New combined surgery for cervical cancer complicated by pelvic organ prolapse using autologous fascia lata: A case report

Ota, Yoshihide; Suzuki, Yukio; Matsunaga, Tomoko; Ninomiya, Ryunosuke; Kagimoto, Shintaro

doi:10.1002/ccr3.2883

Cited by 4 publications

(7 citation statements)

References 19 publications

(20 reference statements)

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“…There are many treatment modalities for POP, include pessary, reconstructive pelvic surgery with mesh, sacral colpopexy, colocalizes [10] and autologous tissue repair [11]. Treatment options that were reported of the complex comorbidities in recent years include pessary followed by perineorrhaphy and chemoradiotherapy [12], vaginal hysterectomy with pelvic node dissection followed by radiation therapy [13], total vaginal hysterectomy, trans ventral cancer staging and intraabdominal uterosacral ligament suspension [14], radical hysterectomy and immediate sacral colpopexy with an autologous fascia Lata (RISA) graft [15], even palliative chemotherapy (combined terminal cervical carcinoma) [16]. However, the surgical-based treatment in our index patient seemed to be a more favorable treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

Cervical Cancer in Case with Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI)

Qiao

Ran

Qi-xin

et al. 2023

wjcm

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Background: Combined cervical cancer and pelvic organ prolapse (POP) is extremely uncommon and there is no standard treatment guideline for the complex comorbidity. We attempted to provide a treatment strategy and explore possible reasons for the comorbidities. Case presentation: We presented a 62-year-old patient seeking treatment for postmenopausal tissue prolapse and leakage of urine. The gynecologic examination revealed the uterine prolapse with a 2.5 cm papillary and erosive lesion on the cervix that was pathologically confirmed as cervical squamous cell carcinoma in stage Ib1. Clinical diagnosis included cervical squamous cell carcinoma in stage Ib1, prolapse of uterus and vagina, stress urinary incontinence (SUI). Then she was performed radical surgery for cervical cancer and tension-free vaginal tape-obturator (TVT-O). The urine function was good after operation. The surgery solved two diseases, which improved the quality of life (QOL) of patient and radically cured cervical carcinoma at the same time. Follow up for more than two years, HPV was negative, no prolapse symptoms occurred, and the quality of life was good. Conclusions: Surgical-based treatment seems to be more suitable that can cure the two diseases and improve the QOL. We should pay attention to the potential high incidence of HPV infection and HPV-related cervical cancer so that we should not ignore the screening for cervical cancer in the prolapse group and initiate surgery treatment strategies of cervical cancer or pre-cancerous lesions as early as possible to reach an optimal outcome of patient.

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Section: Discussionmentioning

confidence: 99%

Cervical Cancer in Case with Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI)

Qiao

Ran

Qi-xin

et al. 2023

wjcm

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show abstract

“…Firstly, the radical surgery cervical solved the cervical cancer and prolapse of middle pelvic cavity and the following TVT-O relieved the urinary symptoms, meanwhile, our large enough resection extent that included 4-5cm vaginal wall and in addition to subsequent suture of vaginal residue, the remaining vagina of the patient was very short, which had addressed the prolapse of vaginal wall in a sense. Secondly, tumor regression and organ motion can affect the radiation dose, and cysto-rectocele may increase the risk of visceral radiation injury that lowers QOL if we choose radiotherapy or concurrent chemoradiotherapy, although it may be less invasive [12] . Finally, surgery-based treatment may have a positive effect on survival outcome according to the past two system review [4,14].…”

Section: Discussionmentioning

confidence: 99%

“…There are many treatment modalities for POP, include pessary, reconstructive pelvic surgery with mesh, sacral colpopexy, colpocleisis [7] and autologous tissue repair [8]. Treatment options that were reported of the complex comorbidities in the recent years included a pessary using followed by perineorrhaphy and chemoradiotherapy [9], vaginal hysterectomy with pelvic node dissection followed by radiation therapy [10], total vaginal hysterectomy, transventral cancer staging and intraabdominal uterosacral ligament suspension [11], radical hysterectomy and immediate sacral colpopexy with an autologous fascia lata (RISA) graft [12], even palliative chemotherapy (combined terminal cervical carcinoma) [13]. However, the surgical-based treatment in our index patient seems to be a more favorable treatment strategy.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Radical Hysterectomy and Tension-Free Vaginal Tape-Obturator (TVT-O) Combined to Treat Cervical Cancer Complicating Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI): A Case Report

Ran

Liu

et al. 2021

Preprint

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Background: Combined cervical cancer and pelvic organ prolapse (POP) is extremely uncommon and there is no standard treatment guideline for the complex comorbidity. We attempted to provide a treatment strategy and explore possible reasons for the comorbidities.Case presentation: We presented a 62-year-old patient seeking treatment for postmenopausal tissue prolapse and leakage of urine, physical examination revealed procidentia with a 2.5 cm papillary and erosive lesion that was pathologically confirmed as cervical squamous cell carcinoma in stage Ib2. Clinical diagnosis included cervical squamous cell carcinoma in stage Ib2, prolapse of the anterior and posterior walls of the vagina and uterine, stress urinary incontinence (SUI), and then she was performed radical surgery for cervical cancer and tension-free vaginal tape-obturator (TVT-O), the urine function was good after operation. The surgery solved two diseases at the same time that improve the QOL of patients while radically curing cervical malignancies.Conclusions: Surgical-based treatment seems to be more suitable that can cure the two diseases and improve the QOL. We should pay attention to the potential high incidence of HPV infection and HPV-related cervical cancer so that don't ignore the screening for cervical cancer in the prolapse group and initiate surgery treatment strategies of cervical cancer or pre-cancerous lesions as early soon as possible to reach an optimal outcome of patient.

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“…[4] Correction of this pathology may be a part of the surgical treatment of this tumour. [5][6][7][8][9]…”

Section: Introductionmentioning

confidence: 99%

Synchronous occurrence of HPV-associated cervical squamous cell carcinoma (FIGO IIA) in prolapsed uterus and adenocarcinoma of the anal canal cT1N0M0

Trawińska¹,

Bielatowicz²,

Książek³

et al. 2021

Medicine

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Rationale: Guidelines of rare synchronous tumours treatment are often unavailable due to lack of wide prospective studies. Additionally, their management is not just a simple sum of coexisting tumours management and has to regard many circumstances like symptoms, age, comorbidities, advancement. Patient concerns: Herein, we report a case of an 81-year-old woman who presented with bleeding from the prolapsed uterus. Diagnoses: Based on physical examination, that is, speculum examination, bimanual, and per rectum, followed by rectoscopy and histopathology, the diagnosis of cervical squamous cell carcinoma FIGO IIA2 in prolapsed uterus with anal canal adenocarcinoma cT1N0M0 was made. Interventions: Dominating complaint of bleeding from prolapsed cervix was managed with radical vaginal hysterectomy in conjunction with wide colpectomy preceded by laparoscopic pelvic and paraaortic lymphadenectomy. Due to the lack of consent for removal of the anus, only radiotherapy was applied instead. Outcomes: The patient underwent magnetic resonance image follow-up. No recurrence was found at 18 months. Lessons: Imaging is useful method of synchronous cancers diagnostics. These cancers may vary in aetiology and stage. Cervical cancer may be co-existing with another anogenital cancer. Therapy of synchronous cancers should be individualized taking into account patient's consent, age, physical condition, and comorbidities.

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New combined surgery for cervical cancer complicated by pelvic organ prolapse using autologous fascia lata: A case report

Abstract: Radical hysterectomy and immediate sacral colpopexy using autologous fascia lata could be considered a treatment option for cervical cancer complicated by severe and symptomatic pelvic organ prolapse.

Cited by 4 publications

References 19 publications

Cervical Cancer in Case with Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI)

Cervical Cancer in Case with Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI)

Laparoscopic Radical Hysterectomy and Tension-Free Vaginal Tape-Obturator (TVT-O) Combined to Treat Cervical Cancer Complicating Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI): A Case Report

Synchronous occurrence of HPV-associated cervical squamous cell carcinoma (FIGO IIA) in prolapsed uterus and adenocarcinoma of the anal canal cT1N0M0

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