New cancer cases in France in 2015 attributable to infectious agents: a systematic review and meta-analysis

Shield, Kevin D.; Micallef, Claire Marant; Martel, Catherine de; Heard, Isabelle; Mégraud, Françis; Plummer, Martyn; Vignat, Jérôme; Bray, Freddie; Soerjomataram, Isabelle

doi:10.1007/s10654-017-0334-z

Cited by 39 publications

(19 citation statements)

References 79 publications

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“…The estimates in our study are limited by scarcity of local data, especially in low-income countries. To allow for meaningful comparisons, precise estimates can and should be made by individual countries using all available sources of data, 31,32 and we hope that our approach for calculating attributable fractions can serve as a useful and standardised model. Periodical assessments of repre sentative case-series of cancer in sentinel sites with high-quality cancer registries could assist with long-term monitoring of trends in the burden of infection-related cancers.…”

Section: Resultsmentioning

confidence: 99%

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

Martel

Georges

Bray

et al. 2020

The Lancet Global Health

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988

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Background Infectious pathogens are strong and modifiable causes of cancer. The aim of this study was to improve estimates of the global and regional burden of infection-attributable cancers to inform research priorities and facilitate prevention efforts. Methods We used the GLOBOCAN 2018 database of cancer incidence and mortality rates and estimated the attributable fractions and global incidence for specific anatomical cancer sites, subsites, or histological subtypes known to be associated with ten infectious pathogens classified as human carcinogens. We calculated absolute numbers and age-standardised incidence rates (ASIR) of infection-attributable cancers at the country level. Estimates were stratified for sex, age group, and country, and were aggregated according to geographical regions and World Bank income groups. Findings We found that, for 2018, an estimated 2•2 million infection-attributable cancer cases were diagnosed worldwide, corresponding to an infection-attributable ASIR of 25•0 cases per 100 000 person-years. Primary causes were Helicobacter pylori (810 000 cases, ASIR 8•7 cases per 100 000 person-years), human papillomavirus (690 000, 8•0), hepatitis B virus (360 000, 4•1) and hepatitis C virus (160 000, 1•7). Infection-attributable ASIR was highest in eastern Asia (37•9 cases per 100 000 person-years) and sub-Saharan Africa (33•1), and lowest in northern Europe (13•6) and western Asia (13•8). China accounted for a third of worldwide cancer cases attributable to infection, driven by high ASIR of H pylori (15•6) and hepatitis B virus (11•7) infection. The cancer burden attributed to human papillomavirus showed the clearest relationship with country income level (from ASIR of 6•9 cases per 100 000 personyears in high-income countries to 16•1 in low-income countries). Interpretation Infection-attributable cancer incidence, in addition to the absolute number of cases, allows for refined geographic analyses and identification of populations with a high infection-associated cancer burden. When cancer prevention is largely considered in a non-communicable disease context, there is a crucial need for resources directed towards cancer prevention programmes that target infection, particularly in high-risk populations. Such interventions can markedly reduce the increasing cancer burden and associated mortality.

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Section: Resultsmentioning

confidence: 99%

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

Martel

Georges

Bray

et al. 2020

The Lancet Global Health

Self Cite

1,370

988

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“…We still performed a complementary analysis to estimate the number of potentially HPV-related cancers identified through our study that would actually be related to HPV. We used PAF values available from the most recent French study in the literature [ 20 ]. However, we used aggregated PAF values for the group of vulva and vagina cancers as well as for HNCs due to the lack of data availability and transposability, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Results have thus to be interpreted taking into account that, among vulva and vaginal cancers, vagina cancers are the rarest but associated with the highest PAF value (70% versus 15%) [ 21 ]. Among HNCs, oropharyngeal cancers are more common than oral cancers, and are associated to a higher PAF value (30% versus 4%) [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…e . with at least 100 observed new cases per year [ 20 , 21 ]. Patients were selected within the PMSI according to a list of ICD-10 codes corresponding to codes of cancers for which at least a fraction is known to be related to HPV ( i .…”

Section: Methodsmentioning

confidence: 99%

“…From a literature review, Shield et al . study has been identified as the most suitable source of data, since it provides the most recent PAF values obtained in France, for all cancer locations assessed in the present study [ 20 ]. It should be noticed that PAF value was aggregated for vulva and vaginal cancers, which lead to the conduct of the complementary analysis on this gathered group.…”

Section: Methodsmentioning

confidence: 99%

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Epidemiological and economic burden of potentially HPV-related cancers in France

Abramowitz¹,

Guily²,

Moyal‐Barracco³

et al. 2018

PLoS ONE

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Human papillomaviruses (HPV) infection is now known to be responsible for almost all cervical cancers, and for a substantial fraction of Head and Neck cancers (HNCs). However, comprehensive epidemiological and economic data is lacking in France, especially for rarer potentially HPV-related cancers, which include anal, vulvar and vaginal cancers. Using the national comprehensive database of French public and private hospital information (PMSI), we assessed prevalence and incidence of patients with in-hospital diagnosis for potentially HPV-related cancers in 2013, and estimated costs related to their management over a 3-year period after diagnosis in France. Concerning female genital cancers, 7,597, 1,491 and 748 women were hospitalized for cervical, vulvar and vaginal cancer in 2013, respectively, with 3,120, 522 and 323 of them being new cases. A total of 4,153 patients were hospitalized for anal cancer in 2013, including 1,661 new cases. For HNCs, 8,794 and 14,730 patients were hospitalized for oral and oropharyngeal cancer in 2013, respectively; 3,619 and 6,808 were new cases. Within the 3 years after cancer diagnosis, the average cost of hospital care per patient varied from €28 K for anal cancer to €41 K for oral cancer. Most expenditures were related to hospital care, before outpatient care and disability allowance; they were concentrated in the first year of care. The total economic burden associated with HPV-potentially related cancers was about €511 M for the French National Health Insurance over a 3 years period (2011 to 2013), ranging from €8 M for vaginal cancer to €222 M for oropharyngeal cancer. This study reported the most up-to-date epidemiological and economic data on potentially HPV-related cancers in France. These results may be used to evaluate the potential impact of new preventive strategies, namely the generalized organized screening of cervical cancer and the nine-valent HPV vaccine, indicated in the prevention of cervical, vaginal, vulvar and anal cancers.

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Cancers Attributable to Infections in the US in 2017

Volesky-Avellaneda,

Morais,

Walter

et al. 2023

JAMA Oncol

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ImportanceInfections are largely modifiable causes of cancer. However, there remains untapped potential for preventing and treating carcinogenic infections in the US.ObjectiveTo estimate the percentage and number of incident cancers attributable to infections in the US among adults and children for the most recent year cancer incidence data were available (2017).Data SourcesA literature search from 1946 onward was performed in MEDLINE on January 6, 2023, to obtain the data required to calculate population attributable fractions for 31 infection-cancer pairs. National Health and Nutrition Examination Survey data were used to estimate the population prevalence of hepatitis B and C viruses and Helicobacter pylori.Study SelectionStudies conducted in the US or other Western countries were selected according to specific infection-cancer criteria.Data Extraction and SynthesisData from 128 studies were meta-analyzed to obtain the magnitude of an infection-cancer association or prevalence of the infection within cancer cells.Main Outcomes and MeasuresThe proportion of cancer incidence attributable to 8 infections.ResultsOf the 1 666 102 cancers diagnosed in 2017 among individuals aged 20 years or older in the US, 71 485 (4.3%; 95% CI, 3.1%-5.3%) were attributable to infections. Human papillomavirus (n = 38 230) was responsible for the most cancers, followed by H pylori (n = 10 624), hepatitis C virus (n = 9006), Epstein-Barr virus (n = 7581), hepatitis B virus (n = 2310), Merkel cell polyomavirus (n = 2000), Kaposi sarcoma–associated herpesvirus (n = 1075), and human T-cell lymphotropic virus type 1 (n = 659). Cancers with the most infection-attributable cases were cervical (human papillomavirus; n = 12 829), gastric (H pylori and Epstein-Barr virus; n = 12 565), oropharynx (human papillomavirus; n = 12 430), and hepatocellular carcinoma (hepatitis B and C viruses; n = 10 017). The burden of infection-attributable cancers as a proportion of total cancer incidence ranged from 9.6% (95% CI, 9.2%-10.0%) for women aged 20 to 34 years to 3.2% (95% CI, 2.4%-3.8%) for women aged 65 years or older and from 6.1% (95% CI, 5.2%-7.0%) for men aged 20 to 34 years to 3.3% (95% CI, 1.9%-4.4%) for men aged 65 years or older. Among those aged 19 years or younger, 2.2% (95% CI, 1.3%-3.0%) of cancers diagnosed in 2017 were attributable to Epstein-Barr virus.Conclusions and RelevanceInfections were estimated to be responsible for 4.3% of cancers diagnosed among adults in the US in 2017 and, therefore, represent an important target for cancer prevention efforts.

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New cancer cases in France in 2015 attributable to infectious agents: a systematic review and meta-analysis

Cited by 39 publications

References 79 publications

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis

Epidemiological and economic burden of potentially HPV-related cancers in France

Cancers Attributable to Infections in the US in 2017

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