New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915

Liu, Shun-Zhi; Yan, Xiaojun; Tang, Xixiang; Lin, Junjie; Qiu, Ying-Kun

doi:10.3390/md16120483

Cited by 20 publications

(25 citation statements)

References 14 publications

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“…In summary, our chemical analysis of a sponge-derived fungus of the genus Fusarium led to the identification of two new and three known aromatic polyketides (1 and 2, and 3-5, respectively) and two sesquiterpenes (6 and 7). Although secondary metabolites of Fusarium were extensively studied in the past [26][27][28], it is still possible to obtain additional new compounds, implying the existence of unstudied Fusarium species capable of producing unknown metabolites in marine symbiotic environments. Interestingly, 4 and its 5-O-methylated congener were previously reported from the Australian marine crinoid Comatula rotalaria [20].…”

Section: Resultsmentioning

confidence: 99%

Two new aromatic polyketides from a sponge-derived Fusarium

Sibero¹,

Zhou²,

Fukaya³

et al. 2019

Beilstein J. Org. Chem.

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In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A (1) and B (2) and five known compounds (3–7) were isolated from sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected from an Indonesian sponge Xestospongia sp. The structures of these compounds were determined by the analysis of NMR and MS spectroscopic data. The NMR assignment of 1 was assisted by DFT-based theoretical chemical shift calculation. Compound 2 showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC of 125 µg/mL while 1 was not active.

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Section: Resultsmentioning

confidence: 99%

Two new aromatic polyketides from a sponge-derived Fusarium

Sibero¹,

Zhou²,

Fukaya³

et al. 2019

Beilstein J. Org. Chem.

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“…Interestingly some Fusarium sp. [29] contain equisetin, the enantiomeric homolog of phomasetin, which possesses totally opposite stereochemistry in all chiral centers. Such compounds have been proposed to be mixed biosynthesis products of PKS and NRPS pathways [23].…”

Section: Discussionmentioning

confidence: 99%

Pyrenosetins A–C, New Decalinoylspirotetramic Acid Derivatives Isolated by Bioactivity-Based Molecular Networking from the Seaweed-Derived Fungus Pyrenochaetopsis sp. FVE-001

Fan

Dewapriya

et al. 2020

Marine Drugs

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Marine algae represent a prolific source of filamentous fungi for bioprospecting. In continuation of our search for new anticancer leads from fungi derived from the brown alga Fucus vesiculosus, an endophytic Pyrenochaetopsis sp. FVE-001 was selected for an in-depth chemical analysis. The crude fungal extract inhibited several cancer cell lines in vitro, and the highest anticancer activity was tracked to its CHCl3–soluble portion. A bioactivity-based molecular networking approach was applied to C18-SPE fractions of the CHCl3 subextract to predict the bioactivity scores of metabolites in the fractions and to aid targeted purification of anticancer metabolites. This approach led to a rapid isolation of three new decalinoylspirotetramic acid derivatives, pyrenosetins A–C (1–3) and the known decalin tetramic acid phomasetin (4). The structures of the compounds were elucidated by extensive NMR, HR-ESIMS, FT-IR spectroscopy, [α]D and Mosher’s ester method. Compounds 1 and 2 showed high anticancer activity against malignant melanoma cell line A-375 (IC50 values 2.8 and 6.3 μM, respectively), in line with the bioactivity predictions. This is the first study focusing on secondary metabolites of a marine-derived Pyrenochaetopsis sp. and the second investigation performed on the member of the genus Pyrenochaetopsis.

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“…Marine-derived fungi are important resources of structurally and biologically diverse secondary metabolites in drug discovery [1,2,3,4,5,6]. A series of novel marine natural compounds have been isolated from marine-derived fungi of Aspergillus fumigatus strains, such as E -β- trans -5,8,11-trihydroxybergamot-9-ene and β- trans -2β,5,15-trihydroxybergamot-10-ene [7], diketopiperazines [8,9], indole alkaloids [10], fumigaclavine C [11], fumiquinazoline K [12], and gliotoxin analogues [13].…”

Section: Introductionmentioning

confidence: 99%

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

Han

Wang

et al. 2019

Marine Drugs

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Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds.

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New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915

Cited by 20 publications

References 14 publications

Two new aromatic polyketides from a sponge-derived Fusarium

Two new aromatic polyketides from a sponge-derived Fusarium

Pyrenosetins A–C, New Decalinoylspirotetramic Acid Derivatives Isolated by Bioactivity-Based Molecular Networking from the Seaweed-Derived Fungus Pyrenochaetopsis sp. FVE-001

Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

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