New Cyclodextrin Hydrogels Cross-Linked with Diglycidylethers with a High Drug Loading and Controlled Release Ability

Rodrı́guez-Tenreiro, Carmen; Alvarez‐Lorenzo, Carmen; Rodríguez‐Pérez, Ana I.; Torres‐Labandeira, Juan J.

doi:10.1007/s11095-005-8924-y

Cited by 107 publications

(80 citation statements)

References 48 publications

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“…Generally, increased affinity between the drug and the type of CD correlated with slower release. [107] Release of other drugs from similar systems were also examined (e.g., ketoconazole [108] and diclofenac [109] ).…”

Section: Directly Crosslinked CD Hydrogelsmentioning

confidence: 99%

Affinity‐Based Drug Delivery

Wang

Recum

2010

Macromolecular Bioscience

169

146

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Affinity-based drug delivery systems utilize interactions between the therapeutic drug and the delivery system to manipulate drug loading and to control drug release. In this paper, affinity-based drug delivery system syntheses, types of therapeutic factors delivered, and delivery system loading and release are discussed in detail. The paper is divided into three subsections, based on the type of delivery system: molecular imprinting systems, growth-factor delivery, and cyclodextrin-based delivery. The objective of this paper is to examine the current state of research, highlight the breakthroughs and challenges, point out potential impacts of this relatively new technology, and explore future developmental areas.

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Section: Directly Crosslinked CD Hydrogelsmentioning

confidence: 99%

Affinity‐Based Drug Delivery

Wang

Recum

2010

Macromolecular Bioscience

169

146

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“…A different approach consists of designing synthetic networks with domains capable of mimicking the recognition features of the biological macromolecules. Various semisynthetic ringtype substances, such as crown ethers, cryptates, cyclophanes, or cyclodextrins, can host in their cavity certain molecules forming inclusion complexes [49][50][51][52][53]. The selectivity of the interactions with these materials is conditioned by the size of the cavities and the arrangement of their chemical groups.…”

Section: Molecule-responsive and Imprinted Systemsmentioning

confidence: 99%

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Álvarez-Lorenzo

Puga

2012

Biomimetic Approaches for Biomaterials Development

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“…This property occurs in both cyclodextrins and cyclodextrin derivatives, their polymers included. Between the multitude of substances included in cyclodextrins or in their polymeric gels, mention should be made of: drugs, [2][3][4] water pollutants such as b-naphthol, 5 phenolic derivatives, 6 aromatic compounds, 7,8 various dyes, [9][10][11][12] all providing a versatile method for the protection of the environment by waste water treatment. 13 Other CyD-based hydrogels were synthesized and tested for multidrug delivery 14 or/and controlled release systems.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin‐anionic polysaccharide hydrogels: Synthesis, characterization, and interaction with some organic molecules (water pollutants, drugs, proteins)

Mocanu¹,

Mihai²,

Lecerf³

et al. 2009

J of Applied Polymer Sci

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Hydrogel microparticles have been prepared through cocrosslinking of cyclodextrin and of anionic carboxymethyl or sulfopropyl pullulan with a new bifunctional reagent: 3-(glycidoxypropyl)trimethoxysilane. This reagent forms crosslinking both through grafting with the epoxy end on the OH polysaccharide and through hydrolysis and condensation of the methoxy silane groups from the other end. Samples of cyclodextrin/anionic polysaccharides with various amounts of crosslinking agent were prepared. Characterization of the hydrogel microparticles considered the water swelling behavior, porosity measurements, retention of biologically active substances, which can occur by their inclusion in cyclodextrin inner cavities and in the pores of hydrogels, as well as through the electrostatic forces toward anionic polyelectrolyte charges. Their improved retention of various organic molecules as water pollutants, drugs, enzymes, recommend them as chromatographic supports, supports for the separation/immobilization of enzymes or for controlled release systems.

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New Cyclodextrin Hydrogels Cross-Linked with Diglycidylethers with a High Drug Loading and Controlled Release Ability

Abstract: HPbetaCD hydrogels with good mechanical properties and tunable loading and release ability can be obtained by direct cross-linking with EGDE.

Cited by 107 publications

References 48 publications

Affinity‐Based Drug Delivery

Affinity‐Based Drug Delivery

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Cyclodextrin‐anionic polysaccharide hydrogels: Synthesis, characterization, and interaction with some organic molecules (water pollutants, drugs, proteins)

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