New Constituents with Growth-Inhibitory Activity against the Co-115 Human Colon Carcinoma Cell Line and A New Antifungal Phloroglucinol Derivative from<i>Hypericum calycinum</i>

Décosterd, Laurent A.; Stœckli-Evans, Helen; Chapuis, Jean‐Charles; Sordat, Bernard; Hostettmann, Kurt

doi:10.1055/s-2006-962195

Cited by 2 publications

(1 citation statement)

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“…Each of these classes can be then further characterised by chemical substitutions, resulting in numerous variants, and for an extensive review, see Singh and Bharate [ 19 ]. Phluoroglucinols, from their simplest form to the more complex structures, have demonstrated an extreme variety of bioactive properties including antimicrobial properties such as antiviral, antibacterial and antifungal properties [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]; antidepressant effects [ 27 , 28 ]; human keratinocyte proliferation ability [ 29 ]; antioxidant and cytotoxic activities [ 30 , 31 ]; and anticancer [ 32 , 33 ] and neuroprotective effects [ 34 ]. This extreme variation in structures and related functions suggest a pleomorphic functionality of the basic phloroglucinol which is supported by a near ubiquitous presence in the plant kingdom.…”

Section: Introductionmentioning

confidence: 99%

Phloroglucinol Mediated Plant Regeneration of Ornithogalum dubium as the Sole “Hormone-Like Supplement” in Plant Tissue Culture Long-Term Experiments

Petti

2020

Plants

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Tissue culture is an essential requirement in plant science to preserve genetic resources and to expand naturally occurring germplasm. A variety of naturally occurring and synthetic hormones are available to induce the processes of dedifferentiation and redifferentiation. Not all plant material is susceptible to tissue culture, and often complex media and hormone requirements are needed to achieve successful plant propagations. The availability of new hormones or chemicals acting as hormones are critical to the expansion of tissue culture potentials. Phloroglucinol has been shown to have certain hormone-like properties in a variety of studies. Ornithogalum dubium, an important geophyte species, was used to characterise the potential of phloroglucinol as the sole plant-like hormone in a tissue culture experiment. Tissue culture, plant regeneration, total phenolic and genetic variability were established by applying a variety of methods throughout long-term experiments. Phloroglucinol did induce callus formation and plant regeneration when used as the sole supplement in the media at a rate of 37%, thus demonstrating auxin/cytokines-like properties. Callus formation was of 3 types, friable and cellular, hard and compact, and a mixture of the two. The important finding was that direct somatogenesis did occur albeit more frequently on younger tissue, whereby rates of induction were up to 52%. It is concluded that phloroglucinol acts as a “hormone-like” molecule and can trigger direct embryogenesis without callus formation.

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