New cephalosporins in development pipelines

Klaubert, Dieter H.; Essery, J. M.; Barrett, John

doi:10.1517/13543784.3.2.133

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Cephalosporins1

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2013

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Cited by 4 publications

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“…As a way of improving activity against the notoriously impermeable pathogen Pseudomonas aeruginosa, some compounds have been made with the aim of exploiting the tonB-dependent iron uptake mechanism by incorporating a catechol or catechol-like group. 7,8 No catechol-bearing b-lactam has yet completed clinical trials but the approach is nevertheless an interesting one.…”

Section: Cephalosporinsmentioning

confidence: 99%

The renewed challenge of antibacterial chemotherapy†

Niccolai¹,

Tarsi²,

Thomas³

1997

Chem. Commun.

149

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We are currently witnessing a dramatic and alarming increase in the incidence of bacterial infections resistant to most common antibiotics. In this article, we examine briefly the background to this situation, and the mechanisms both of antibacterial action and bacterial resistance. Following this introduction is a discussion of the evolution of the various antibacterial classes and of the current approaches being adopted to keep at bay the threat of a return to a preantibiotic era.

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Section: Cephalosporinsmentioning

confidence: 99%