New bis-N9-(methylphenylmethyl)purine derivatives: Synthesis and antitumor activity

Kode, Nageswara; Chen, Liying; Murthy, Devangachinta; Adewumi, Dare; Phadtare, Shashikant

doi:10.1016/j.ejmech.2006.10.017

Cited by 28 publications

(13 citation statements)

References 10 publications

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“…During the last decades,c arbocyclic nucleosides have received considerable attention due to their enormous biological activity and their use as therapeutic agents for treatment of HIV, [1] hepatitis [2] and cancer [3] (Figure 1). As congeners of naturally occurring nucleosides,c arbanucleosides act as nucleoside reverse transcriptase inhibitors and reveal an increased stability against phosphorylases and phosphotransferases.…”

mentioning

confidence: 99%

Enantioselective and Regiodivergent Addition of Purines to Terminal Allenes: Synthesis of Abacavir

Thieme

Breit

2017

Angew Chem Int Ed

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The rhodium-catalyzed atom-economic asymmetric N-selective intermolecular addition of purine derivatives to terminal allenes is reported. Branched allylic purines were obtained in high yields, regioselectivity and outstanding enantioselectivity utilizing a Rh/Josiphos catalyst. Conversely, linear selective allylation of purines could be realized in good to excellent regio- and E/Z-selectivity with a Pd/dppf catalyst system. Furthermore, the new methodology was applied to a straightforward asymmetric synthesis of carbocyclic nucleoside abacavir.

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mentioning

confidence: 99%

Enantioselective and Regiodivergent Addition of Purines to Terminal Allenes: Synthesis of Abacavir

Thieme

Breit

2017

Angew Chem Int Ed

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“…Ligand 1 was synthesized by reported procedure and recrystallized from dichloromethane. Crystal refinement data confirmed that 1 [C 18 H 12 Cl 2 N 8 ] crystallized in monoclinic space group C 2/ c .…”

Section: Figurementioning

confidence: 99%

“…[9] This topic was recently addressed by Collins and co-workers, who demonstrated the efficacy of silver ions against Gram-negative bacteria. [10] Ligand 1 was synthesized by reported procedure [11] and recrystallized from dichloromethane. Crystal refinement data confirmed that 1 [C 18 H 12 Cl 2 N 8 ]c rystallized in monoclinic space group C2/c.C arefuli nvestigationd isclosed that the lattice was primarily stabilized by Cl···Cl and CH-p interactions, in addition to H8-N1 hydrogen bonding interactions (Figure S1 c, Supporting Information).…”

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confidence: 99%

Luminescent Silver–Purine Double Helicate: Synthesis, Self‐Assembly and Antibacterial Action

et al. 2016

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How would you describe your research? We have designed al uminescent silver-purine helical coordination complex and studied its antibacterial activity against both Gram-positive and Gram-negative bacteria. The MIC values indicate that the complex exhibits significantly better activity against Gram-negative bacteria, especially against E. coli.L uminescent properties of this complex were used to study its bacterial cell uptake with the help of fluorescence and scanning electron microscopy methods. This study suggests that silver-purine double helical complexes could be used as potential antibacterial agents.

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“…The compounds that reduced the growth of the cell lines to 32% or less (negative number indicate kills) were considered in vitro active 32 . Compounds 3c and 4n satisfied pre-determined threshold growth inhibition criteria and further selected for NCI full panel five-dose assay at 10-fold dilutions of five different concentrations (0.01, 0.1, 1, 10 and 100 mM) Dose response curves obtained from the NCI's in vitro disease-oriented human tumor cells line of compounds 3c and 4n on nine cancer disease at five concentrations were shown in Figures 3 and 4.…”

Section: Anticancer Activity Evaluationmentioning

confidence: 99%

Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives

Demirayak¹,

Yurttaş²

2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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The synthesis of some new pyrazino[1,2-a]benzimidazole derivatives and investigation of their anticancer activities were aimed in this work. Thus, 2-acetylbenzimidazole was reacted with appropriate a-bromoacetophenones and potassium carbonate in acetone to give 2-(2-acetyl-1H-benzimidazol-1-yl)-1-phenylethanone derivatives (3a-d). These diketone compounds were reacted with varied benzylamines in acetic acid to obtain 2-benzyl-1-methylidene-3-aryl-1,2-dihydropyrazino[1,2-a]benzimidazole derivatives (4a-t). The structures of the obtained compounds were elucidated by using IR, 1

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New bis-N9-(methylphenylmethyl)purine derivatives: Synthesis and antitumor activity

Cited by 28 publications

References 10 publications

Enantioselective and Regiodivergent Addition of Purines to Terminal Allenes: Synthesis of Abacavir

Enantioselective and Regiodivergent Addition of Purines to Terminal Allenes: Synthesis of Abacavir

Luminescent Silver–Purine Double Helicate: Synthesis, Self‐Assembly and Antibacterial Action

Synthesis and anticancer activity of some 1,2,3-trisubstituted pyrazinobenzimidazole derivatives

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