New concepts of <i>Mycoplasma pneumoniae</i> infections in children

Waites, Ken B.

doi:10.1002/ppul.10346

Cited by 145 publications

(147 citation statements)

References 111 publications

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“…3 M. pneumoniae is a common cause of CAP and other community-acquired lower respiratory tract infections (CA-LRTIs), particularly in school-age children and adolescents, but there are large gaps in our understanding of this disease. 3,4 Prevalence estimates vary from 10% to 40% in pediatric CA-LRTI, [5][6][7][8][9] and few studies address treatment recommendations. 4,10 Additionally, the IDSA guidelines target the use of macrolides in CA-LRTI as an area needing additional research.…”

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confidence: 99%

Treatment of Mycoplasma Pneumonia: A Systematic Review

et al. 2014

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BACKGROUND AND OBJECTIVE: Children with community-acquired lower respiratory tract infection (CA-LRTI) commonly receive antibiotics for Mycoplasma pneumoniae. The objective was to evaluate the effect of treating M. pneumoniae in children with CA-LRTI.METHODS: PubMed, Cochrane Central Register of Controlled Trials, and bibliography review. A search was conducted by using Medical Subject Headings terms related to CA-LRTI and M. pneumoniae and was not restricted by language. Eligible studies included randomized controlled trials (RCTs) and observational studies of children #17 years old with confirmed M. pneumoniae and a diagnosis of CA-LRTI; each must have also compared treatment regimens with and without spectrum of activity against M. pneumoniae. Data extraction and quality assessment were completed independently by multiple reviewers before arriving at a consensus. Data were pooled using a random effects model. RESULTS:Sixteen articles detailing 17 studies were included. The most commonly selected primary outcome was symptomatic improvement. Nine studies examined M. pneumoniae treatment in CA-LRTI secondary to M. pneumoniae, and 5 RCTs met criteria for meta-analysis. The suggested pooled risk difference of 0.12 (95% confidence interval, 20.04 to 0.20) favoring treatment was not significantly different and demonstrated significant heterogeneity. Limitations included substantial bias and subjective outcomes within the individual studies, difficulty interpreting testing modalities, and the inability to correct for mixed infections or timing of intervention. CONCLUSIONS:We identified insufficient evidence to support or refute treatment of M. pneumoniae in CA-LRTI. These data highlight the need for well-designed, prospective RCTs assessing the effect of treating M. pneumoniae in CA-LRTI.

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confidence: 99%

Treatment of Mycoplasma Pneumonia: A Systematic Review

et al. 2014

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“…17 Disease course was longest in the positive serology group (120 days), compared to the 45 days of the negative serology group. Dry cough was most frequent in the positive serology group.…”

Section: Discussionmentioning

confidence: 99%

“…According to the literature, when the MP infection is located in the trachea, bronchi and bronchioles, the result is constant, uncontrollable, nonproductive coughing, awakening the patient in the middle of the night and preventing them from going back to sleep. 17 We should stress that the absence of this symptom does not rule out MP infection, and that absence of coughing was greater for the positive serology group (22.11%) than for negative cases (13.68%).…”

Section: Discussionmentioning

confidence: 99%

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Características clínico-radiológicas e hematológicas das pneumonias causadas pelo Mycoplasma pneumoniae

Vervloet¹,

Camargos²,

Soares³

et al. 2010

J. Pediatr. (Rio J.)

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Objective: To describe the clinical, hematological and radiographic characteristics of children hospitalized for Mycoplasma pneumoniae pneumonia. Method:The study population consisted of 190 children between 3 months and 16 years old, hospitalized for radiographically confirmed pneumonia. Patients were divided into two groups, to wit: 95 children with Mycoplasma pneumoniae pneumonia, as diagnosed using the enzyme-linked immunosorbent assay (ELISA) method; and 95 children with pneumonia caused by other etiologic agents. Using a validated scoring system, the clinical, hematological and radiographic findings of both groups were compared to differentiate Mycoplasma pneumoniae pneumonia (group 1) from pneumonia caused by other etiologic agents (group 2), itself divided into two groups, bacterial (n = 75) and viral (n = 20).Results: Mycoplasma pneumoniae pneumonia was found most often in girls (p < 0.01), older children (p < 0.01), and patients with dry cough (p < 0.01) and extrapulmonary manifestations (p < 0.01). The clinical, hematological and radiographic variables of Mycoplasma pneumoniae pneumonia (mean score = 6.95) scored between those found in bacterial (mean score = 8.27) and viral pneumonia (mean score = 0.90). Conclusion:Results suggest that the scoring system can contribute to the presumptive diagnosis of Mycoplasma pneumoniae pneumonia and help differentiate pneumonic status caused by other etiologic agents.J Pediatr (Rio J). 2010;86(6):480-487: Mycoplasma, Mycoplasma pneumoniae, pneumonia, radiography, children. No conflicts of interest declared concerning the publication of this article. Organization (WHO). 9 MP pneumonia was defined by the Mycoplasma pneumoniae pneumonia -Vervloet LA et al. Original article

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“…M. pneumoniae infection manifests as pharyngitis, bronchitis and atypical pneumonia in children and adolescents (1).…”

Section: Introductionmentioning

confidence: 99%

A Case of Acute Myopericarditis Associated with Mycoplasma pneumoniae Infection in a Korean Adult

et al. 2009

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We report on a 45-year-old man with a confirmed diagnosis of acute myopericarditis associated with Mycoplasma pneumoniae. He visited our emergency department due to high fever (39℃) via a primary clinic. We made a diagnosis of myopericarditis based on symptoms, cardiac enzymes, electrocardiography, and transthoracic echocardiography. Serology (particle agglutination) testing for M. pneumoniae IgG antibody was also performed. The IgG antibody titer was 1:80 on the second day of admission, and increased to 1:2,560 by the 12th day of admission. Therefore, we confirmed the diagnosis of acute myopericarditis associated with M. pneumoniae and subsequently treated him with azithromycin. The symptoms and laboratory findings improved, and he recovered uneventfully.

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New concepts of Mycoplasma pneumoniae infections in children

Cited by 145 publications

References 111 publications

Treatment of Mycoplasma Pneumonia: A Systematic Review

Treatment of Mycoplasma Pneumonia: A Systematic Review

Características clínico-radiológicas e hematológicas das pneumonias causadas pelo Mycoplasma pneumoniae

A Case of Acute Myopericarditis Associated with Mycoplasma pneumoniae Infection in a Korean Adult

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