New chlorinated diphenyl ethers and xanthones from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001

Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

“…α-Glucosidase inhibitors demonstrated a large clinical importance in the treatment of type II diabetes, and this therapeutic class is mainly sustained by acarbose, miglitol, and voglibose, the 3 of them being derived from natural products [5][6][7]. Despite the close structural homologies between these clinically-approved inhibitors (carbasugars and iminosugars), polyphenolics pertaining to typical lichen metabolite series were repeatedly reported to exert promising α-glucosidase inhibitory activities: depsides [8], depsidones [9,10], diphenylethers [11], fungal xanthones [11], terphenylquinones, and pulvinic acid derivatives [12].…”

A comprehensive review on xanthone derivatives as α-glucosidase inhibitors

“…Oxygenated and prenylated xanthones are not restricted to the Garcinia species. A wide variety of derivatives have been isolated from other natural sources, which inhibitory effects against aglucosidase activity are depicted in Table 6 [41,43,47,50,51,53]. (Table 7).…”

“…Moreover, the inhibitory and binding mechanisms of 1,3-dihydroxyxanthone 25 and 1,3,7-trihydroxyxanthone 50 toward yeast's a-glucosidase activity were elucidated by experimental and docking studies, which indicate a noncompetitive type of inhibition for both xanthones, with loss of a-helix within the secondary structure of a-glucosidase, an important feature for the inhibitory process [58]. Furthermore, a synergistic effect of these two compounds were observed, suggesting that there may exist Table 6 Inhibitory effect of isolated xanthones 50, 65, 69, 81, 127 and 146e187 from the roots of Cudrania tricuspidata [43], stem of Securidaca inappendiculata [50], twigs of Maclura fruticosa [47], root barks of Cratoxylum cochinchinense [41], cultures of Aspergillus versicolor [53], deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 [51] on…”

Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins

“…Numerous reports can be found in the literature that illustrate the use of high-resolution tandem mass spectrometry (MS/MS) for the characterization of proteins [46][47][48][49], identification of peptide [50][51][52], untargeted screening of lipids [53], investigation of rhamnogalacturonan II pectin [54], and quantification of transfucosylation products for manufacturing biomimetic human milk oligosaccharides [55]. Other investigations varied from the synthesis of diarylethene fluorescence probes with a methylquinoline moiety [56], analysis of intermediates produced in the sulfamethoxazole photodegradation process [57], identification of isopropylphenol oxidation products [58], analysis of carotenoids in citrus [59], and chemical structure confirmation of phenolic compounds [60] to a wide range of bioanalytical applications using electrospray ionization (ESI) [61][62][63][64][65][66][67]. This literature review emphasizes both the versatility of ESI-ITMS as an analytical tool and the novelty of our BPA adsorption/desorption study uniquely with TiO 2 nanoparticles or milk proteins.…”