New chiral α-ketoimine-Pd(II) complexes and their anticancer activity

Gutiérrez, Daniela; Bernès, Syl­vain; Hernández, Guadalupe; Portillo, Oscar; Moreno, Gloria E.; Sharma, Manoj; Sharma, Pankaj; Tolentino, Rey Gutiérrez

doi:10.1080/00958972.2015.1084618

Cited by 10 publications

(5 citation statements)

References 30 publications

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“…4 times more cytotoxic than 2a . Several chiral palladium( ii ) derivatives with antitumor effects have been reported, 89–96 but only a few include a biological comparison of enantio- or diastereoisomers. 64,94–96 One of the most potent in vitro anticancer agents among them is trans -[1-menthyl-4-ethyl-1,2,4-triazol-5-ylidene] 2 Pd(OCOCF 3 ) 2 (IC 50 = 0.5–0.7 μM in MCF-7 and 2.3–2.6 μM in HeLa 96 ), with their two enantiomers showing nearly equal activity.…”

Section: Anti-proliferative Studiesmentioning

confidence: 99%

“…4 times more cytotoxic than 2a. Several chiral palladium(II) derivatives with antitumor effects have been reported, [89][90][91][92][93][94][95][96] but only a few include a biological comparison of enantio-or diastereoisomers. 94 To the best of our knowledge, the chirality influence of Pd(II) compounds on cytotoxicity has only been reported before in 1,2-bis-(1H-benzimidazol-2-yl)-1,2-ethanediol containing Pd(II) enantiomers, with (Λ)-being 2 times less active than the (Δ)-enantiomer in the MDA-MB231 and OVCAR-8 cell lines.…”

Section: Anti-proliferative Studiesmentioning

confidence: 99%

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Stereoselective synthesis of oxime containing Pd(ii) compounds: highly effective, selective and stereo-regulated cytotoxicity against carcinogenic PC-3 cells

et al. 2022

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Section: Anti-proliferative Studiesmentioning

confidence: 99%

Section: Anti-proliferative Studiesmentioning

confidence: 99%

Stereoselective synthesis of oxime containing Pd(ii) compounds: highly effective, selective and stereo-regulated cytotoxicity against carcinogenic PC-3 cells

et al. 2022

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“…Due to the analogous complex formation of Pt (II) and Pd (II), much effort has been devoted to developing palladium derivatives as anticancer supramolecular drugs [ 125 ]. However, compared to platinum anticancer drugs, most palladium supermolecules are less toxic to cancer cells, which is due to the instability of the palladium supermolecules, leading to the hydrolysis of the palladium supermolecules before they reach their pharmacological action target.…”

Section: Imidazole-based Supermolecules As Medicinal Agentsmentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

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The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.

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“…It was not possible to obtain a monocrystal of complex 19, however the crystal data of 18 showed that α-ketoimine 16 is a bidentate ligand and Pd(II) displayed a square-planar coordination geometry. In the case of 16, the conjugation of imine and carbonyl double bonds with the aromatic systems and the substitution of vicinal C1 and C2 by pyridil rings implied that the ligand adopted a gauche conformation [17].…”

Section: Chiral Pd(ii) Complexesmentioning

confidence: 99%

Chiral Mono- and α-Diimines and Their Pd(II) Complexes with Anticancer Activity

Hernández¹,

Gutiérrez²,

Moreno³

et al. 2020

Stability and Applications of Coordination Compounds

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The aim of this review is to provide mainly an outlook of the synthesis and characterization of chiral mono-and α-diimines ligands and their Pd(II) complexes carried out in our group in the last few years. Some other issues with simple chiral imines synthesized in our lab are also outlined. The report includes details about their versatile coordination patterns, biological activity in cancer cell lines, and engaging properties in different fields, such as materials science.

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New chiral α-ketoimine-Pd(II) complexes and their anticancer activity

Cited by 10 publications

References 30 publications

Stereoselective synthesis of oxime containing Pd(ii) compounds: highly effective, selective and stereo-regulated cytotoxicity against carcinogenic PC-3 cells

Stereoselective synthesis of oxime containing Pd(ii) compounds: highly effective, selective and stereo-regulated cytotoxicity against carcinogenic PC-3 cells

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Chiral Mono- and α-Diimines and Their Pd(II) Complexes with Anticancer Activity

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