New Crystalline Salts of Nicotinamide Riboside as Food Additives

Abstract

NR+ is a highly effective vitamin B3 type supplement due to its unique ability to replenish NAD+ levels. While NR+ chloride is already on the market as a nutritional supplement, its synthesis is challenging, expensive, and low yielding, making it cumbersome for large-scale industrial production. Here we report the novel crystalline NR+ salts, d/l/dl-hydrogen tartrate and d/l/dl-hydrogen malate. Their high-yielding, one-pot manufacture does not require specific equipment and is suitable for multi-ton scale production. These new NR+ salts seem ideal for nutritional applications due to their bio-equivalence compared to the approved NR+ chloride. In addition, the crystal structures of all stereoisomers of NR+ hydrogen tartrate and NR+ hydrogen malate and a comparison to the known NR+ halogenides are presented.

Polymorphism of Nicotinamide Riboside Chloride and Crystal Structure Determination of the Most Stable Crystalline Form

“…There is always an opportunity to discover a more stable form during further crystallization experiments. While ongoing crystallization study continues to identify novel crystalline form of NR-Cl, other substitute products, including new crystalline NR organic salts [12], NR prodrugs [13] and nicotinamide mononucleotide (NMN) as an alternative NAD + precursor [14], have also been under investigations in order to achieve optimal physicochemical properties.…”