New Cembranes from the Soft Coral <i>Sarcophyton</i> Species

Iwagawa, Tetsuo; Nakashima, Ryozo; Takayama, Keita; Okamura, Hiroaki; Nakatani, Munehiro; Doe, Matsumi; Shibata, Kozo

doi:10.1021/np9900066

Cited by 19 publications

(12 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, sarcophytol T (23), was isolated from the same species by Konig and his coworker [14]. From the soft coral Sarcophyton sp., studies have led to the identification of two new cembranes, epoxysartone B (24), and sartone E (25) [15]. Naturally occurring cembranes (26)(27)(28)(29) have been isolated from Sarcophyton sp.…”

Section: Isopropyl Cembranesmentioning

confidence: 99%

See 1 more Smart Citation

Cembrane Diterpenes Chemistry and Biological Properties

Yang¹,

Zhou²,

Lin³

et al. 2012

COC

View full text Add to dashboard Cite

Cembrane-type diterpenoids are a large and structurally varied group of natural products isolated from both terrestrial and marine organisms. The present paper reviews all the metabolites of cembrane diterpenes, reported up to 2010. The natural products discussed in this review can be divided into several different structural families featuring a variety of ring sizes and oxidation patterns. The currently known biological activities will be presented as well.

show abstract

Section: Isopropyl Cembranesmentioning

confidence: 99%

“…Six novel 13-membered carbocyclic cembranoids, named sartol acetate B (621) [15], sarcotol (622), sarcotol acetate (623), sarcotal acetate (624) [177], and two isomers (625, 626) from an unidentified Sarcophyton species [178].…”

Section: -Membered Carbocyclic Cembranoidsmentioning

confidence: 99%

Cembrane Diterpenes Chemistry and Biological Properties

Yang¹,

Zhou²,

Lin³

et al. 2012

COC

View full text Add to dashboard Cite

show abstract

“…The E-type stereochemistry of one trisubstituted carboncarbon double bond and the trisubstituted epoxide in 2 was indicated by the chemical shifts observed for the methyl signals in the 13 C NMR spectrum [δ 18.3 (q), 17.1 (q)]. 16,17 The E-geometry for ∆ 3 (4) was determined on the basis of no ROESY correlation between H-3 and H 2 -18. The relative configurations at C-7 and C-8 remain undefined.…”

Section: By Hr-esims {[M＋na]mentioning

confidence: 99%

Four New Cembrane Diterpenes from the Hainan Soft Coral Lobophytum sp.

2008

View full text Add to dashboard Cite

Four new cembrane diterpenes, 19-hydroxy-sarcocrassolide (1), 18-deacetyldeepoxy lobolide (2), 13-hydroxy-sinularial A (3) and 16-hydroxy-sinulariol C (4), along with four related known compounds (5-8), were isolated from the Hainan soft coral Lobophytum sp. Their structures, including relative stereochemistry, were elucidated by detailed analyses of spectroscopic data and by comparison with the data reported in literature.

show abstract

“…The soft coral Sarcophyton is a good source of different structures of diterpenes of cembrane type, sesquiterpenes, steroids, fatty acids and amino acids (Jia et al, 2006, Lan et al, 2007. Soft corals synthesize terpenoids as compounds used for chemical defense to avoid predatory fishes which attack their soft bodies (Iwagawa et al, 1999). So, many secondary metabolites isolated from soft corals have been proved to possess many different biological activities such as anti-microbial, anti-fungal, anti-tumor, anti-viral and antiinflammatory (Wei et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates

El-Ayouty¹,

Abdelhameed²,

Habib³

et al. 2021

Records of Pharmaceutical and Biomedical Sciences

View full text Add to dashboard Cite

Truthfully, natural products have been the principal productive source of advancing new drugs. The broad aim of this work was to conduct a phytochemical and biological study of the Red Sea soft coral Sarcophyton glaucum, Family: Alcyoniidae collected from Red Sea at the Egyptian coasts. The phytochemical investigation from the soft coral S. glaucum led to the isolation of ten compounds including: palmitic acid (1), stearic acid (2), (24S)-24-methyl cholesterol (3), batyl alcohol (4), heptadecanoic acid pentadecyl ester (5), sarcophine ( 6), (+)-7α, 8βdihydroxydeepoxysarcophine (7), uracil (8), thymine (9) and a ceramide (10). As cancer is one of the most hazardous factors threatening the human life, in this study the potential in-vitro cytotoxicity of the soft coral S. glaucum extract and three marine isolates were measured against HepG2 and MCF7 using Sulphorhodamine-B (SRB) assay and all of the tested samples showed a good cytotoxic activities against both hepatic and breast cancer. The extract of S. glaucum was tested also against the protozoan parasite Leishmania donovani, using pentamidine and amphotericin B as controls and showed antileishmanial activity.

show abstract

New Cembranes from the Soft Coral Sarcophyton Species

Abstract: Three new cembranes, including one with a 13-membered carbocyclic ring, have been isolated from the soft coral Sarcophyton sp.

Cited by 19 publications

References 4 publications

Cembrane Diterpenes Chemistry and Biological Properties

Cembrane Diterpenes Chemistry and Biological Properties

Four New Cembrane Diterpenes from the Hainan Soft Coral Lobophytum sp.

Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates

Contact Info

Product

Resources

About