New biomarkers improve stratification of patients with melanoma

Craig, Sarah; Virós, Amaya

doi:10.1111/bjd.18555

Cited by 1 publication

(1 citation statement)

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“…Melanoma can occur in all individuals of all ages, occurring more often in men, and the mortality rate of male patients is higher than that of females (5). Melanoma is stratified as follows: Grade I, tumor cells are confined to the epidermis above the basement membrane; Grade II, tumor cells have broken through the basement membrane and have invaded the dermal papillary layer; Grade III, the tumor cells fill the papillary layer of the dermis and invade further downwards, but have not reached the reticular layer of the dermis; Grade IV, the tumor cells have invaded the dermal reticular layer; and Grade V, the tumor cells have passed through the dermal reticular layer and invaded the subcutaneous fat layer (6). There are generally no obvious symptoms of occurrence during the earlier stages.…”

Section: Introductionmentioning

confidence: 99%

Low expression of SEMA4D as a potential predictive molecular marker of poor survival in patients with melanoma combined with liver cancer

et al. 2023

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This study explored the correlation between semaphorin 4D (SEMA4D) and the prognosis and survival time of patients with melanoma combined with liver cancer. A total of 272 patients were recruited, and clinical and follow-up data were recorded. The expression levels of SEMA4D and SEMA3B were determined. Pearson's χ 2 test and Spearman's rank correlation coefficient were used to analyze the relationship between prognosis and the assessed parameters of melanoma patients. Univariate and multivariate Logistic regression and Cox proportional risk regression analyses were used for further analysis. Additionally, receiver operating characteristic curve and survival curves of subjects were plotted. The Pearson's χ 2 test showed that the prognosis of melanoma patients was significantly correlated with age, tumor grade, and decreased SEMA4D expression. Additionally, Spearman's correlation coefficient analysis showed that age, tumor grade, and SEMA4D expression were significantly correlated with prognosis. Univariate logistic regression analysis showed that age and tumor grade, and SEMA4D expression, were significantly correlated with prognosis. Older patients, a higher tumor grade, and lower SEMA4D expression were associated with a poorer prognosis. Multivariate logistic regression analysis showed that older patients had a poorer prognosis, and patients with lower SEMA4D expression levels had a significantly worse prognosis than patients with higher SEMA4D expression levels. Kaplan-Meier analysis showed that the survival time of older patients was lower than that of the younger patients. The survival times of patients with lower SEMA4D expression levels were significantly lower than that of patients with higher SEMA4D expression levels. Multivariate Cox regression analysis showed that the survival time of older patients was lower than that of younger patients. The survival time of melanoma patients with low SEMA4D expression was significantly lower than that of patients with higher SEMA4D expression. SEMA4D was significantly associated with melanoma, and lower SEMA4D expression was associated with a poorer survival prognosis in melanoma patients.

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Section: Introductionmentioning

confidence: 99%