New concept on an integrated interior magnetic resonance imaging and medical linear accelerator system for radiation therapy

Jia, Xun; Tian, Zhen; Xi, Yan; Jiang, Steve B; Wang, Ge

doi:10.1117/1.jmi.4.1.015004

Cited by 5 publications

(7 citation statements)

References 58 publications

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“…MRI yields superb soft-tissue visualisation and provides several imaging modalities for identifying movement, function and physiology without delivering any additional dose to the patient. Various integrated MRI-guided radiation therapy systems have been developed, such as the hybrid MRI–LINAC [ 115 , 116 ], which is still a prototype, and the Viewray system (MRIdian System, ViewRay, Inc., Cleveland Oakwood Village, OH, USA) [ 117 ], which has been in clinical use for the last couple of years.…”

Section: Technological Advancesmentioning

confidence: 99%

“…Several techniques have been proposed to reduce the effects of respiratory motion, from simple motion-encompassing, respiratory gating, either in free-breathing or in breath hold, to dynamic tumour tracking (DTT) [ 116 , 127 ]. With the motion-encompassing technique, the mean position and the range of tumour motion are estimated from fluoroscopy or four-dimensional CT (4D-CT) data to define the internal target volume (ITV).…”

Section: Technological Advancesmentioning

confidence: 99%

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Recent advances in radiation oncology

Garibaldi

Jereczek‐Fossa

Marvaso

et al. 2017

ecancer

100

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Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing. We will analyse all the steps involved in the treatment: imaging, delineation of the tumour and organs at risk, treatment planning and finally image-guidance for accurate tumour localisation before and during treatment delivery. Particular attention will be given to the crucial role that imaging plays throughout the entire process. In the case of adaptive RT, the precise identification of target volumes as well as the monitoring of tumour response/modification during the course of treatment is mainly based on multimodality imaging that integrates morphological, functional and metabolic information. Moreover, real-time imaging of the tumour is essential in breathing adaptive techniques to compensate for tumour motion due to respiration.Brief reference will be made to the recent spread of particle beam therapy, in particular to the use of protons, but also to the yet limited experience of using heavy particles such as carbon ions.Finally, we will analyse the latest biological advances in tumour targeting. Indeed, the effectiveness of RT has been improved not only by technological developments but also through the integration of radiobiological knowledge to produce more efficient and personalised treatment strategies.

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Section: Technological Advancesmentioning

confidence: 99%

Section: Technological Advancesmentioning

confidence: 99%

Recent advances in radiation oncology

Garibaldi

Jereczek‐Fossa

Marvaso

et al. 2017

ecancer

100

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“…Integrated magnetic resonance imaging (MRI) and radiotherapy systems are clinically established in image‐guided radiotherapy (IGRT) . Furthermore, there are several systems with unique configurations such as inline orientation with biplanar magnet and inline/perpendicular orientation with open magnet under development . The integrated MRI and radiotherapy systems can provide real‐time tumor tracking, inclusive of changes in tumor position and shape, since MRI produces superior soft tissue contrast of patient anatomy without ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4] Furthermore, there are several systems with unique configurations such as inline orientation with biplanar magnet and inline/perpendicular orientation with open magnet under development. [5][6][7][8] The integrated MRI and radiotherapy systems can provide real-time tumor tracking, inclusive of changes in tumor position and shape, 2,9,10 since MRI produces superior soft tissue contrast of patient anatomy without ionizing radiation. MRI-guided radiotherapy (MRgRT) gives excellent local control with little toxicity.…”

Section: Introductionmentioning

confidence: 99%

Technical Note: Real‐time 3D MRI in the presence of motion for MRI‐guided radiotherapy: 3D Dynamic keyhole imaging with super‐resolution

et al. 2019

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Purpose The purpose of this study was to present real‐time three‐dimensional (3D) magnetic resonance imaging (MRI) in the presence of motion for MRI‐guided radiotherapy (MRgRT) using dynamic keyhole imaging for high‐temporal acquisition and super‐resolution generative (SRG) model for high‐spatial reconstruction. Method We propose a unique real‐time 3D MRI technique by combining a data sharing technique (3D dynamic keyhole imaging) with a SRG model using cascaded deep learning technique. 3D dynamic keyhole imaging utilizes the data sharing mechanism by combining keyhole central k‐space data acquired in real‐time with high‐spatial, high‐temporal resolution prior peripheral k‐space data at various motion positions prepared by the SRG model. The efficacy of the 3D dynamic keyhole imaging with super‐resolution (SR_dKeyhole) was compared to the ground‐truth super‐resolution images with the original full k‐space data. It was also compared with the zero‐filling reconstruction (zero‐filling), conventional keyhole reconstruction with low‐spatial high‐temporal prior data (LR_cKeyhole), and conventional keyhole reconstruction with super‐resolution prior data (SR_cKeyhole). Results High‐spatial, high‐temporal resolution 3D MRI datasets (1.5 × 1.5 × 6 mm3) were generated from low‐spatial, high‐temporal resolution 3D MRI datasets (6 × 6 × 6 mm3) using the cascaded deep learning SRG framework (<100 ms/volume). 3D dynamic keyhole imaging with the SRG model provided high‐spatial, high‐temporal resolution images (1.5 × 1.5 × 6 mm3, 455 ms) with the highest similarity to the ground‐truth SR images without any noticeable artifacts. Structural similarity indices (SSIM) of the reconstructed 3D MRI to the original SR 3D MRI were 0.65, 0.66, 0.86, and 0.89 for zero‐filling, LR_cKeyhole, SR_cKeyhole, and SR_dKeyhole, respectively (1 for identical image). In addition, average value of image relative error (IRE) of the reconstructed 3D MRI to the original SR 3D MRI were 0.169, 0.191, 0.079, and 0.067 for zero‐filling, LR_cKeyhole, SR_cKeyhole, and SR_dKeyhole, respectively (0 for identical image). Conclusions We demonstrated that high‐spatial, high‐temporal resolution 3D MRI was feasible by combing 3D dynamic keyhole imaging with a SRG model in terms of image quality and imaging time. The proposed technique can be utilized for real‐time 3D MRgRT.

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“…The idea of using on‐board MR imaging to guide radiotherapy has surged in recent years and now the MRI‐Linac technology is getting close to clinical applications . With proper shielding to reduce the interference between the magnetic field and clinically used particle radiation to an insignificant level, MR images can be acquired during the treatment to monitor the motion of moving targets.…”

Section: Introductionmentioning

confidence: 99%