New colour reagents for the analysis of alkylating agents

Stücker, W.; Golovinsky, Evgeny; Müller, Günther; Oberst, M.; Maher, Kevin; Norpoth, K.

doi:10.1007/bf00494533

Cited by 1 publication

(2 citation statements)

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“…A few spectrophotometric 3,4 or fluorimetric 5,6 reagents other than NBP have been proposed, but none appears to be in general use. Disadvantages of all of these reagents are that considerable method development is required for each matrix, and methods are tedious.…”

Section: Introductionmentioning

confidence: 99%

“…Gaseous ammonia has been used as a derivatisation agent for dimethyl sulfate in fly ash, 7 the resulting methylamine being determined by ion chromatography (it could not be analysed by headspace GC). A method involving tritium release from [8- 3 H]guanine-labeled DNA 8 is probably the most sensitive available, but the use of a radioisotope and the need to operate at physiological pH limit its general usefulness.…”

Section: Introductionmentioning

confidence: 99%

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Determination of polar alkylating agents as thiocyanate/isothiocyanate derivatives by reaction headspace gas chromatography

Lee

Guivarch

Dau

et al. 2003

Analyst

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We report a new method for the determination of the methyl, ethyl and isopropyl esters of methanesulfonic acid, and of dimethyl sulfate. Derivatisation with aqueous sodium thiocyanate gives a mixture of the corresponding alkylthiocyanates and alkylisothiocyanates which, unlike the underivatised analytes, are readily analysed by GC. On-column isomerisation is negligible. These lower alkyl derivatives are sufficiently volatile for static reaction headspace analysis, and detection limits obtained by electron impact MS are below 0.05 µg ml 21 with respect to the injection solution. The method was used to demonstrate that levels of methanesulfonic acid esters in a drug substance (a mesylate salt that had been processed using methanol and ethanol) are below 1 µg g 21 .

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