New biomarkers in the risk stratification of patients with suspected acute myocardial infarction

Rogers, Bret; Newby, L. Kristin

doi:10.1007/s11886-002-0071-z

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2003

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“…Myocardial infarction (MI) is a major cause of death in men and women, especially in western society. , However, myocardial necrosis remains difficult to diagnose definitively without specialty reagents and optimized assays. , Present biomarkers often take several hours to appear in the serum. It remains possible that the victims of massive MI have been previously suffering minor events that have gone undiagnosed.…”

Section: Introductionmentioning

confidence: 99%

Processing of Serum Proteins Underlies the Mass Spectral Fingerprinting of Myocardial Infarction

Marshall¹,

Kupchak²,

Zhu³

et al. 2003

J. Proteome Res.

209

338

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The MALDI-TOF spectra of peptides from the sera of normal and myocardial infarction patients produced patterns that provided an accurate diagnostic of MI. In myocardial infarction, the spectral pattern originated from the cleavage of complement C3 alpha chain to release the C3f peptide and cleavage of fibrinogen to release peptide A. The fibrinogen peptide A and complement C3f peptide were in turn progressively truncated by aminopeptidases to produce two families of fragments that formed the characteristic spectral pattern of MI. Time course and inhibitor studies demonstrated that the peptide patterns in the serum reflect the balance of disease-specific-protease and aminopeptidase activity ex vivo.

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