New Biotechnological Forms of Nutritional Supplements Aimed at Improving the Gut Disbiosis and Their Clinical Appraisal

Abstract

The present study deals with some new biotechnological forms of nutritional supplements and their effectiveness in helping people with gut disbiosis. We have developed four different nutritional supplements to prevent and treat gastrointestinal diseases. The general characteristic of each supplement is given. Nutritional supplement 1 contains modified sorbents to neutralize bacterial endotoxins. Nutritional supplement 2 includes live microencapsulated forms of Bifidobacterium and Lactobacillus aimed at sustaining the immune system. Supplement 3 combines bacterial metabiotics, which absorb endotoxins, thus improving intestinal biocenosis. Nutritional supplement 4 is a plant-based product that enhances the colonization of friendly microbiota and has a protective and anti-inflammatory effect by inhibiting yeast fungi and pathogenic bacteria growth. Ten volunteers aged from 33 to 72 were involved in the clinical trials. They took these four nutritional supplements per os. The supplement intake scheme and treatment duration have been tested, analyzed, and approved. The patients' biochemical, hematological and immunological blood properties, as well as their fecal sugur, feces occult blood, and coprogram were tested before and after the treatment period. The results proved the efficiency of the developed nutritional supplements in improving gut disbiosis.