New Compounds. Some Chlorophenoxyacetic Acids

Pokorny, Robert

doi:10.1021/ja01851a601

Cited by 59 publications

(19 citation statements)

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“…Both phenylacetic acid and naphthylacetic acid were reported to demonstrate some of the same activities as IAA . The auxin herbicide 2,4‐D was actually first prepared as a potential fungicide, but subsequent testing by Zimmerman and Hitchcock identified a high degree of activity as a plant growth regulator . All of these researchers were pursuing the plant‐growth‐regulating activities of auxins at the time, and it was not until the near‐simultaneous insights of WG Templeman working in England and EJ Kraus working in the United States that the herbicide potential was realized.…”

Section: Herbicidesmentioning

confidence: 99%

Natural products for pest control: an analysis of their role, value and future

Gerwick¹,

Sparks²

2014

Pest Management Science

248

225

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Natural products (NPs) have long been used as pesticides and have broadly served as a source of inspiration for a great many commercial synthetic organic fungicides, herbicides and insecticides that are in the market today. In light of the continuing need for new tools to address an ever-changing array of fungal, weed and insect pests, NPs continue to be a source of models and templates for the development of new pest control agents. Interestingly, an examination of the literature suggests that NP models exist for many of the pest control agents that were discovered by other means, suggesting that, had circumstances been different, these NPs could have served as inspiration for the discovery of a great many more of today's pest control agents. Here, an attempt is made to answer questions regarding the existence of an NP model for existing classes of pesticides and what is needed for the discovery of new NPs and NP models for pest control agents.

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Section: Herbicidesmentioning

confidence: 99%

Natural products for pest control: an analysis of their role, value and future

Gerwick¹,

Sparks²

2014

Pest Management Science

248

225

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“…As was shown in the diagram above, the synthesis of 2,4-D is based on two subsequent reactions of chlorination and condensation. This method is used by producers of 2,4-D in all countries, invariably since the first synthesis published in 1941 by J. Pokorny (Pokorny, 1941). Below, this technology is referred to as "classical".…”

Section: 4-dmentioning

confidence: 99%

Ecological Production Technology of Phenoxyacetic Herbicides MCPA and 2,4-D in the Highest World Standard

Moszczyński¹,

Białek²

2012

Herbicides - Properties, Synthesis and Control of Weeds

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“…In 1941, the synthesis of 2,4-dichlorophenoxy acetic acid (2,4-D) was reported [14]. This compound was shown to affect plant growth via auxin-like activity [15], its plant selectivity was examined [16] and its use as a weed control agent under field conditions was established [17].…”

Section: Introductionmentioning

confidence: 99%

Interactions of Auxinic Compounds on Ca2+ Signaling and Root Growth in <i>Arabidopsis thaliana</i>

Teaster¹,

Sparks²,

Blancaflor³

et al. 2015

AJPS

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Auxinic-like compounds have been widely used as weed control agents. Over the years, the modes of action of auxinic herbicides have been elucidated, but most studies thus far have focused on their effects on later stages of plant growth. Here, we show that some select auxins and auxiniclike herbicides trigger a rapid elevation in root cytosolic calcium levels within seconds of application. Arabidopsis thaliana plants expressing the Yellow-Cameleon (YC) 3.60 calcium reporter were treated with indole-3-acetic acid (IAA), indole-3-butyric acid (IBA), 1-naphthalene acetic acid (NAA), and two synthetic herbicides, 2,4-dichlorophenoxyacetic acid (2,4-D) and mecoprop [2-(4-chloro-2-methylphenoxy) propanoic acid], followed by monitoring cytosolic calcium changes over a 10 minute time course. Seconds after application of compounds to roots, the Ca 2+ signaling-mediated pathway was triggered, initiating the plant response to these compounds as monitored and recorded using Fluorescence Resonance Energy Transfer (FRET)-sensitized emission imaging. Each compound elicited a specific and unique cytosolic calcium signature. Also primary root development and elongation was greatly reduced or altered when exposed at two concentrations (0.10 and 1.0 µM) of each compound. Within 20 to 25 min after triggering of the Ca 2+ signal, root growth inhibition could be detected. We speculate that differences in calcium signature among the tested auxins and auxinic herbicides might correlate with their variation and potency with regard to root growth inhibition.

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New Compounds. Some Chlorophenoxyacetic Acids

Cited by 59 publications

References 0 publications

Natural products for pest control: an analysis of their role, value and future

Natural products for pest control: an analysis of their role, value and future

Ecological Production Technology of Phenoxyacetic Herbicides MCPA and 2,4-D in the Highest World Standard

Interactions of Auxinic Compounds on Ca2+ Signaling and Root Growth in <i>Arabidopsis thaliana</i>

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New Compounds. Some Chlorophenoxyacetic Acids

Cited by 59 publications

References 0 publications

Natural products for pest control: an analysis of their role, value and future

Natural products for pest control: an analysis of their role, value and future

Ecological Production Technology of Phenoxyacetic Herbicides MCPA and 2,4-D in the Highest World Standard

Interactions of Auxinic Compounds on Ca2+ Signaling and Root Growth in &lt;i&gt;Arabidopsis thaliana&lt;/i&gt;

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Interactions of Auxinic Compounds on Ca2+ Signaling and Root Growth in <i>Arabidopsis thaliana</i>