New Concepts of the Interplay Between the Gut Microbiota and the Enteric Nervous System in the Control of Motility

Vicentini, Fernando; Fahlman, Tanner; Raptis, Stephanie G; Wallace, Laurie E.; Hirota, Simon A.; Sharkey, Keith A.

doi:10.1007/978-3-031-05843-1_6

Cited by 3 publications

(3 citation statements)

References 99 publications

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“…10 Mechanistically, studies in obese animal models link dysbiosis and low-grade inflammation to altered nerve function and dysmotility. 9,11…”

Section: Intestinal Barrier Functionmentioning

confidence: 99%

“…8 The regulation of gut contraction is an intricate process, involving coordination of enteroendocrine cells, autonomic and enteric nervous system, and pacemaker cell signaling. 9 Together these effectors influence mixing and propulsion of gut contents, the sensation of satiety, digestive secretions, induction of nutrient and fluid transport, local blood flow and immune responses, disturbance of which may contribute to chronic disease. 9 For example, in humans obesity is associated with accelerated colonic transit time and chronic diarrhea.…”

Section: Intestinal Barrier Functionmentioning

confidence: 99%

“…9 Together these effectors influence mixing and propulsion of gut contents, the sensation of satiety, digestive secretions, induction of nutrient and fluid transport, local blood flow and immune responses, disturbance of which may contribute to chronic disease. 9 For example, in humans obesity is associated with accelerated colonic transit time and chronic diarrhea. 10 Mechanistically, studies in obese animal models link dysbiosis and low-grade inflammation to altered nerve function and dysmotility.…”

Section: Intestinal Barrier Functionmentioning

confidence: 99%

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Antihypertensives and Antibiotics: Impact on Intestinal Dysfunction and Hypertension

et al. 2023

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Gut dysfunction has emerged as a contributor to hypertension, the leading risk factor for disease globally, including stroke, heart failure, and kidney disease. This is underpinned by breakdown of the homeostatic relationship connecting intestinal epithelial function, the microbiota and immune responses. Antihypertensive medications have been shown to reverse intestinal dysfunction and gut dysbiosis. However, the mechanisms underlying this restoration of gut structure and function remain largely unknown. In this review, we examine current knowledge supporting a role for impaired intestinal epithelial permeability in hypertension, focusing on electrolyte movement, the renin-angiotensin-aldosterone system, and the restorative effects of orally administered antihypertensive medications and antibiotics. Further work is required to determine if the association between intestinal dysfunction and hypertension is causal. This is a rapidly evolving field, with intestinal dysfunction and dysbiosis representing an area that may be exploited to improve treatment of hypertension and cardiovascular disease.

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“…10 Mechanistically, studies in obese animal models link dysbiosis and low-grade inflammation to altered nerve function and dysmotility. 9,11…”

Section: Intestinal Barrier Functionmentioning

confidence: 99%

Section: Intestinal Barrier Functionmentioning

confidence: 99%

Section: Intestinal Barrier Functionmentioning

confidence: 99%

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Antihypertensives and Antibiotics: Impact on Intestinal Dysfunction and Hypertension

et al. 2023

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Mini-review: Interaction between intestinal microbes and enteric glia in health and disease

Seguella

Palenca

Franzin

et al. 2023

Neuroscience Letters

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Electroacupuncture Ameliorates Gastrointestinal Motility in Rats with Functional Dyspepsia Via PLC/IP3 Signaling

Yang

Chang

Jin

et al. 2023

Preprint

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Gastrointestinal motility disorders are one of the main pathogenic factors responsible for functional dyspepsia (FD). Platelet-derived growth factor receptor-α-positive (PDGFRα+) cells participate in regulating gastrointestinal motility; however, the underlying mechanisms remain unclear. Herein, we aimed to assess the therapeutic effects of electroacupuncture (EA) and determine whether EA modulates the phospholipase C (PLC)-inositol-1,4,5-trisphosphate (PLC-IP3) pathway in PDGFRα+ cells to improve gastrointestinal motility disorders in FD. Accordingly, FD rats stimulated by tail-clamping were treated with EA (with or without PLC inhibitor U73122). We observed that the PLC-IP3 pathway was modulated in PDGFRα+ cells, which improved gastrointestinal motility in FD model rats. Based on western blotting and immunofluorescence assay results, EA increased the expression of PDGFRα+ cells and promoted the expression of PLC, P-PLC, and IP3 in the gastric sinuses of FD rats. U73122-mediated inhibition of PLC expression treatment considerably reduced the frequency of gastrointestinal motility. However, there was no significant difference between the effects of antagonist and antagonist + EA treatments; EA treatment was superior to antagonist and antagonist + EA treatment alone. Overall, these results suggest that EA could ameliorate gastrointestinal motility disorders in FD rats by activating the PLC-IP3 pathway in PDGFRα+ cells.

show abstract

New Concepts of the Interplay Between the Gut Microbiota and the Enteric Nervous System in the Control of Motility

Cited by 3 publications

References 99 publications

Antihypertensives and Antibiotics: Impact on Intestinal Dysfunction and Hypertension

Antihypertensives and Antibiotics: Impact on Intestinal Dysfunction and Hypertension

Mini-review: Interaction between intestinal microbes and enteric glia in health and disease

Electroacupuncture Ameliorates Gastrointestinal Motility in Rats with Functional Dyspepsia Via PLC/IP3 Signaling

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