New chlorinated peptides from the tropical marine sponge Dysidea sp.

Stapleton, Bronwin; Cameron, George M.; Garson, Mary J.

doi:10.1016/s0040-4020(01)00379-9

Cited by 23 publications

(9 citation statements)

References 23 publications

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“…214 From the same collection, several polychlorinated dipeptides 305-309 were reported separately; the absolute stereochemistries were determined by comparison of optical rotation data. 215 The methyl esters 305-307 are considered to be artifacts of methanolic extraction. An undescribed species of Dysidea collected in the Philippines yielded the proline-derived dysideaprolines A-F 310-315 together with the enol-ether containing barbaleucamides A 316 and B 317.…”

Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2002

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This review covers the literature published in 2001 for marine natural products, with 497 citations (373 for the period January to December 2001) and includes 793 compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red algae, sponges, coelenterates, bryozoans, molluscs, tunicates and echinoderms. The emphasis is on new compounds and new stereochemical assignments (683 for 2001), together with relevant biological activities, source organisms and country of origin. Syntheses that confirm or revise structures or stereochemistries have been included (95), including any first total synthesis of a marine natural product.

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Section: Spongesmentioning

confidence: 99%

Marine natural products

et al. 2002

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“…1 The genus Dysidea (order Dictyoceratida, family Dysideidae) is known as a rich source of diverse classes of secondary metabolites. 2 About 300 compounds, such as terpenoids, [3][4][5] steroids, 6,7 peptides 8,9 and polychlorinated metabolites, [10][11][12] were isolated from the genus Dysidea. Many of them have significant bioactivities, such as antibacterial, 9,[13][14][15] anti-inflammatory 16 and cytotoxic.…”

Section: Introductionmentioning

confidence: 99%

Two novel alkaloids from the South China Sea marine sponge Dysidea sp.

Ren

Tian

et al. 2010

J Antibiot

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“…These characteristics make sponges excellent organisms in which to study variation in the production of secondary metabolites and the relationship between environmental factors and symbionts. Sponges of the genus Dysidea produce a high diversity of secondary metabolites including terpenes, sterols, chlorinated amino acids, alkaloids and polybrominated diphenyl ethers (Dunlop et al 1982, Carmeli et al 1988, Fu & Schmitz 1996, Bandaranayake et al 1997, Cameron et al 2000, Stapleton et al 2001see Venkateswarlu et al 1998 for a review of the extensive literature on secondary metabolites isolated from Dysidea spp.). The secondary chemistry of the tropical species D. herbacea has been extensively investigated.…”

Section: Introductionmentioning

confidence: 99%

Effects of depth and light on secondary metabolites and cyanobacterial symbionts of the sponge Dysidea granulosa

Becerro¹,

Paul²

2004

Mar. Ecol. Prog. Ser.

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The tropical sponge Dysidea granulosa contains a number of symbiotic heterotrophic bacteria and large quantities of the photosynthetic cyanobacterium Oscillatoria spongeliae, which are reported to be responsible for the production of ecologically active polybrominated diphenyl ethers (BDEs) in Dysidea spp. In order to better understand the relationship between these symbionts and the production of BDEs, we looked at the variation in secondary chemistry in 3 populations of D. granulosa and the relationship between cyanobacteria and secondary chemistry in the sponge, and experimentally assessed the role that depth and light play in this relationship by transplanting sponges in the field. At a population scale, the concentration of BDEs is positively correlated with the concentration of chlorophyll a (chl a), both varying significantly between populations. Yet, in sponges experimentally transplanted to a deeper site, the concentration of chl a decreased significantly while BDE concentration remained stable. We specifically tested the importance of light in determining levels of symbionts and BDEs by placing sponges under transparent, UV-opaque, and black Plexiglas plates. After 5 wk, levels of BDEs and chl a had decreased significantly, although these trends differed between light treatment, suggesting a lack of direct correlation between BDEs and cyanobacterial populations. This was also supported by a within-sponge analysis of chl a and BDEs, since high levels of compounds were found in the choanosome of the sponge, whereas chl a and cyanobacterial contents were minimal. Our data suggest that the relationship between the levels of BDEs in D. granulosa and its photosynthetic symbionts is more complex than expected. Variation in the levels of secondary metabolites and symbionts seems to be related at a population scale, but unrelated at an individual scale.

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New chlorinated peptides from the tropical marine sponge Dysidea sp.

Cited by 23 publications

References 23 publications

Marine natural products

Marine natural products

Two novel alkaloids from the South China Sea marine sponge Dysidea sp.

Effects of depth and light on secondary metabolites and cyanobacterial symbionts of the sponge Dysidea granulosa

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