New classification criteria for systemic lupus erythematosus correlate with disease activity

Abstract

AimTo determine the prevalence of American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) classification criteria among systemic lupus erythematosus (SLE) patients; to determine disease activity and severity; and to investigate the correlation of classification criteria with disease activity, and of disease activity and damage index with disease duration.MethodsWe performed a cross-sectional study on 110 SLE patients from the Division of Rheumatology and Clinical Immunology, University Hospital Centre Rijeka, Croatia in the period from September to December 2013 and determined disease duration and the total number of ACR and SLICC classification criteria. Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) index and organ damage by Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index.ResultsThe number of SLICC classification criteria met per patient was significantly higher than the number of ACR criteria (7 [IQR 6-8] vs 5 [IQR 4-6], P < 0.001). Moderate correlations were detected between the number of SLICC classification criteria and disease activity index, both in case of active (r = 0.48, P = 0.003) and inactive disease (r = 0.43, P < 0.001). We neither found a correlation between the number of ACR criteria and disease activity nor between disease activity and disease duration. However, there was a good correlation between SLICC/ACR damage index and disease duration (r = 0.63, P < 0.001).ConclusionNew SLICC classification criteria correlate with disease activity because they capture more manifestations also included in the SLEDAI index. Patients with longer disease duration had a larger damage index score.

SLICC 12 Criteria Are More Effectiveness than ACR 97 Score about Systemic Lupus Erythematosus Diagnosis

“…Anic [3] demonstrate a correlation between SLEDAI -Systemic Lupus Erythematosus Disease Activity Index, which is used to measure disease activity index, and the new SLICC 12 for both active and inactive diseases by capturing the same clinical and laboratory findings, however when correlated with ACR 97 there was no correlation.…”

“…In 2012, the SLICC group -Systemic Lupus International Collaborating Clinics proposed a new set of classification criteria, consisting of eleven (11) clinical criteria, six (6) immunological criteria and one alternative, where the patient must meet at least four) of seventeen (17) criteria [3].…”

Perbandingan Diagnosis Systemic Lupus Erythematosus Menggunakan Kriteria American College of Rheumatologi dan Systemic Lupus International Collaborating Clinics

“…Antibody anti-nuclear serum, antibodi anti ds-DNA dan antibodi anti-Sm merupakan biomarker yang penting untuk penegakkan diagnosis SLE berdasarkan kriteria ACR. [3][4][5] Kriteria klasifikasi ACR pada pasien anak memiliki banyak kelemahan. Kriteria ini telah banyak dikembangkan dan divalidasi pada pasien dewasa, tetapi tidak demikian pada populasi anak.…”

“…Berdasarkan kriteria SLICC, pasien harus memenuhi sekurangnya 4 dari 17 kriteria, termasuk sekurangnya terdapat satu kriteria klinis dan satu kriteria imunologis. 3,4 Kriteria SLICC dibandingkan dengan kriteria ACR mempunyai sensitivitas lebih tinggi dan spesifisitas yang setara. Dengan demikian, diharapkan kriteria SLICC dapat digunakan sebagai kriteria diagnosis yang lebih baik dibandingkan kriteria yang dipakai sebelumnya untuk mengidentifikasi pasien anak dengan SLE.…”

“…Dengan demikian, diharapkan kriteria SLICC dapat digunakan sebagai kriteria diagnosis yang lebih baik dibandingkan kriteria yang dipakai sebelumnya untuk mengidentifikasi pasien anak dengan SLE. 3 Penelitian ini bertujuan membandingkan kriteria ACR dan kriteria SLICC dalam menegakkan diagnosis SLE pada anak dan menilai kesepakatan (agreement) di antara kedua kriteria tersebut.…”