New Concepts of Ureterovesical Innervation

Schulman, Claude; Duarte-Escalante, O.; Boyarsky, Saul; Grégoir, W

doi:10.1016/s0022-5347(17)60430-0

Cited by 16 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autonomic nerves, which supply the smooth muscle of the VUJ, are also believed to play an important role in the control of normal function [ 4, 5]. Neurohistochemical methods have shown a dual autonomic innervation formed by both noradrenergic and cholinergic nerves [ 6–9]. More recently, many of these autonomic nerves have been shown to contain a variety of neuropeptides which may act as neuromodulators or neurotransmitters [ 10, 11].…”

Section: Introductionmentioning

confidence: 99%

The structure and autonomic innervation of the vesico‐ureteric junction in cases of primary ureteric reflux

Dixon

Jen

Yeung³

et al. 1998

British Journal of Urology

View full text Add to dashboard Cite

Objective To determine the histological structure and autonomic innervation of the vesico‐ureteric junction (VUJ) in cases of primary ureteric reflux, to compare the results with those reported previously for non‐refluxing VUJs and thus determine possible structural anomalies which could be responsible for vesico‐ureteric reflux (VUR). Materials and methods Nineteen specimens of VUJs with reflux were obtained from four males and 10 females undergoing ureteric reimplantation. Serial frozen sections were cut and stained either with Masson’s trichrome or immunostained for protein gene product (PGP 9.5), a general nerve marker, dopamine beta hydroxylase (DβH), a marker for noradrenergic nerves, or neuropeptide Y (NPY). Results Longitudinally orientated muscle bundles of narrow diameter accompanied the ureter to its termination at the ureteric orifice, where they merged with those of the superficial trigone. In some specimens, an additional muscle component was identified, situated on the outer aspect of the ureteric muscle coat, consisting of an incomplete layer of distinctive muscle whose constituent cells formed an interlacing meshwork. Occasionally, specimens included detrusor muscle which consisted of relatively large diameter compact bundles separated from the ureter by a connective tissue sheath. DβH‐ and NPY‐immunoreactive (‐IR) nerves were numerous among the ureteric muscle bundles. Many NPY‐IR nerves occurred within the detrusor muscle while DβH‐IR nerves were mainly perivascular. When present, the outer muscle component was richly innervated by both DβH‐ and NPY‐IR nerves. PGP immunoreactivity varied among regions in the same section, PGP‐IR nerves frequently being less numerous than those containing DβH or NPY. Conclusion These results indicate that the morphology of the VUJ in cases of VUR is indistinguishable from the normal VUJ described previously. Furthermore, the density and distribution of DβH‐ and NPY‐IR nerves is identical to that in controls. However, the antigenicity of PGP in the reflux specimens appears to be masked in some regions by an unknown factor.

show abstract

Section: Introductionmentioning

confidence: 99%

The structure and autonomic innervation of the vesico‐ureteric junction in cases of primary ureteric reflux

Dixon

Jen

Yeung³

et al. 1998

British Journal of Urology

View full text Add to dashboard Cite

show abstract

“…Morphological studies have demonstrated that the density of the nerve supply increases progressively from the top end of the ureter towards the bladder, the pelvic segment being more richly innervated than the lumbar, suggesting a higher nervous control of the intravesical ureter (Hannappel & Golenhofen, 1974). In addition, several studies have shown by means of histochemical techniques, that there is a rich network of adrenergic nerve fibres at the distal ureter and ureterovesical junction (El-Badawi & Schenk, 1971; Schulman et al, 1973;Schulman, 1985;Prieto et al, 1989; and numerous ganglion cells that constitute the ureterovesical ganglion complex which could play an important role in the coordination of the ureter and bladder activity at the ureterovesical junction (Schulman, 1985). I Author for correspondence.…”

Section: Introductionmentioning

confidence: 99%

Noradrenaline modulates smooth muscle activity of the isolated intravesical ureter of the pig through different types of adrenoceptors

Hernández

Prieto

Simonsen

et al. 1992

British J Pharmacology

View full text Add to dashboard Cite

We have studied the effects of α‐ and β‐adrenoceptor agonists and antagonists on both phasic peristaltic activity and basal tone of the isolated intravesical ureter of the pig by means of isometric techniques in vitro. Spontaneous phasic activity was exhibited by 21% of pig intravesical ureter preparations manifested as rhythmic contractions with average frequency and amplitude of 2.54 ± 0.18 min−1 and 1.48 ± 0.16 g (n = 31), respectively. Adrenaline, noradrenaline and phenylephrine induced concentration‐dependent increases in both phasic activity and basal tone of ureteral preparations, all three agonists being more potent in modifying ureteral phasic activity than baseline tone. B‐HT 920, B‐HT 933 and clonidine had no significant effect. Phentolamine (10−9 − 10−7 m) and prazosin (3 × 10−11 − 3 × 10−8 m) significantly inhibited increases in both frequency of phasic activity and baseline tone induced by a submaximal dose of noradrenaline. Rauwolscine (10−9 − 10−7 m) affected only the tone evoked by noradrenaline and higher concentrations of this antagonist were needed to block phasic activity. Pretreatment of ureteral strips with the β‐adrenoceptor antagonist, propranolol (10−6 m), significantly increased the maximum contraction evoked by noradrenaline. After incubation with phentolamine (10−6 m), noradrenaline (10−7 − 10−6 m) decreased phasic activity induced by prostaglandin F2α (10−5 m). Isoprenaline and salbutamol also abolished PGF2α‐induced phasic activity. Pafenolol (10−6 m) and butoxamine (10−6 m) blocked the inhibitory effect of noradrenaline, isoprenaline, and salbutamol on PGF2α‐induced phasic activity. These results suggest that noradrenaline may modulate both phasic peristaltic activity and basal tone of pig intravesical ureter through both α‐ and β‐adrenoceptors.

show abstract

“…Of interest, three of the aforementioned patients also had aganglionosis of the ureters [Bamforth et al, 1989; Davis and Samarakkody, 2002]. In contrast to normal colon and esophagus, ganglion cells are not present in the walls of the normal ureter, but are found in the connective tissue sheath (Waldeyer's) surrounding the distal ureter [Schulman et al, 1973]. Schulman [1974] noted that those ganglia are part of an ureterovesical ganglionic complex that can integrate the function of the terminal ureter and the bladder during micturition.…”

Section: Discussionmentioning

confidence: 99%

Fryns syndrome with Hirschsprung disease: Support for possible neural crest involvement

Alkuraya

Lin

Irons

et al. 2004

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Fryns syndrome is an autosomal recessive multiple congenital anomaly/mental retardation syndrome characterized by coarse face, distal limb hypoplasia, and diaphragmatic anomalies. We describe a newborn girl with Fryns syndrome and Hirschsprung disease, an association that has been reported in five previous cases. These patients support the hypothesis that the neural crest plays a role in the pathogenesis of Fryns syndrome. Clinically asymptomatic or subtle anomalies that are in the spectrum of neural crest maldevelopment should be sought in all patients with Fryns syndrome including stillbirths, neonatal deaths, as well as long-term survivors. We suspect that the clinical observation about Hirschsprung disease and Fryns syndrome may provide insight into its molecular mechanisms and candidate genes.

show abstract

New Concepts of Ureterovesical Innervation

Cited by 16 publications

References 8 publications

The structure and autonomic innervation of the vesico‐ureteric junction in cases of primary ureteric reflux

The structure and autonomic innervation of the vesico‐ureteric junction in cases of primary ureteric reflux

Noradrenaline modulates smooth muscle activity of the isolated intravesical ureter of the pig through different types of adrenoceptors

Fryns syndrome with Hirschsprung disease: Support for possible neural crest involvement

Contact Info

Product

Resources

About