New concepts in the pathogenesis of asthma

Larsen, Gary L.

doi:10.1016/0090-1229(89)90076-7

Cited by 9 publications

(6 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this re gard, altered adrenal responses, as reflected by serum cor tisol concentrations, appear to play a role, protective or otherwise in the development of late asthmatic responses. The development of symptomatic late responses and asso ciated increased bronchial responsiveness arc relevant to day to day asthma [8], It has been suggested that the threshold of bronchoconstriction in individuals with bron chial hyperreactivity is effected by endogenous cortisol levels [9,10].…”

Section: Discussionmentioning

confidence: 99%

Bronchial Asthma with Addison’s Disease

Saraçlar

Türktaş²,

Adalioğlu³

et al. 1993

Respiration

View full text Add to dashboard Cite

A 14-year-old boy with bronchial asthma who was subsequently diagnosed to have coexistent Addison’s disease is presented. Both diseases responded to continuous replacement steroid therapy. We suggest that worsening of bronchial asthma symptoms in this patient may be due to the hypocortisolemia produced by the coexistent Addison’s disease. Patients with Addison’s disease with clinical evidence of bronchial asthma have rarely been reported [1, 2]. A 14-year-old boy in whom symptoms of bronchial asthma obscured the otherwise obvious diagnosis of adrenocortical insufficiency is presented.

show abstract

Section: Discussionmentioning

confidence: 99%

Bronchial Asthma with Addison’s Disease

Saraçlar

Türktaş²,

Adalioğlu³

et al. 1993

Respiration

View full text Add to dashboard Cite

show abstract

“…are thought to be especially important in mainluining airway hyperresponsiveness. Many other studies also report that airway inflammation is important in maintaining airway hyperresponsiveness and chronic asthmatic symptoms [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Pathological changes according to the severity of asthma

Cho

Seo

Choi

et al. 1996

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…1,2) Of these three responses, IAR is sudden and strong and can be life-threatening in asthmatic patients.…”

mentioning

confidence: 99%

Two Pharmacological Phases in Antigen-Induced Immediate Airway Response in Rats

Miyagawa

Iwasaki

Kato

et al. 2008

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The pharmacological profiles of antigen-induced immediate airway response (IAR) in rats are not fully understood. In this study, we established an ovalbumin (OVA)-induced IAR model using noninvasive measurement in rats, and evaluated the effects of commonly used and effective antiasthmatic drugs, i.e. ketotifen (antihistamine), pranlukast (anti-leukotriene C 4 /D 4 /E 4 (LT)), seratrodast (anti-thromboxane A 2 (TXA 2 )), salbutamol (b b2-agonist), and prednisolone (steroid). The rat IAR model exhibited an optimal rapid airway response, and salbutamol inhalation completely suppressed the IAR. Ketotifen inhibited only the quick phase (QP; the reaction from 3 to 6 min after challenge), while pranlukast and seratrodast suppressed only the early phase (EP; the reaction from 6 to 30 min after challenge). Prednisolone inhibited both QP and EP. Further, continuous administration of compound 48/80, which depletes connective tissue mast cells (CTMC), partially inhibited QP but not EP. In conclusion, these findings suggest that the pharmacological profiles of noninvasive rat IAR are similar to those of asthmatic patients, and that rat IAR exhibits additional, immunological diverse characteristics, i.e. QP caused by the exocytosis of mediators in CTMCs and EP mediated by LT and TXA 2 , which are produced by mucosal mast cells (MMCs) and possibly by other types of cells. This is the first report about the comprehensive pharmacological profiles of rodent IAR model, and these analyses of rat IAR model may help expand our understanding of the diverse mechanisms underlying human asthmatic diseases.

show abstract

New concepts in the pathogenesis of asthma

Cited by 9 publications

References 45 publications

Bronchial Asthma with Addison’s Disease

Bronchial Asthma with Addison’s Disease

Pathological changes according to the severity of asthma

Two Pharmacological Phases in Antigen-Induced Immediate Airway Response in Rats

Contact Info

Product

Resources

About