New cyclic glycolipids from Silene succulenta promote in vitro MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and in silico mitotic Mps1/TTK inhibition

Badawy, Shawky Z.A.; Hassan, Ahmed R.; Elkousy, Rawah H.; wafa, Salwa A. Abu El; Mohammad, Atta

doi:10.1039/d3ra01793a

RSC Adv.

2023

DOI: 10.1039/d3ra01793a

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New cyclic glycolipids from Silene succulenta promote in vitro MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and in silico mitotic Mps1/TTK inhibition

Shawky Z.A. Badawy

Ahmed R. Hassan

Rawah H. Elkousy

et al.

Abstract: S. succulenta may be effective in the treatment of breast cancer (MCF-7). In addition, these findings suggest that the isolated new cyclic glycolipids using a bioactive-guided approach can be used as potential antitumour breast cancer agents.

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2024

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Sticky business: the intricacies of acylsugar biosynthesis in the Solanaceae

Vendemiatti,

Nowack,

Peres

et al. 2024

Phytochem Rev

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Plants display tremendous chemical diversity. Like all organisms, they possess a core set of metabolites for growth and development. However, plants are notorious for their specialized chemical repertoire. Biologically active specialized metabolites enable plants to interact with their environment and provide humans with diverse medicines. Specialized metabolites are derived from core metabolites, often using enzymes that evolved from core pathways in a lineage-specific manner. Biochemical understanding of plant specialized metabolic pathways provides insight into the evolutionary origins of chemical diversity and tools for engineering the production of biologically active metabolites. Acylsugars are a class of specialized metabolites occurring widely in the Solanaceae and other plant families where they contribute to fitness. Although assembled from simple core metabolic precursors, sugars and acyl chains, tremendous acylsugar structural diversity is observed across the Solanaceae family. Enzymes that catalyze the esterification of acyl chains to sugar cores have been well characterized from phylogenetically diverse species, and their biochemical diversity contributes to acylsugar structural variation. The upstream metabolic pathways that provide the acyl chain precursors also contribute to acylsugar structural variation. Yet, biochemical and genetic understanding of these upstream biosynthetic pathways is less well known. Here, we focus on recent advances in acyl chain biosynthesis and elongation pathways, the subcellular distribution of acylsugar biosynthesis, and how biochemical innovations in acylsugar biosynthesis contribute to structural diversity specifically focusing on Solanaceae-type acylsugars.

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Sticky business: the intricacies of acylsugar biosynthesis in the Solanaceae

Vendemiatti,

Nowack,

Peres

et al. 2024

Phytochem Rev

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New cyclic glycolipids from Silene succulenta promote in vitro MCF-7 breast carcinoma cell apoptosis by cell cycle arrest and in silico mitotic Mps1/TTK inhibition

Abstract: S. succulenta may be effective in the treatment of breast cancer (MCF-7). In addition, these findings suggest that the isolated new cyclic glycolipids using a bioactive-guided approach can be used as potential antitumour breast cancer agents.

Cited by 1 publication

References 53 publications

Sticky business: the intricacies of acylsugar biosynthesis in the Solanaceae

Sticky business: the intricacies of acylsugar biosynthesis in the Solanaceae

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