New cinnamic acid derivatives with potential neuroprotective activities from the stems of Melicope ptelefolia

Wu, Shou-Yuan; Chen, Ziming; Zhou, Zhongliu; Huang, Guoling; Zhou, Qi; Xi, Yanjie

doi:10.1016/j.phytol.2022.12.010

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…Aside from the fact that cinnamic acid itself has various types of activity, it has many derivatives: no less valuable substances that also have a wide range of pharmacological activities, such as antibacterial [37], antifungal [38], neuroprotective [39], and anticancer effects [40]. For this reason, they have been separated into an independent class of biologically active substances and have affected the chemical classification of medicinal plants.…”

Section: Phenolic Acidsmentioning

confidence: 99%

“…Numerous pharmacological studies have shown that benzoic acid derivatives that contain, for example, a carboxyl group is promising as potential diuretics, and carbamide derivatives hold promise as analgesics [42]. In the extract analyzed here, benzoic acid derivatives are represented by 2-methylbenzoic acid (26), 2,4-dihydroxybenzoic acid (31), 4-aminobenzoic acid ( 23), and 5-carboxyvanillic acid (39).…”

Section: Phenolic Acidsmentioning

confidence: 99%

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Chemical Composition of Methanol Extracts from Leaves and Flowers of Anemonopsis macrophylla (Ranunculaceae)

Kostikova,

Petrova,

Chernonosov

et al. 2024

IJMS

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Anemonopsis Siebold et Zucc. is an unstudied single-species genus belonging to the tribe Cimicifugeae (Ranunculaceae). The only species of this genus—Anemonopsis macrophylla Siebold and Zucc.—is endemic to Japan. There are no data on its chemical composition. This work is the first to determine (with liquid chromatography–high-resolution mass spectrometry, LC-HRMS) the chemical composition of methanol extracts of leaves and flowers of A. macrophylla. More than 100 compounds were identified. In this plant, the classes of substances are coumarins (13 compounds), furocoumarins (3), furochromones (2), phenolic acids (21), flavonoids (27), and fatty acids and their derivatives (15 compounds). Isoferulic acid (detected in extracts from this plant) brings this species closer to plants of the genus Cimicifuga, one of the few genera containing this acid and ferulic acid at the same time. Isoferulic acid is regarded as a reference component of a quality indicator of Cimicifuga raw materials. The determined profiles of substances are identical between the leaf and flower methanol extracts. Differences in levels of some identified substances were revealed between the leaf and flower extracts of A. macrophylla; these differences may have a substantial impact on the manifestation of the biological and pharmacological effects of the extracts in question.

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