New Cytotoxic Monotetrahydrofuran Annonaceous Acetogenins from Annona muricata

Abstract

Three new monotetrahydrofuran annonaceous acetogenins, muricin H (1), muricin I (2), and cis-annomontacin (3), along with five known acetogenins, annonacin, annonacinone, annomontacin, murisolin, and xylomaticin, were isolated from the seeds of Annona muricata. Additionally, two new monotetrahydrofuran annonaceous acetogenins, cis-corossolone (4) and annocatalin (5), together with four known ones, annonacin, annonacinone, solamin, and corossolone, were isolated from the leaves of this species. The structures of all new isolates were elucidated and characterized by spectral and chemical methods. These new acetogenins exhibited significant activity in in vitro cytotoxic assays against two human hepatoma cell lines, Hep G(2) and 2,2,15. Compound 5 showed a high selectivity toward the Hep 2,2,15 cell line.

Quantitative Assessment of the Relative Antineoplastic Potential of the n-butanolic Leaf Extract of Annona Muricata Linn. in Normal and immortalized Human Cell Lines

“…Furthermore, the leaves of the plant are found to be anti-spasmodoic, hypotensive and are rich in annonaceous acetogenins (Gouemo et al, 2003;Yuan et al, 2003). Various other plants from this family have also been reported for their cytotoxic potential (Liaw et al, 2002;Ye et al, 2002;Pardhasaradhi et al, 2005;Magadula et al, 2009).…”

Possible mechanisms of action of the hypotensive effect ofAnnona muricata(soursop) in normotensive Sprague–Dawley rats

“…muricata is found widely in the West Indies, South and Central America, tropical West Africa, and Asia. In the West Indies, various parts of the plant, including the leaves, bark and roots have been used to treat disease conditions such as diabetes (Adeyemi et al, 2008(Adeyemi et al, , 2010 A. muricata include its anticancer (Oberlies et al, 1997;Liaw et al, 2002), antibacterial and antifungal (Takahashi et al, 2006) actions, as well as, its antinociceptive and anti-inflammatory effects (de Sousa et al, 2010). Phytochemical screening of the leaves of A. muricata has shown it to consist of alkaloids such as reticuline, coreximine, coclarine and anomurine (Leboeuf et al, 1981(Leboeuf et al, , 1982, annomuricin E, annomuricin C, muricatocin C, gigantetronenin and muricapentocin with antioxidant and antitumor properties (Wu et al, 1995;Kim et al, 1998;Luna et al, 2006;Baskar et al, 2007), as well as, essential oils such as β-caryophyllene, δ-cadinene, epi-α-cadinol and α-cadinol (Pelissler et al, 1994;Kossouoh et al, 2007).…”

Influence of different extraction conditions on antioxidant properties of soursop peel

“…The peel of the soursop is known to have antileishmanial activity (Jaramillo et al, 2000). Other studies also reported that the seeds of the soursop demonstrate strong anticancer and anti-tumor properties (Li et al, 2001;Liaw et al, 2002). Due to the higher nutritional values of soursop peel, this peel should be investigated for its antioxidant properties rather than the seeds.…”