New concepts in the pathogenesis of atopic dermatitis

Relación entre dermatitis atópica y alergia alimentaria

“…Las lesiones crónicas contienen eosinófilos, células que contribuyen a la inflamación y a la injuria del tejido, a través de la producción de radicales de oxígeno, citoquinas proinflamatorias y liberación de proteínas tóxicas de los gránulos. La piel de pacientes con DA sin lesiones aparentes también presenta alteraciones histológicas 12 .…”

“…Aproximadamente un 80% de los pacientes con DA presentan un aumento de los niveles séricos de IgE. Sin embargo, debido a que este marcador no está presente en todos los casos de DA, esta enfermedad ha sido dividida en 2 subtipos [11][12][13][16][17][18] . Figura 2.…”

Barrier Repair Therapy in Atopic Eczema: New Evidences in Improving Skin Functions with Topical Emolliency and Hydration Strategies

“…Ceramide, filaggrin and Anti-Microbial-Peptides (AMP) defects are the three main mechanisms which characterize the skin barrier defect of AE [41]. Therefore an "ideal" emollient-moisturizing product should restore the lipid mantle, improve skin hydration and if possible to re-establish a normal AMP production.…”

Suppression of 2,4-dinitrochlorobenzene-induced atopic dermatitis by extract of Bacillus Calmette-Guerin

“…AD is a biphasic inflammatory skin disease that is provoked by an imbalance between T-helper (Th) 1 and Th2 immune responses. In particular, AD has been associated with the Th2 phenotype in which interleukin (IL)-4, IL-5, and IL-13 secretion and Th2-type cytokine-mediated IgE production are dominant (1). In addition, the accumulation of large numbers of eosinophils, mast cells and dendritic cells (DCs) has been observed in the epidermis and the dermis of patients with AD (2).…”