New challenges in point of care electrochemical detection of clinical biomarkers

Campuzano, Susana; Pedrero, Marı́a; Yáñez‐Sedeño, Paloma; Pingarrón, José M.

doi:10.1016/j.snb.2021.130349

Cited by 91 publications

(58 citation statements)

References 94 publications

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“…Electrochemical sensors meet the main requirements of POCT, such as sensitivity, selectivity, ease of handling, affordability, disposability, stability, and flexibility. Electrochemical biosensors, which can be miniaturized, facilitate work with real samples in small volumes (μL-nL) without any pretreatment and versatility due to multiple sensor arrays, and show advantages compared to optical biosensors when used in POC devices [ 69 ].…”

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

“…Moreover, since electrochemical biosensors can be easily combined with digital signal readout, smartphone-based integrated systems for simultaneous detection of biomolecules, including DA, have been developed ( Figure 5 ). They allow real onsite measurement of DA, which can immediately be shared with the clinician [ 69 ]. The systems usually consist of a disposable sensor with a graphene-modified electrode, a coin-size detector, and a smartphone equipped with application software.…”

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

“…Recently, Yu et al have reported achieving a turn-on visual DA assay-based ratio metric fluorescence paper microchip coupled with a smartphone-assisted portable detection device for POC testing (POCT) [ 62 ]. Moreover, The role of the rapid improvement of smartphone cameras in optical POC sensing should also be considered [ 69 ]. This supports the DA detection strategy trend based on the use of smartphones for portable, rapid, and accurate POCT [ 71 , 72 ].…”

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

“…To ensure POCT’s usefulness to clinicians, future research [ 74 ], despite focusing on the analytical and technical performances of a test, should also tackle the aspects relating to the clinical utility and risks [ 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. Moreover, in the case of smartphone-connected POCT devices, the issues related to data sensitivity, including privacy and protection against theft and medical advice, should be addressed [ 69 ].…”

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

“…Biosensors 2021, 11, x FOR PEER REVIEW 10 of 14 risks[75][76][77][78][79][80][81][82][83]. Moreover, in the case of smartphone-connected POCT devices, the issues related to data sensitivity, including privacy and protection against theft and medical advice, should be addressed[69].…”

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confidence: 99%

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Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

2021

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Parkinson’s disease (PD) is a neurodegenerative disease in which the neurotransmitter dopamine (DA) depletes due to the progressive loss of nigrostriatal neurons. Therefore, DA measurement might be a useful diagnostic tool for targeting the early stages of PD, as well as helping to optimize DA replacement therapy. Moreover, DA sensing appears to be a useful analytical tool in complex biological systems in PD studies. To support the feasibility of this concept, this mini-review explores the currently developed graphene-based biosensors dedicated to DA detection. We discuss various graphene modifications designed for high-performance DA sensing electrodes alongside their analytical performances and interference studies, which we listed based on their limit of detection in biological samples. Moreover, graphene-based biosensors for optical DA detection are also presented herein. Regarding clinical relevance, we explored the development trends of graphene-based electrochemical sensing of DA as they relate to point-of-care testing suitable for the site-of-location diagnostics needed for personalized PD management. In this field, the biosensors are developed into smartphone-connected systems for intelligent disease management. However, we highlighted that the focus should be on the clinical utility rather than analytical and technical performance.

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Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

Section: Challenges and Perspectives Towards Poc Diagnostics Of Damentioning

confidence: 99%

mentioning

confidence: 99%

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Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

2021

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Biosensors as a Principal Tool for Bioremediation Monitoring

Singh¹,

Thakur²,

Dhanjal³

et al. 2023

Genomics Approach to Bioremediation

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Unraveling the Potential of a Nanostructured Tungsten–Tungsten Oxide Thin Film Electrode as a Bioresorbable Multichemical Wound Healing Monitor

Fernandes,

Loukopoulos,

Smets

et al. 2024

Adv Materials Technologies

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Recent advancements in wearable technology have led to a new era of intelligent wound dressings capable of monitoring vital healing biomarkers. While a significant leap from traditional gauze dressings, these innovations still necessitate periodic removal and disposal. Bioresorbable electrochemical sensors have emerged as a promising and sustainable solution, offering continuous monitoring of critical wound healing biomarkers in real‐time and in situ, followed by their full physiological resorption. The current challenge lies in the susceptibility of metallic electrodes to harsh electrolytic biofluids, hindering the development of viable transient electrochemical sensors. This study pioneers a bioresorbable electrochemical material and unique architecture comprising engineered sputtered tungsten (W) plus tungsten oxide (WOx) thin films, taking advantage of their high catalytic activity and uniquely gradual biodissolution. While a bare W film electrode detached from the wafer substrate within 5 hours of soaking, an annealed W‐WOx electrode showcases a notable electrochemical stability at body temperature, for up to several days. The latter reliably senses multiple analytes during 24‐hour room‐temperature tests. These findings underscore the potential of annealed W plus WOx electrodes in future bioresorbable wound management systems.

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New challenges in point of care electrochemical detection of clinical biomarkers

Cited by 91 publications

References 94 publications

Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

Using Graphene-Based Biosensors to Detect Dopamine for Efficient Parkinson’s Disease Diagnostics

Biosensors as a Principal Tool for Bioremediation Monitoring

Unraveling the Potential of a Nanostructured Tungsten–Tungsten Oxide Thin Film Electrode as a Bioresorbable Multichemical Wound Healing Monitor

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