61.05 μM by the cell counting kit-8 (CCK-8) assay ( Zheng et al., 2020 ).…”

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

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Endophytic fungi: A treasure trove of novel anticancer compounds

Prajapati

Goswami

Rawal

2021

Current Research in Pharmacology and Drug Discovery

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Cancer is a multifactorial disease with a convoluted genesis and progression. The emergence of multidrug resistance to presently be offered drug and relapse is by far, the most critical concern to tackle this deteriorating disease. Henceforth, there is undeniably an inflated necessity for safe, promising, and less harmful new anticancer drugs. Natural compounds from various sources like plants, animals, and microorganisms have occupied a center stage in drug discovery due to their tremendous chemical diversity and potential as therapeutic agents. Endophytic microbes are symbiotically associated with plants and have been proven to produce novel or analogues of host bioactive metabolites exhibiting a variety of biological activities including anticancer activity. This review emphasizes on structurally diverse unprecedented anticancer natural compounds that have been reported exclusively from endophytic fungi from 2016 to 2020. It covers chemical nature of metabolites, its fungal source associated with terrestrial, as well as marine plants and anticancer activity based on their cytotoxicity profile against various cancer cell lines. Many of these fungal metabolites with promising anticancer activity can be used as lead molecules for in silico experiments and deserve special attention from scientists for further in vitro and clinical research.

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Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

Section: Cytotoxic Secondary Metabolites From Endophytic Fungimentioning

confidence: 99%

Endophytic fungi: A treasure trove of novel anticancer compounds

Prajapati

Goswami

Rawal

2021

Current Research in Pharmacology and Drug Discovery

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“…Finally, six polycyclic polyprenylated acylphloroglucinols (PPAPs), identified as hyperisampsins H-M (1-6), were separated from the aerial portions of Hypericum sampsonii, together with five already recognized analogs (7)(8)(9)(10)(11). Compounds 1-7 were studied for their cytotoxic actions against a group of human tumor cell lines in vitro (HL60 and NB4), of which 3, 4, and 6 demonstrated relevant cytotoxic actions with IC50 values oscillating from 0.56 to 3.00 µM.…”

Section: Figure 2 Activity Of Hyperforin (Hf)mentioning

confidence: 99%

“…It also displays an ample variety of other different biological actions, such as hypotensive, analgesic, anti-infective, anti-oxidant, and spasmolytic abilities (Figure 1) [3][4][5][6][7]. However, recent investigations highlighted that this species could be advantageous for the cure of other pathological situations, such as trigeminal neuralgia [8,9], and in the treatment of cancer [10,11]. infective, anti-oxidant, and spasmolytic abilities (Figure 1) [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…infective, anti-oxidant, and spasmolytic abilities (Figure 1) [3][4][5][6][7]. However, recent investigations highlighted that this species could be advantageous for the cure of other pathological situations, such as trigeminal neuralgia [8,9], and in the treatment of cancer [10,11]. The genus Hypericum includes other species utilized as medicine in diverse regions of the world.…”

Section: Introductionmentioning

confidence: 99%

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Antiproliferative Effects of St. John’s Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies

Allegra

Tonacci

Spagnolo

et al. 2020

IJMS

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Hypericum is a widely present plant, and extracts of its leaves, flowers, and aerial elements have been employed for many years as therapeutic cures for depression, skin wounds, and respiratory and inflammatory disorders. Hypericum also displays an ample variety of other biological actions, such as hypotensive, analgesic, anti-infective, anti-oxidant, and spasmolytic abilities. However, recent investigations highlighted that this species could be advantageous for the cure of other pathological situations, such as trigeminal neuralgia, as well as in the treatment of cancer. This review focuses on the in vitro and in vivo antitumor effects of St. John’s Wort (Hypericum perforatum), its derivatives, and other Hypericum species in hematologic malignancies. Hypericum induces apoptosis in both myeloid and lymphoid cells. Other Hypericum targets include matrix metalloproteinase-2, vascular endothelial growth factor, and matrix metalloproteinase-9, which are mediators of cell migration and angiogenesis. Hypericum also downregulates the expression of proteins that are involved in the resistance of leukemia cells to chemotherapeutic agents. Finally, Hypericum and its derivatives appear to have photodynamic effects and are candidates for applications in tumor photodynamic therapy. Although the in vitro studies appear promising, controlled in vivo studies are necessary before we can hypothesize the introduction of Hypericum and its derivatives into clinical practice for the treatment of hematologic malignancies.

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