New Carboxamides and a New Polyketide from the Sponge-Derived Fungus Arthrinium sp. SCSIO 41421

She, Jianglian; Chen, Yi; Ye, Yuxiu; Lin, Xiuping; Yang, Bin; Xiao, Jiangjian; Liu, Yonghong; Zhou, Xuefeng

doi:10.3390/md20080475

Cited by 7 publications

(7 citation statements)

References 25 publications

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“…The nuclear magnetic resonance (NMR) spectra of the toxin were obtained using a Bruker AVANCE III HD 600 spectrometer operating at 600 MHz for 1 H NMR and 151 MHz for 13 C NMR. Mass spectra were recorded on a Bruker MiXis TOF‐QII mass spectrometer (Bruker, Billerica, MA, USA) 15 . The structure of the toxin was identified by detailed NMR and MS data, as well as by comparison with data reported in the literature.…”

Section: Methodsmentioning

confidence: 99%

“…Mass spectra were recorded on a Bruker MiXis TOF-QII mass spectrometer (Bruker, Billerica, MA, USA). 15 The structure of the toxin was identified by detailed NMR and MS data, as well as by comparison with data reported in the literature.…”

Section: Structural Identification Of P 'Gingeri' Toxinmentioning

confidence: 99%

“…The P. fluorescens group produces many antifungal metabolites, including 2,4‐diacetylphloroglucinol (DAPG), pyoluteorin, which cause brown spots on A. bisporus , 15 as well as monoacetylresorcinol (MAPG), phenazine, phenazine‐1‐carboxylic acid, pyoluteorin, and pyrrolizin 17,18 . However, the exact biotoxins produced by P .…”

Section: Introductionmentioning

confidence: 99%

“…To date, the only conclusive finding regarding the toxin of P. 'gingeri' is that it does not produce tolaasin. 14 The P. fluorescens group produces many antifungal metabolites, including 2,4-diacetylphloroglucinol (DAPG), pyoluteorin, which cause brown spots on A. bisporus, 15 as well as monoacetylresorcinol (MAPG), phenazine, phenazine-1-carboxylic acid, pyoluteorin, and pyrrolizin. 17,18 However, the exact biotoxins produced by P. 'gingeri' and their potential pathogenic functions are still unknown, despite the species posing a significant risk to A. bisporus production.…”

Section: Introductionmentioning

confidence: 99%

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Ginger blotches on Agaricus bisporus due to monoacetylphloroglucinol production by the pathogen Pseudomonas ‘gingeri’

Huang,

Liang,

Wang

et al. 2023

Pest Management Science

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BackgroundAgaricus bisporus is the most widely cultivated and consumed mushroom worldwide. Pseudomonas ‘gingeri’ is the only pathogenic causative agent of ginger blotch in A. bisporus. Current research on mushroom pathogenic biotoxins is limited to P. tolaasii, which causes brown blotch, while understanding of P. ‘gingeri’ is lacking. Therefore, identifying the toxins produced by P. ‘gingeri’ and evaluating their toxicity on A. bisporus is essential for understanding its pathogenic mechanisms.ResultsA pathogenic bacterium isolated from fruiting bodies of A. bisporus with ginger blotch was identified as P. ‘gingeri’, and its main toxin identified as 2',4',6'‐trihydroxyacetophenone monohydrate, also known as monoacetylphloroglucinol (MAPG). Its first known extraction from a mushroom pathogen is reported here. MAPG at 250 μg/mL significantly inhibited the host's mycelial growth, increased branching, caused the structure to become dense and resulted in folds appearing on the surface. An MAPG concentration of 750 μg/mL MAPG leds to mycelial death. P. ‘gingeri’ had high MAPG production in medium containing 0.1 mol/L of either glucose and mannitol (4.30 μg/mL and 1.85 μg/mL, respectively), and mycelia were inhibited by 69.6% and 41.1%, respectively. The MAPG content was significantly lower in other carbon source media.ConclusionThis work first provides a detailed description of the structure and virulence of the P. ‘gingeri’ biotoxin, which has implications for understanding its pathogenic mechanism and for exploring precise control strategies for A. bisporus ginger blotch disease, such as the development of MAPG inhibitory factors.This article is protected by copyright. All rights reserved.

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Section: Methodsmentioning

confidence: 99%

Section: Structural Identification Of P 'Gingeri' Toxinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ginger blotches on Agaricus bisporus due to monoacetylphloroglucinol production by the pathogen Pseudomonas ‘gingeri’

Huang,

Liang,

Wang

et al. 2023

Pest Management Science

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“…SCSIO 41421. Preliminary bioactivity screening and molecular docking analysis revealed that compound 448 exhibited obvious enzyme inhibitory activity against AChE, with an inhibitory rate of 79.4% at 50 μg/mL [ 93 ].…”

Section: New Mnps From the Beibu Gulfmentioning

confidence: 99%

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

et al. 2023

Self Cite

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Marine natural products (MNPs) play an important role in the discovery and development of new drugs. The Beibu Gulf of South China Sea harbors four representative marine ecosystems, including coral reefs, mangroves, seaweed beds, and coastal wetlands, which are rich in underexplored marine biological resources that produce a plethora of diversified MNPs. In our ongoing efforts to discover novel and biologically active MNPs from the Beibu Gulf, we provide a systematic overview of the sources, chemical structures, and bioactive properties of a total of 477 new MNPs derived from the Beibu Gulf, citing 133 references and covering the literature from the first report in November 2003 up to September 2022. These reviewed MNPs were structurally classified into polyketides (43%), terpenoids (40%), nitrogen-containing compounds (12%), and glucosides (5%), which mainly originated from microorganisms (52%) and macroorganisms (48%). Notably, they were predominantly found with cytotoxic, antibacterial, and anti-inflammatory activities. This review will shed light on these untapped Beibu Gulf-derived MNPs as promising lead compounds for the development of new drugs.

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Secondary metabolites from the endophytic fungus Cladosporium sp. ZLM-6

Zhang,

Zheng,

Chu

et al. 2023

Biochemical Systematics and Ecology

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New Carboxamides and a New Polyketide from the Sponge-Derived Fungus Arthrinium sp. SCSIO 41421

Cited by 7 publications

References 25 publications

Ginger blotches on Agaricus bisporus due to monoacetylphloroglucinol production by the pathogen Pseudomonas ‘gingeri’

Ginger blotches on Agaricus bisporus due to monoacetylphloroglucinol production by the pathogen Pseudomonas ‘gingeri’

Marine Natural Products from the Beibu Gulf: Sources, Chemistry, and Bioactivities

Secondary metabolites from the endophytic fungus Cladosporium sp. ZLM-6

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