New classifications of epilepsies and seizure types created by the International League against Epilepsy (2017)

Makushkin, Ye. V.; Осколкова, Софья Натановна; Fastovtsov, G.

doi:10.17116/jnevro201711771107-111

Cited by 2 publications

(1 citation statement)

References 29 publications

(36 reference statements)

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“…The types of seizures experienced by the patients were determined based on reports from caregivers and documentation from video-EEG monitoring. These were then analyzed and categorized according to the 2017 International League Against Epilepsy classification system [14]. Tonic seizures, a common type of seizure in patients with LGS, often occur during sleep.…”

Section: Seizure Classificationmentioning

confidence: 99%

Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome

Park,

Kwon,

Koo

et al. 2024

Ann Child Neurol

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Purpose: This study examined the characteristics and outcomes of resective epilepsy surgery following corpus callosotomy (CC) in children with Lennox-Gastaut syndrome (LGS).Methods: We retrospectively analyzed 17 children with LGS who underwent resective surgery (RS) after CC over a span of 10 years, with a minimum of 2 years of follow-up, at a single tertiary epilepsy center in Korea.Results: Of the 17 patients, 13 (73.5%) demonstrated favorable surgical outcomes (Engel class I or II) at 1 year after RS, and eight (47.1%) were ultimately free of seizures 2 years after surgery. A significantly larger decrease in the number of anti-seizure medications taken from before to 2 years after the final surgical procedure was observed in the group that became seizure-free than in the group with persistent seizures (<i>P</i>=0.062). Furthermore, a significantly greater decline in daily adaptive function was found in the persistent seizure group (<i>P</i>=0.059). The baseline characteristics, results of presurgical evaluation, and treatment-related factors assessed prior to surgery showed no significant differences between the seizure-free group and the group with persistent seizures.Conclusion: In conclusion, RS may be a viable option for patients with LGS who exhibit lateralization and/or localization on presurgical evaluation after CC, as the procedure may reveal a concealed primary focus. The proactive implementation of two-stage epilepsy surgery could provide significant seizure reduction and preservation of cognitive function in carefully selected patients with LGS.

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Section: Seizure Classificationmentioning

confidence: 99%

Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome

Park,

Kwon,

Koo

et al. 2024

Ann Child Neurol

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Biological Reductionism as an Obstacle to the Advancement of the Biopsychosocial Concept of Mental Disorders

Kotsyubinsky,

Kotsyubinsky

2023

Consortium Psychiatricum

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The substantial progress in neurobiological technologies has narrowed the horizons of many psychiatrists, ultimately leading them to focus exclusively on biomedical research, primarily aimed at studying the biological basis of mental illnesses. This has led to an unjustified dominance of the biomedical paradigm in understanding the nature of mental disorders, while virtually ignoring the study of other components of the disease related to the psychosocial maladjustment of patients. This trend, largely associated with advancements in neuroscience employing neuroimaging techniques to study the brain’s activity as a biophysical object, has contributed to the development of such innovative field as evidence-based medicine. The methods of evidence-based medicine are seen as adequate in terms of determining the effectiveness of therapy for predominantly biologically determined components of mental illness (including the selection of medications) and only partially for psychological interventions. However, it seems that the predominant use of evidence-based medicine principles is insufficient for a holistic diagnostic approach, which includes a multilevel (diversified) representation of the criteria of effectiveness for pharmacological and psychological interventions. In this regard, it is promising to establish a scientifically and clinically productive combination of, on the one hand, the evidence-based concept of effectiveness assessments based on high-quality randomized scientific studies, and on the other, expert opinions of highly qualified scientific specialists, as well as practicing physicians with their personal professional experience in individualized therapy. This makes it reasonable to develop a personality-oriented personalized psychiatry, based on a biopsychosocial understanding of the nature of mental disorders, their holistic assessment, and the development of comprehensive therapeutic measures.

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New classifications of epilepsies and seizure types created by the International League against Epilepsy (2017)

Cited by 2 publications

References 29 publications

Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome

Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome

Biological Reductionism as an Obstacle to the Advancement of the Biopsychosocial Concept of Mental Disorders

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