New Carbene Donor for Biocatalysis: Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridyltriazoles
Satyajit Roy,
Yining Wang,
Xinyi Zhao
et al.
Abstract:Hemoproteins have recently emerged as powerful biocatalysts for new-to-nature carbene transfer reactions. Despite this progress, these strategies have remained largely limited to diazo-based carbene precursor reagents. Here, we report the development of a biocatalytic strategy for the stereoselective construction of pyridine-functionalized cyclopropanes via hemoprotein-mediated activation of pyridyl triazoles (PyTz) as stable and readily accessible carbene sources. This method enables the asymmetric cyclopropa… Show more
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