New coronoviral infection (COVID-19) combined with tuberculosis in patients at late stages of HIV infection with immunodeficiency

Мишина, А. В.; Мишин, В. Ю.; Ergeshov, Atajan; Sobkin, A. L.; Сергеева, Н. В.; Pilipenko, S. V.; Romanov, Vladimir

doi:10.22328/2077-9828-2021-13-1-80-87

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…Данные о сочетании этих трех инфекций в литературе немногочисленны, количество зарегистрированных случаев невелико, а полученные данные противоречивы [2,9,14,15 Всем пациентам был утвержден режим химиотерапии согласно клиническим рекомендациям «Туберкулез у взрослых МЗ РФ 2020 г.» с учетом теста на лекарственную чувствительность МБТ и переносимости пациентом ПТП.…”

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Clinical and laboratory specific parameters of COVID-19 in patients with TB/HIV co-infection

Alzhanov

Pyatibratova

Krasnov

et al. 2022

Tuberk. bolezni lëgk.

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The objective: to study clinical and laboratory specific parameters of the COVID-19 course in patients with TB/HIV co-infection, to analyze changes in the lungs caused by COVID-19 in patients with pulmonary tuberculosis and concurrent HIV infection.Subjects and Methods. 68 HIV-infected patients aged 18-66 years old were included in the study, they all were admitted to the Novosibirsk State Regional Clinical Tuberculosis Hospital, Novosibirsk, with confirmed COVID-19 from May 2020 to May 2021. Clinical manifestations, CD4 count and HIV RNA level, and the presence of secondary infections were assessed.Results. In patients with severe and profound immunodeficiency, coronavirus infection was more often mild to moderate, and in immunocompetent patients – moderate to severe. However, patients with profound immunodeficiency were at greater risk of an adverse outcome due to lymphohematogenic progression of tuberculosis and concurrent opportunistic infections.Conclusion. When diagnosing and treating COVID-19 in patients with comorbid HIV infection and tuberculosis, it is important to consider the form of tuberculosis and CD4+ count.

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Clinical and laboratory specific parameters of COVID-19 in patients with TB/HIV co-infection

Alzhanov

Pyatibratova

Krasnov

et al. 2022

Tuberk. bolezni lëgk.

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Epidemiology and course of infectious diseases during the COVID-19 pandemic. Report 1. HIV infection, hepatitis c and tuberculosis

Belyakov

Боева

Загдын

et al. 2022

Russian Journal of Infection and Immunity

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Pathological conditions of various natures are capable of mutual aggravation, significantly affecting the overall burden of the disease, its manifestations and severity. This analytical review is devoted to the interaction between pathogens of socially significant infections human immunodeficiency viruses (HIV), hepatitis C, Mycobacterium tuberculosis and SARS-CoV-2. Foreign and own data covering the issues of syndemia and interference of pathogens are presented. The results of epidemiological analysis in the North-Western Federal District (NWFD) are presented, which demonstrated the absence of a significant impact of the pandemic caused by a new coronavirus infection (COVID-19) on the epidemic incidence of HIV, viral hepatitis C or tuberculosis at the population level, which may be due to various mechanisms of transmission of infections and the required infectious dose of the pathogen. The absence of a negative effect of COVID-19 on mortality rates in HIV infection, viral hepatitis C and tuberculosis in the territories of the NWFD was noted. Special attention is paid to the clinical picture of the combined course of HIV infection, tuberculosis and COVID-19. The data are demonstrated, which allow us to conclude that the worst prognosis and risk of death are patients in the progressive stage of the disease, which is characterized by the presence of opportunistic infections, especially AIDS-indicator conditions, with disseminated tuberculosis and in the cirrhotic stage of viral hepatitis. The significance of severe manifestations of infectious pathology in cases of deterioration of the prognosis of COVID-19 is shown. Based on the experience of two years of the pandemic, the problems contributing to the syndrome of new coronavirus infection and other conditions, as well as the causes of high mortality from COVID-19, which include: limited resources for non-infectious areas of medical care; insufficient funding for planned and high-tech care; a decrease in the volume of primary diagnosis and detection of infectious and non-infectious pathology; delayed and limited research in areas; distraction of specialists from preventive and dispensary work outside of infectious pathology; shortage of medicines and consumables; social instability and deterioration of the well-being of the population, characteristic of pandemics. The role of a personalized approach to patients with concomitant somatic and infectious diseases as a preventive measure for the severe course and complications of COVID-19 is determined.

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COVID-19 pandemic and its impact on other infections in Northwest Russia

Belyakov

Боева

Simakina

et al. 2022

VIČ-infekc. immunosupr.

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The purpose statement is to assess the course of the COVID-19 pandemic and its impact on the epidemics of HIV infection, viral hepatitis C (HCV), tuberculosis, influenza, and acute respiratory infections in the North-Western Federal District (NWFD) of the Russian Federation during two years of spreading COVID-19 from the standpoint of the possible formation of syndemia or interference between pathogens.Materials and methods. Data collection on HIV infection and HCV was carried out by Pasteur Research Institute of Epidemiology and Microbiology at St. Petersburg Medical Information and Analytical Center using data from federal state statistical observation forms and our own research materials. The indicators of excess mortality from all causes for 2020 in the Northwestern Federal District (NWFD) and in the Russian Federation were analyzed according to the data of the Federal State Statistics Service (ROSSTAT). The results of epidemiological surveillance of HIV infection, viral hepatitis C (HCV), and tuberculosis in the Russian Federation and in the NWED in 2020 and 2021 in comparison with previous years are summarized. Studies of influenza and SARS were carried out by Smorodintsev Research Institute of Influenza and Gamaleya National Research Center for Epidemiology and Microbiology in cooperation with regional support bases. PCR detection of ARVI pathogens was carried out.Results and discussion. An analysis of epidemic indicators across the territories of the Northwestern Federal District of the Russian Federation made it possible to identify the following features: heterogeneity of the incidence of COVID-19 in the population in terms of time and intensity; the prevalence of morbidity in the metropolis (St. Petersburg) and industrial northern regions (the republics of Karelia and Komi). In a comparative aspect, the NWFD belongs to regions with high morbidity and mortality in the Russian Federation. St. Petersburg (378 deaths per 100,000 people in 2021) ranks second after Moscow. In turn, the Vologda, Murmansk, and Arkhangelsk regions, as well as the Komi Republic are among the top ten of the most affected subjects of the Russian Federation in the country. In terms of mortality, St. Petersburg was significantly ahead of all other subjects of the Russian Federation and the national average, which had several probable reasons. The first and second years of the pandemic did not reveal significant changes in epidemic rates of morbidity and mortality from other socially significant infections — HIV, HCV, and tuberculosis at the population level characteristic interference of viruses, where SARS-CoV-2 took the place of interfering, and influenza and SARS pretending or interfering pathogens. It took several months until the beginning of winter 2020 to crowd out seasonal respiratory infections by SARS-CoV-2. Then SARS-CoV-2 tightly captured the epidemic space, leaving no room for traditional respiratory infections, which accounted for less than 5% in early 2022.Conclusion. The COVID-19 epidemic had pronounced developmental features with higher morbidity and mortality in the metropolis and other industrial centers. The pandemic did not significantly affect the patterns of the epidemic course of HIV, HCV, and tuberculosis, which rejected the presence of a syndemic between these pathogens. Interference with respiratory infections — influenza and SARS — was revealed with a clear predominance of SARS-CoV-2.

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New coronoviral infection (COVID-19) combined with tuberculosis in patients at late stages of HIV infection with immunodeficiency

Cited by 6 publications

References 7 publications

Clinical and laboratory specific parameters of COVID-19 in patients with TB/HIV co-infection

Clinical and laboratory specific parameters of COVID-19 in patients with TB/HIV co-infection

Epidemiology and course of infectious diseases during the COVID-19 pandemic. Report 1. HIV infection, hepatitis c and tuberculosis

COVID-19 pandemic and its impact on other infections in Northwest Russia

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