New Cholinesterase Inhibiting Steroidal Alkaloids from the Leaves of Sarcococca coriacea of Nepalese Origin.

Abstract

Alkaloids Alkaloids U 0600New Cholinesterase Inhibiting Steroidal Alkaloids from the Leaves of Sarcococca coriacea of Nepalese Origin. -From the dried aerial parts of the title plant the two novel compounds (I) and (II) together with two known substances are isolated from the methanol extract. -(KALAUNI, S. K.; CHOUDHARY*, M. I.; KHALID, A.; MANANDHAR, M. D.; SHAHEEN, F.; ATTA-UR-RAHMAN; GEWALI, M. B.; Chem.

In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora

“…AChE inhibitors are the most effective approach to treat the cognitive symptoms of Alzheimer disease (AD) (Kalauni et al 2002) and other possible therapeutic applications in the treatment of Parkinson's disease, senile dementia, and ataxia, among others (Ahmad et al 2003a). AChE inhibitors as eserine, tacrine, donepezil, rivastigmine, and galanthamine are the only drugs currently approved for the treatment of AD; however, these drugs are known to have limitations for clinical use due to their short-half-lives and/or unfavorable side-effects (Sung et al 2002).…”

In vitro antioxidant, anti-hyperglycemic, anti-cholinesterase, and inhibition of nitric oxide production activities of methanol and hot water extracts of Russula rosacea mushroom

“…The activities of AChE sometimes lead to several neurological disorders such as Alzheimer's disease, senile dementia, and ataxia (Kalauni et al, 2002). The AChE inhibitory activity of methanol, and hot water extracts from R. rosacea fruiting bodies were investigated.…”

“…AChE inhibitors can increase cholinergic transmission by preventing the hydrolysis of released ACh, thus making more ACh available at the cholinergic synapse (Benzi and Morreti, 1998). This makes AChE inhibitors the most effective means to treat the cognitive symptoms of Alzheimer's disease (Kalauni et al, 2002). AChE inhibitors such as physostigmine, tacrine, donepezil, rivastigmine, and galanthamine are the only currently available drugs for the treatment of AD.…”

Structure Based 3D-QSAR Studies on Cholinesterase Inhibitors

“…The cholinesterase inhibitory activities, represented by IC 50 (μM), were obtained from recently published data (Atta ur, Choudhary, 2000, Atta ur et al, 2003, Atta ur et al, 1997, Atta ur, Zaheer ul, 2002, Kalauni, Choudhary, 2001 (Table 1). The structures of inhibitors are presented in Table 2.…”

“…The discovery of natural cholinesterase inhibitors has been a very challenging area of drug development due to the involvement of cholinesterases in Alzheimer's disease and other related dementias. We have previously reported a number of new natural inhibitors of cholinesterases (AChE and BuChE) isolated from indigenous medicinal plants (Atta ur et al, 2000, Atta ur et al, 2002, Kalauni et al, 2001. The steady state inhibition kinetics, pharmacological profiles, SAR and molecular docking studies have been conducted on a similar series of compounds for AChE inhibition , Zaheer-Ul-Haq et al, 2003.…”