New copper(I) chloride complexes with heterocyclic thiones and triphenylphosphine as ligands. Crystal structures of [Cu(PPh3)2(bzimtH2)Cl·CH3COCH3 and [Cu(PPh3)2(nbzimtH2)Cl]

Skoulika, S.; Aubry, A.; Karagianidis, P.; Aslanidis, P.; Papastefanou, S.

doi:10.1016/s0020-1693(00)83016-9

Cited by 44 publications

(9 citation statements)

References 14 publications

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“…In the same report, CuBr(PPh 3 ) 3 was stirred in THF with Zr(pyridine-2-thione) 4 to produce crystals of the monomeric complex [CuBr(PPh 3 ) 2 (pyridine-thione-κS)] [4]. Setting the ratio of CuX to PPh 3 and thione at (1:2:1) produced complexes with CuX(PPh 3 ) 2 (thione) [5][6][7]. In another report, tri(p-tolyl)phosphine was employed with CuCl and 1,3-thiazolidine-2-thione (equimolar ratio) for producing dimeric complexes with bridging thiones [8].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structural Studies, and Anticancer Properties of [CuBr(PPh3)2(4,6-Dimethyl-2-Thiopyrimidine-κS]

et al. 2021

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CuBr(PPh3)2(4,6-dimethylpyrimidine-2-thione) (Cu-L) was synthesized by stirring CuBr(PPh3)3 and 4,6-dimethylpyrimidine-2-thione in dichloromethane. The crystal structure of Cu-L was obtained, and indicated that the complex adopts a distorted tetrahedral structure with several intramolecular hydrogen bonds. Moreover, a centrosymmetric dimer is formed by the intermolecular hydrogen bonding of the bromine acceptor created by symmetry operation 1−x, 1−y, 1−z to the methyl group (D3 = C42) of the pyrimidine–thione ligand. HSA-binding of Cu-L and its ligand were evaluated, revealing that Cu-L binds to HSA differently than its ligand. The HSA-bindings were modeled by molecular docking, which suggested that Cu-L binds to the II A domain while L binds between the I B and II A domains. Anticancer activities toward OVCAR-3 and HeLa cell lines were tested and indicated the significance of the copper center in enhancing the cytotoxic effect; negligible toxicities for L and Cu-L were observed towards a non-cancer cell line. The current study highlights the potential of copper(I)-phosphine complexes containing thione ligands as therapeutic agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Structural Studies, and Anticancer Properties of [CuBr(PPh3)2(4,6-Dimethyl-2-Thiopyrimidine-κS]

et al. 2021

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“…In view of this, Cu(I), Au(I), Ag(I), Cd(II), Hg(II), Pd(II) complexes with these ligands have been widely investigated [8][9][10][11]. These ligands exist in the N¼C-SH and N-C¼S forms exhibiting thiol-thione equilibrium [12,13].…”

Section: Introductionmentioning

confidence: 99%

Zinc halide complexes of imidazolidine-2-thione and its derivatives: X-ray structures, solid state, solution NMR and antimicrobial activity studies

Fettouhi

Wazeer

Isab

2007

Journal of Coordination Chemistry

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The preparation and characterization of zinc complexes of formula ZnL 2 X 2 (X ¼ Cl and Br), with L ¼ 1,3-diazinane-2-thione (Diaz), 1,3-diazipane-2-thione (Diap), imidazolidine-2-thione (Imt) and its methyl and n-propyl substituted derivatives, are described. The complexes dichlorobis(1-methylimidazolidine-2-thione-S)-zinc(II) (1) and dichlorobis(1-propylimidazolidine-2-thione-S)-zinc(II) (2) have been characterized by single-crystal X-ray methods. Both complexes adopt distorted tetrahedral geometry. Only intramolecular hydrogen bonding interactions are observed in 1 and 2. Solution and solid state 13 C NMR show a significant shift of the C¼S carbon resonance of the ligands, while other resonances are relatively unaffected, indicating that most likely the solid state structure is maintained in solution. Antimicrobial activity studies of the free ligands and their complexes show that ligands exhibit substantial antibacterial activities compared to the complexes.

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“…1). A distorted tetrahedral geometry is also found in the phosphine adducts of copper(I) halides (Aslanidis et al, 1993(Aslanidis et al, , 1998Aslanidis, Cox, Divanidis & Tsipis, 2002;Aslanidis, Cox, Karagiannidis et al, 2002;Cox et al, 2000;Karagiannidis et al, 1990;Lecomte et al, 1989;Skoulika et al, 1991). The CuÐI and CuÐS distances in (I) are similar to those observed in bis(triphenylphosphine)(pyrimidine-2-thione)copper(I) iodide (Aslanidis et al, 1993), and bis(triphenylphosphine)(benzimidazole-2-thione)copper(I) iodide and bis(triphenylphosphine)(benzothiazole-2-thione)copper(I) iodide (Aslanidis, Cox, Karagiannidis et al, 2002).…”

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confidence: 95%

Iodo(1-methyl-2-mercaptoimidazole-κS)bis(triphenylphosphine-κP)copper(I)

Luo

et al. 2004

Acta Cryst E

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Key indicatorsSingle-crystal X-ray study T = 296 K Mean '(C±C) = 0.007 A Ê R factor = 0.052 wR factor = 0.124 Data-to-parameter ratio = 20.4For details of how these key indicators were automatically derived from the article, see S)(C 18 H 15 P) 2 ] m727 metal-organic papers Figure 1 ORTEPII (Johnson, 1976) plot of (I), with displacement ellipsoids drawn at the 50% probability level. H atoms are drawn as spheres of arbitrary radii.

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New copper(I) chloride complexes with heterocyclic thiones and triphenylphosphine as ligands. Crystal structures of [Cu(PPh3)2(bzimtH2)Cl·CH3COCH3 and [Cu(PPh3)2(nbzimtH2)Cl]

Cited by 44 publications

References 14 publications

Synthesis, Structural Studies, and Anticancer Properties of [CuBr(PPh3)2(4,6-Dimethyl-2-Thiopyrimidine-κS]

Synthesis, Structural Studies, and Anticancer Properties of [CuBr(PPh3)2(4,6-Dimethyl-2-Thiopyrimidine-κS]

Zinc halide complexes of imidazolidine-2-thione and its derivatives: X-ray structures, solid state, solution NMR and antimicrobial activity studies

Iodo(1-methyl-2-mercaptoimidazole-κS)bis(triphenylphosphine-κP)copper(I)

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