New Class of Efficient T2 Magnetic Resonance Imaging Contrast Agent: Carbon-Coated Paramagnetic Dysprosium Oxide Nanoparticles

Yue, Huan; Park, Ji Ae; Ho, Son Long; Ahmad, Mohammad Yaseen; Cha, Hyunsil; Liu, Shuwen; Tegafaw, Tirusew; Marasini, Shanti; Ghazanfari, Adibehalsadat; Kim, Soyeon; Chae, Kwon Seok; Chang, Yongmin; Lee, Gang Ho

doi:10.3390/ph13100312

Cited by 10 publications

(13 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: T2-weighted Mrimentioning

confidence: 99%

“…Recently, Ln2O3 (Ln = Tb, Dy, and Ho) nanoparticles with appreciable r2 and negligible r1 values, suitable for T2 MRI were developed [42,43,50,66,79,80]. For example, PAAcoated Ln2O3 (Ln = Tb and Ho) nanoparticles exhibited appreciable r2 values at 3.0 T MR field (3.19 s −1 mM −1 for Ln = Tb and 1.44 s −1 mM −1 for Ln = Ho), enhanced r2 values at 9.4 T MR field (16.40 s −1 mM −1 for Ln = Tb and 9.20 s −1 mM −1 for Ln = Ho) [43], and negligible r1 values at all MR fields.…”

Section: T2-weighted Mrimentioning

confidence: 99%

“…Recently, Ln 2 O 3 (Ln = Tb, Dy, and Ho) nanoparticles with appreciable r 2 and negligible r 1 values, suitable for T 2 MRI were developed [42,43,50,66,79,80]. For example, PAA-coated [80]. The nanoparticles were nearly non-toxic via an in vitro cellular cytotoxicity assay.…”

Section: T 2 -Weighted Mrimentioning

confidence: 99%

“…(Figure 15a), proving the potential of Dy2O3 nanoparticles as T2 MRI contrast agents. Recently, Yue et al investigated carbon-coated Dy2O3 nanoparticles as a new class of T2 MRI contrast agent at 3.0 T MR field [80]. The nanoparticles were nearly non-toxic via an in vitro cellular cytotoxicity assay.…”

Section: T 2 -Weighted Mrimentioning

confidence: 99%

See 3 more Smart Citations

Functionalized Lanthanide Oxide Nanoparticles for Tumor Targeting, Medical Imaging, and Therapy

et al. 2021

Self Cite

View full text Add to dashboard Cite

Recent progress in functionalized lanthanide oxide (Ln2O3) nanoparticles for tumor targeting, medical imaging, and therapy is reviewed. Among the medical imaging techniques, magnetic resonance imaging (MRI) is an important noninvasive imaging tool for tumor diagnosis due to its high spatial resolution and excellent imaging contrast, especially when contrast agents are used. However, commercially available low-molecular-weight MRI contrast agents exhibit several shortcomings, such as nonspecificity for the tissue of interest and rapid excretion in vivo. Recently, nanoparticle-based MRI contrast agents have become a hot research topic in biomedical imaging due to their high performance, easy surface functionalization, and low toxicity. Among them, functionalized Ln2O3 nanoparticles are applicable as MRI contrast agents for tumor-targeting and nontumor-targeting imaging and image-guided tumor therapy. Primarily, Gd2O3 nanoparticles have been intensively investigated as tumor-targeting T1 MRI contrast agents. T2 MRI is also possible due to the appreciable paramagnetic moments of Ln2O3 nanoparticles (Ln = Dy, Ho, and Tb) at room temperature arising from the nonzero orbital motion of 4f electrons. In addition, Ln2O3 nanoparticles are eligible as X-ray computed tomography contrast agents because of their high X-ray attenuation power. Since nanoparticle toxicity is of great concern, recent toxicity studies on Ln2O3 nanoparticles are also discussed.

show abstract

Section: T2-weighted Mrimentioning

confidence: 99%

Section: T2-weighted Mrimentioning

confidence: 99%

Section: T 2 -Weighted Mrimentioning

confidence: 99%

Section: T 2 -Weighted Mrimentioning

confidence: 99%

See 2 more Smart Citations

Functionalized Lanthanide Oxide Nanoparticles for Tumor Targeting, Medical Imaging, and Therapy

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…An improved modification of cobalt ferrite contrast agent has been carried out, doping with europium and encapsulated into mesoporous silica [ 20 ]. Novel T 2 contrast agent materials recently published are focused on carbon-coated paramagnetic dysprosium oxide (DYO@C) nanoparticles [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient T2 Cobalt Ferrite Nanoparticles Vectorized for Internalization in Cancer Cells

et al. 2021

View full text Add to dashboard Cite

Uniform cobalt ferrite nanoparticles have been synthesized using an electrochemical synthesis method in aqueous media. Their colloidal, magnetic, and relaxometric properties have been analyzed. The novelty of this synthesis relies on the use of iron and cobalt foils as precursors, which assures the reproducibility of the iron and cobalt ratio in the structure. A stable and biocompatible targeting conjugate nanoparticle-folic acid (NP-FA) was developed that was capable of targeting FA receptor positivity in HeLa (human cervical cancer) cancer cells. The biocompatibility of NP-FA was assessed in vitro in HeLa cells using the MTT assay, and morphological analysis of the cytoskeleton was performed. A high level of NP-FA binding to HeLa cells was confirmed through qualitative in vitro targeting studies. A value of 479 Fe+Co mM−1s−1 of transverse relaxivity (r2) was obtained in colloidal suspension. In addition, in vitro analysis in HeLa cells also showed an important effect in negative T2 contrast. Therefore, the results show that NP-FA can be a potential biomaterial for use in bio medical trials, especially as a contrast agent in magnetic resonance imaging (MRI).

show abstract

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Antwi-Baah

Wang

Chen

et al. 2022

Adv Materials Inter

View full text Add to dashboard Cite

Over the years, several imaging techniques have been developed to improve alreadyexisting ones, thus, overcoming the obstacles that previous ones failed to overcome. Recently, much energy has been put into developing tools that complement the ability of the current imaging techniques. Imaging probe or contrast agent is one of the well-known tools in this category, which enhance the conspicuousness of images. Researchers have taken the opportunity to work tirelessly on developing imaging probes, which have gone a long way in attaining biological and functional image details of a biological system when used alongside existing imaging techniques. With the advantage of displaying a more detailed view for analyzing biological information and diagnosing diseases, imaging probes are undoubtedly a significant research field in biological and medical sciences.Molecular imaging, a term describing the visualization of specific molecules and molecular transformations that occur during disease activity in a living system using radiological and nuclear medicine, [2] has recently received enormous attention. A tissue or organ is diseased when it depicts characteristics that deviate from its normal functionality or organization. The diseased condition is stimulated by many biochemical processes involving internal and external stimuli from within the cell. Molecular imaging serves as a diagnostic tool for detecting abnormal disease molecules early because it can examine the biochemical adjustments as a normal tissue mutates into a diseased one. Representative imaging techniques include magnetic particle imaging (MPI), [3] positron emission tomography (PET), single-photon emission computed tomography (SPECT), optical imaging, magnetic resonance imaging (MRI), computed tomography (CT) and, ultrasound. [4] These imaging techniques are noninvasive diagnostic platforms that bridge the gap between molecular biology and molecular medicine. They allow examining a living organism to verify effects on multiple organ systems in vivo and help diagnose diseases at preclinical stages. These imaging techniques employ tracers or contrast agents to improve sensitivity. MPI is a tracer imaging modality that instantaneously quantifies the concentration and Metal-based nanoparticles, especially gadolinium, manganese, and iron, have gained ground in the research of magnetic resonance imaging (MRI) contrast agents. Over the years, contrast agents based on these paramagnetic and superparamagnetic nanomaterials have merited keen attention in the biomedical field due to their desired properties such as sizeable magnetic susceptibility, tunable size, easy surface functionalization, low toxicity, etc. Gadolinium-based chelates are the traditional MRI contrast agents in the clinic but require improved relaxivities and pharmacokinetics. Nanoparticles possess a larger surface area, demonstrate a longer retention time in the body, and allow the conjugation of several functional molecules to enhance tumor targeting, making them more advantageous. The pursuit o...

show abstract

New Class of Efficient T2 Magnetic Resonance Imaging Contrast Agent: Carbon-Coated Paramagnetic Dysprosium Oxide Nanoparticles

Cited by 10 publications

References 55 publications

Functionalized Lanthanide Oxide Nanoparticles for Tumor Targeting, Medical Imaging, and Therapy

Functionalized Lanthanide Oxide Nanoparticles for Tumor Targeting, Medical Imaging, and Therapy

Highly Efficient T2 Cobalt Ferrite Nanoparticles Vectorized for Internalization in Cancer Cells

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Contact Info

Product

Resources

About