New Coronaviral Infection: Features of Clinical Course, Capabilities of Diagnostics, Treatment and Prevention in Adults and Children

Старшинова, Анна; Кушнарева, Е. А.; Malkova, Anna; Довгалюк, И. Ф.; Кудлай, Д. А.

doi:10.15690/vsp.v19i2.2105

Cited by 37 publications

(12 citation statements)

References 62 publications

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“…From December 2019 to November 2020, the number of COVID-19 infected patients worldwide has been more than 50 million ( ) (accessed on 11 November 2020). The disease manifests as acute respiratory infection characterized by fever, cough and shortness of breath in the majority of patients; some develop neurological symptoms such as hypo-/anosmia and dysgeusia [ 1 , 2 ]. Unfortunately, around 20% of coronavirus-infected patients progress to the development of viral pneumonia, while some of them are likely to develop a very severe form of the disease.…”

Section: Introductionmentioning

confidence: 99%

Immunogenetic Predictors of Severe COVID-19

et al. 2021

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According to an analysis of published data, only 20% of patients with the new coronavirus infection develop severe life-threatening complications. Currently, there are no known biomarkers, the determination of which before the onset of the disease would allow assessing the likelihood of its severe course. The purpose of this literature review was to analyze possible genetic factors characterizing the immune response to the new coronavirus infection that could be associated with the expression of angiotension-converting enzyme 2 (ACE-2) and related proteins as predictors of severe Corona virus disease 2019 (COVID-19). We analyzed original articles published in Medline, PubMed and Scopus databases from December 2019 to November 2020. For searching articles, we used the following keywords: New coronavirus infection, Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), COVID-19, severe course, complications, thrombosis, cytokine storm, ACE-2, biomarkers. In total, 3714 publications were selected using the keywords, of which 8 were in congruence with all the criteria. The literature analysis of the association of immunogenic characteristics and the expression of ACE-2 and related proteins with the development of severe COVID-19 revealed following genetic factors: HLA-B*46:01 genotype, CXCR6 gene hypoexpression, CCR9 gene expression, TLR7, rs150892504 mutations in the ERAP2 gene, overexpression of wild-type ACE-2, TMPRSS2 and its different polymorphisms. Genes, associated with the severe course, are more common among men. According to the analysis data, it can be assumed that there are population differences. However, the diagnostic significance of the markers described must be confirmed with additional clinical studies.

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Section: Introductionmentioning

confidence: 99%

Immunogenetic Predictors of Severe COVID-19

et al. 2021

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“…According to many hallmark studies, in most cases of COVID-19 disease, children and adolescents have a mild progression (Baranov, 2020;Starshinova, 2020). What is more, there is a significant deterioration in health among pediatric patients against the background of chronic somatic and mental illnesses (Spasennikov, 2020;Starshinov, 2020;Sulaimanova & Alikbarova, 2020;Volkova & Shesternya, 2020).…”

Section: Introductionmentioning

confidence: 99%

Psychological Care For School-Age Patients With Covid-19 At Hospitals For Infectious Diseases

Sviridova¹

2021

European Proceedings of Social and Behavioural Sciences

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The Scientific Medical Research Center for Children's Health of the Ministry of Health of Russia was the first pediatric center to explore psychological state of 119 children (aged between 6.5 and 17) with COVID-19 during their hospital admission and outline the guidelines for psychological and pedagogical support. The authors analyzed medical and counseling documentation, conducted interviews, observations, screening tests. Based on physical and psychological factors (the main psychological difficulty), the patients can fall into three groups: 5 individuals (4 %) were very ill, with unstable signs of mental activity; 57 individuals (48 %) were mainly in a moderately grave state with severe feelings associated with the disease; 55 individuals (46 %) were in a satisfactory physical state, with mild and mainly situational difficulties in adapting to a hospital environment, and 2 individuals (2 %) were in a satisfactory physical state, in a relatively stable positive psychological state. Keeping track of physical and psychological severity and the main psychological difficulties allows hospital staff to provide children and adolescents with differentiated psychological care in specific "red zone" conditions.

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“…Появление COVID-19 в человеческой популяции несомненно изменило взгляд на инфекционные заболевания как в вопросе возможности взрывного характера развития эпидемиологического процесса, так и неопределенных и недостаточно изученных пока на сегодня последствий для здоровья детей и взрослых. Дети, по наблюдениям, болеют значительно реже, чем взрослые, в большей части переносят инфекцию в бессимптомной форме и играют большую роль в распространении инфекции [1][2][3]. По статистическим данным, в Российской Федерации среди заболевших на долю детского населения приходится до 10% [4].…”

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SARS-CoV-2-associated multisystem inflammatory syndrome in a child

Nagovitsyna¹

2021

Russian Journal of Woman and Child Health

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The COVID-19 infection occurs much less commonly in children than in adults, presumably due to the predominance of asymptomatic variants. Nevertheless, single deaths by the COVID-19 were reported in children worldwide. Some of these deaths result from multisystem inflammatory syndrome (MIS) that develops at late stages or after the COVID-19. MIS is characterized by acute onset, steady fever, skin and mucosal damage, and multiorgan failure. Unlike the classic variant of Kawasaki disease, MIS is associated with more frequent shocks and a more severe course. This paper addresses a case report of MIS with a favorable course and outcome in a 7-year-old boy. Practitioners should be aware that severe intoxication and inflammation with increased inflammatory markers emerging at late stages or after respiratory infections are potential manifestations of MIS. In these cases, tests for the COVID-19 should be timely performed; if found, pathogenic therapy is promptly initiated. Taking into account the insufficient knowledge of the pathogenesis and the knowledge of the consequences of MIS associated with SARS-CoV-2, long-term follow-up monitoring is required. KEYWORDS: coronavirus infection, COVID-19, SARS-СoV-2, multisystem inflammatory syndrome, Kawasaki-like syndrome, Kawasaki-like disease. FOR CITATION: Nagovitsyna N.M. SARS-CoV-2-associated multisystem inflammatory syndrome in a child. Russian Journal of Woman and Child Health. 2021;4(4):375–377 (in Russ.). DOI: 10.32364/2618-8430-2021-4-4-375-377.

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New Coronaviral Infection: Features of Clinical Course, Capabilities of Diagnostics, Treatment and Prevention in Adults and Children

Cited by 37 publications

References 62 publications

Immunogenetic Predictors of Severe COVID-19

Immunogenetic Predictors of Severe COVID-19

Psychological Care For School-Age Patients With Covid-19 At Hospitals For Infectious Diseases

SARS-CoV-2-associated multisystem inflammatory syndrome in a child

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