New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications

Chare, Leone; Hodges, John R.; Leyton, Cristian E.; McGinley, Ciara V.; Tan, Rachel; Kril, Jillian J.; Halliday, Glenda M.

doi:10.1136/jnnp-2013-306948

Cited by 203 publications

(193 citation statements)

References 33 publications

(40 reference statements)

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“…PiB PET imaging was included as a proxy measure of AD pathology and was available for the majority of lvPPA patients, but only half of svPPA patients. For PPA patients with available PiB imaging, however, all lvPPA were found to be PiB-positive while svPPA were PiB-negative, consistent with expected pathology [8] and interpretation of current imaging findings. All patient and control follow-up assessments occurred within a 2-month margin of the 1-year timepoint, representing genuine longitudinal cognitive and neural change.…”

Section: Discussionmentioning

confidence: 62%

“…Of all PPA subtypes, lvPPA and svPPA appear to show the most homogenous clinico-pathological mapping, attributed to either AD or FTLD-TDP, respectively [8]. The impact of this distinction in pathology can be clearly seen in the localization and degree of structural abnormality in lvPPA and svPPA.…”

Section: Introductionmentioning

confidence: 88%

“…Pathological diagnosis across all PPAs is less clear with the presence of tau and TAR-DNAbinding protein 43 (TDP-43) pathological subtypes of frontotemporal lobar degeneration (FTLD) [7], and Alzheimer's disease (AD) pathology reported in each variant [8][9][10]. Of all PPA subtypes, lvPPA and svPPA appear to show the most homogenous clinico-pathological mapping, attributed to either AD or FTLD-TDP, respectively [8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Divergent Longitudinal Propagation of White Matter Degradation in Logopenic and Semantic Variants of Primary Progressive Aphasia

Leyton

Hodges

et al. 2015

JAD

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Abstract.Background: Clinico-pathological distinction of primary progressive aphasia (PPA) can be challenging at clinic presentation. In particular, cross-sectional neuroimaging signatures across the logopenic (lvPPA) and semantic (svPPA) variants are difficult to establish, with longitudinal profiles showing greater divergence. Objective: Assess longitudinal propagation of white matter degradation in lvPPA and svPPA to determine disease progression over time, and whether this reflects distinct underlying pathology. Method: A cohort of 27 patients with dementia (12 lvPPA; 15 svPPA) and 12 healthy controls were assessed at baseline and 1-year follow-up on the Addenbrooke's Cognitive Examination-Revised and Sydney Language Battery. Diffusion weighted images were collected at both time-points and analyzed for longitudinal white matter change using DTI-TK and TBSS. Results: LvPPA patients showed a significant decline in naming and repetition, over 1 year, while svPPA patients declined in naming and comprehension. Longitudinal imaging revealed widespread bilateral degradation of white matter tracts in lvPPA over a 1-year period with early involvement of the left posterior inferior longitudinal fasciculus (ILF). SvPPA demonstrated focal left lateralized white matter degradation involving the uncinate fasciculus (UF) and anterior ILF, propagating to the right UF with disease progression. Conclusions: LvPPA and svPPA cohorts showed distinct longitudinal cognitive and white matter profiles. We propose differences in multi-centric and focal white matter dysfunction in lvPPA and svPPA, respectively, reflect underlying pathological differences. The clinical relevance of white matter degradation and mechanisms underlying disease propagation are discussed.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Divergent Longitudinal Propagation of White Matter Degradation in Logopenic and Semantic Variants of Primary Progressive Aphasia

Leyton

Hodges

et al. 2015

JAD

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“…Some people with ALS also have frontotemporal dementia (FTD) while others have lesser degrees of cognitive impairment [2]. Some of the overlap between ALS and FTD is associated with the presence of a C9orf72 gene mutation [3,4].…”

Section: Accepted Manuscript Introductionmentioning

confidence: 99%

Screening for cognitive and behavioural impairment in amyotrophic lateral sclerosis: Frequency of abnormality and effect on survival

Alruwaili

Henderson

et al. 2017

Journal of the Neurological Sciences

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“…Several conditions may mimick bvFTD due to their overlapping clinical presentation, such as, e.g. Alzheimer's disease (AD) [2], vascular cognitive impairment [3], particularly in patients with subcortical vascular lesions [4,5], mixed dementia [6] and also psychiatric conditions [7,8]. Sporadic cerebral amyloid angiopathy (SCAA) is an important clinical entity which is present in up to 40% of elderly brains and 80% or more in patients with concomitant Alzheimer's disease [9,10].…”

Section: Introductionmentioning

confidence: 99%

Cerebral Amyloid Angiopathy or Frontotemporal Dementia? A Case Study

Benke¹,

Scherfler²,

Karner³

et al. 2017

J Alzheimers Dis Parkinsonism

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New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications

Cited by 203 publications

References 33 publications

Divergent Longitudinal Propagation of White Matter Degradation in Logopenic and Semantic Variants of Primary Progressive Aphasia

Divergent Longitudinal Propagation of White Matter Degradation in Logopenic and Semantic Variants of Primary Progressive Aphasia

Screening for cognitive and behavioural impairment in amyotrophic lateral sclerosis: Frequency of abnormality and effect on survival

Cerebral Amyloid Angiopathy or Frontotemporal Dementia? A Case Study

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