1991
DOI: 10.1159/000235333
|View full text |Cite
|
Sign up to set email alerts
|

New Concepts of IgE Regulation

Abstract: B cell switch to IgE expression is mediated by IL-4 and is regarded as a T helper cell-related phenomenon. In this overview we describe that IgE switch can also be induced by mast cell/basophil like cells (from splenic non-B, non-T cells), activated by IgE receptor cross-linking and/or IL-3 which results in IL-4 production by these cells. Furthermore, activated mast cells produce their own growth factors, IL-3 and GM-CSF. Thus, activation of mast cells can provoke an ongoing local allergic reaction as long as … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

0
16
0

Year Published

1993
1993
2003
2003

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 24 publications
(16 citation statements)
references
References 21 publications
(24 reference statements)
0
16
0
Order By: Relevance
“…Our results indicate that chronic infection with H. felis inhibits the establishment of oral tolerance by preventing IgE suppression, normally in- duced after OVA feeding. As IgG1 and IgE antibody responses are regulated by Th2 populations (21), it is likely that a down-regulation of Th2-dependent responses occurred after OVA feeding. The mechanisms by which the development of oral tolerance is inhibited in the presence of H. felis infection may involve the increase in antigenic absorption across the epithelium (28,29) and the presence of the bacterial adjuvants.…”
Section: Discussionmentioning
confidence: 99%
“…Our results indicate that chronic infection with H. felis inhibits the establishment of oral tolerance by preventing IgE suppression, normally in- duced after OVA feeding. As IgG1 and IgE antibody responses are regulated by Th2 populations (21), it is likely that a down-regulation of Th2-dependent responses occurred after OVA feeding. The mechanisms by which the development of oral tolerance is inhibited in the presence of H. felis infection may involve the increase in antigenic absorption across the epithelium (28,29) and the presence of the bacterial adjuvants.…”
Section: Discussionmentioning
confidence: 99%
“…Immunoglobulin E (IgE) production is low in normal conditions, but increases during allergic responses. Findings obtained in vitro and in vivo using specific antibodies indicate that interleukin‐4 (IL‐4), mainly derived from T‐helper type 2 (Th2) cells, and CD40 ligand, expressed on activated T lymphocytes, are two essential signals which are required for IgE‐isotype switch and IgE production by B lymphocytes 1 –4 . IL‐4 (−/−) mice can be used to study the biological significance of this cytokine in vivo , especially its role in the regulation of IgE production.…”
Section: Introductionmentioning
confidence: 99%
“…Key words: Mast cells; precursors; rats; IgE; receptors, IgE; gold colloid; microscopy; immunoelectron. Weinstein 1986; Galli 1990) or in the regulation of IgE synthesis (Coffman & Carry 1986; Finkelmann et al 1988; Ishizaka 1989; Pine et al 1988;Heusser et al 1991). In our previous studies in which cytofluorometry was used, it was found that there were considerable numbers of IgE molecules on the mast cells of barriermaintained rats.…”
mentioning
confidence: 99%