New biomaterial as a promising alternative to silicone breast implants

Lim, G. T.; Valente, Stephanie A.; Hart-Spicer, Cherie R.; Evancho-Chapman, M. Michelle; Puskás, Judit E.; Horne, Walter I.; Schmidt, Steven

doi:10.1016/j.jmbbm.2013.01.025

Cited by 34 publications

(7 citation statements)

References 28 publications

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“…In recent years, the research group of Puskas et al developed a new one‐pot synthesis route for making arborescent polymers . Arborescent polyisobutylene ( arb PIB), which they produced via living carbocationic polymerization, is suitable for human implantation, especially for breast reconstruction after breast cancer surgery . Compared with traditional silicon‐based materials, arb PIB has higher mechanical strength, less liquid leakage, and better biocompatibility, allowing new cells to grow on the surface of arb PIB material …”

Section: Introductionmentioning

confidence: 99%

Predicting Average Molecular Weights and Branching Level for Self‐Condensing Vinyl Copolymerization in a CSTR

Buren

Zhao

Puskás

et al. 2018

Macro Reaction Engineering

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A continuous stirred‐tank reactor (CSTR) model is developed to produce arborescent polyisobutylene via carbocationic copolymerization of isobutylene and inimer using multidimensional method of moments. The model is used to predict dynamic changes in average branching level (Bkin) and number‐average and weight‐average molecular weights (trueM¯normaln and trueM¯normalw). Simulations of this self‐condensing vinyl copolymerization (SCVCP) show a tendency toward higher polydispersity and higher Bkin compared to batch reactor simulations conducted using the same recipes and residence times. At high inimer feed concentration and/or long residence time, the model predicts that a CSTR does not reach steady‐state operation due to trueM¯normalw increasing toward infinity. There is a narrow operating range in which inimer feed concentrations can be adjusted to achieve a desired steady‐state trueM¯normalw. If SCVCP is to be conducted in a CSTR, it will be important to ensure that residence times and inimer feed concentrations are selected within the stable operating window.

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Section: Introductionmentioning

confidence: 99%

Predicting Average Molecular Weights and Branching Level for Self‐Condensing Vinyl Copolymerization in a CSTR

Buren

Zhao

Puskás

et al. 2018

Macro Reaction Engineering

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“…None of the modern polymers that are suitable for use as biostable medical implants has low enough Young's modulus. Although a recently proposed arborescent block copolymer, TPE1, has a Young's modulus (0.6 MPa) in the appropriate range [23], the need for new longterm biostable polymers with low Young's modulus for long-term, soft-tissue implants remains significant.…”

Section: Introductionmentioning

confidence: 99%

Plasma mediated protein immobilisation enhances the vascular compatibility of polyurethane with tissue matched mechanical properties

et al. 2017

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Polyurethanes are a diverse class of polymers, with independently tunable mechanical and biodegradation properties making them a versatile platform material for biomedical implants. Previous iterations have failed to adequately embody appropriate mechanical and biological properties, particularly for vascular medicine where strength, compliance and multifaceted biocompatibility are required. We have synthesized a new polyurethane formulation with finely tuned mechanical properties, combining high strength and extensibility with a low Young's modulus. Additional cross-linking during synthesis enhanced stability and limits leaching. Under cyclic testing, hysteresis was minimal following completion of the initial cycles, indicating the robustness of the material. Building on this platform, we used plasma immersion ion implantation to activate the polymer surface and functionalized it with recombinant human tropoelastin. With tropoelastin covalently bound to the surface, human coronary endothelial cells showed improved attachment and proliferation. In the presence of heparinized whole blood, tropoelastin-coated polyurethane showed very low thrombogenicity in both static and flow conditions. Using this formulation, we synthesized robust, elastic prototype conduits which easily retained multiple sutures and were successfully implanted in a pilot rat aortic interposition model. We have thus created an elastic, strong biomaterial platform, functionalized with an important regulator of vascular biology, with the potential for further evaluation as a new synthetic graft material.

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“…Sensor material (silicon chip, used for making microelectronic sensors), Beads (Arbomatrix™, a block copolymer of polyisobutylene and polystyrene with a branched polyisobutylene core, used for sensor packaging and coating) (Puskas and Chen, 2004; Puskas et al, 2005; Teck Lim et al, 2013), and Control (shunting tubing end, silicone rubber, Medtronic #41101, Goleta, CA) were used for implantation ( Fig. 2 A-C ).…”

Section: Methodsmentioning

confidence: 99%

Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating

Yang

Charif

Puskás

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix™ that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix™ was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix™ is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix™ has already been shown to be an excellent protective coating for new ICP monitoring chip.

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New biomaterial as a promising alternative to silicone breast implants

Cited by 34 publications

References 28 publications

Predicting Average Molecular Weights and Branching Level for Self‐Condensing Vinyl Copolymerization in a CSTR

Predicting Average Molecular Weights and Branching Level for Self‐Condensing Vinyl Copolymerization in a CSTR

Plasma mediated protein immobilisation enhances the vascular compatibility of polyurethane with tissue matched mechanical properties

Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating

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