New concepts on the interference on alkylating antitumor agents with the regulation of cell division

Grunicke, H.; Gantner, G.; Holzweber, Friedrich; Ihlenfeldt, M.; Puschendorf, Bernd

doi:10.1016/0065-2571(79)90018-9

Cited by 13 publications

(1 citation statement)

References 22 publications

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“…The formation of DNA-interstrand cross-links seems to play an important role for the cell-killing effect (Kohn et al 1966;Lawley & Brookes 1967;Parsons 1984;Roberts 1975;Ross et al 1978). Moreover, other chemical events such as DNA-intrastrand (Walker 1971), DNAprotein cross-links (Ewig & Kohn 1977;Klatt et al 1969), reaction with cyclic 3',5'-nucleotide phosphodiesterase (Tisdale & Phillips 1975) and reaction with the plasma membrane (Baxter et al 1982;Grunicke et al 1979) have been suggested to contribute to the cytotoxic activity.…”

mentioning

confidence: 99%

Concentration and Time-dependent Inter-relationships for Cytotoxicities of Nitrogen Mustard Drugs against Lymphoblasts In-vitro

Ehrsson¹,

Wallin²,

Ringborg³

1988

Journal of Pharmacy and Pharmacology

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Peripheral lymphoblasts were exposed either to different initial concentrations of the alkylating agents (melphalan, chlorambucil or phenylacetic acid mustard) using a fixed incubation time or a constant [3H]methylthymidine incorporation into the trichloracetic acid-insoluble fraction of the cells. The concentration-time relationships were evaluated by calculating the amount of drug which had chemically reacted in the incubation system. Melphalan showed lower cytotoxicity at short exposure times and high drug concentrations, while chlorambucil exhibited higher cytotoxicity at longer exposure times. In the latter case the effect could be accounted for by the cytotoxic activity of monohydroxy chlorambucil which was formed in the incubation system.

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