New Bioactive Polyphenols fromTheobromagrandiflorum(“Cupuaçu”)

Yang, Hui; Protiva, Petr; Cui, Bo; C, Ma; Baggett, Scott; Hequet,; Mori, Scott A.; Weinstein, I. Bernard; Kennelly, Edward J.

doi:10.1021/np034002j

Cited by 75 publications

(66 citation statements)

References 19 publications

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“…39) 8-O-Glucuronides of isocutellarein and hypolaetin possess higher anti-DPPH activity than kempferol. 40) Luteolin was also found to be an excellent inhibitor of Fe 3ϩ -catalyzed liposome peroxidation, superior in comparison to TBHQ. 41) All investigated Stachys extracts exhibited substantial antioxidant activity.…”

Section: )mentioning

confidence: 97%

Antioxidant Activity of Four Endemic Stachys Taxa

Kukić

Petrović

Niketić

2006

Biological & Pharmaceutical Bulletin

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Methanol extracts of aerial flowering parts of four endemic Stachys taxa: S. anisochila VIS. et PANČIĆ, S. beckeana DÖRFLER & HAYEK, S. plumosa GRISEB. and S. alpina L. ssp. dinarica MURB. were investigated on their antioxidant activity. The extracts were studied for total antioxidant activity (TAA), along with 1,1-diphenyl 2-picryl hydrazyl (DPPH) and OH radical scavenging activity, and lipid peroxidation (LP). High correlations between total phenolics content, TAA and scavenging DPPH radical indicate that polyphenols are the main antioxidants. All Stachys extracts, with the exception of S. plumosa, exhibited high anti-DPPH activity (IC 50 Ͻ50 m mg/ml). In concentration range from 6.25 to 50 m mg/ml, all extracts scavenged OH radical above 40%, with maximal inhibitions for S. anisochila, S. alpina ssp. dinarica and S. beckeana extracts of 50.22%, 50.94% and 64.97%, respectively. Only S. plumosa extract achieved maximal activity of 60.67% at 100 m mg/ml. As for LP, IC 50 values for S. beckeana and S. alpina ssp. dinarica extracts were 25.07 and 49.00 m mg/ml, respectively, while S. anisochila and S. plumosa extracts did not reach 50% of LP inhibition.

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Section: )mentioning

confidence: 97%

Antioxidant Activity of Four Endemic Stachys Taxa

Kukić

Petrović

Niketić

2006

Biological & Pharmaceutical Bulletin

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“…Moreover, it is important to highlight that despite the presence of lower amounts of isoscutellarein derivatives as compared to those of phenylethanoid glycosides, these can also be key components on the ethnopharmacological effects of the plant. Indeed, for the last decades, isoscutellarein derivatives have also been described to exert important beneficial activities as antiviral, antioxidant, cytotoxic, antinociceptive, anti-inflammatory and inhibitory activity against osteoclastogenesis (Kupeli, Sahin, Yesilada, Calis, & Ezer, 2007;Nagai, Miyaichi, Tomimori, Suzuki, & Yamada, 1992;Yang et al, 2003;Yoon, Jeong, Hwang, Ryu, & Kim, 2007).…”

Section: Quantification Of Phenolic Compounds In Peelmentioning

confidence: 99%

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Pereira

Domingues

Silva

et al. 2012

Food Research International

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Lamium album L. is an edible plant which is consumed raw or cooked, in particular in the Mediterranean and surrounding areas. It is also consumed as tea infusions and as a main component of food supplements, because of its pharmacological effects. Despite being consumed by humans for centuries, the chemical composition of L. album L. is far from being understood. In this study, a purified ethanolic extract (PEEL) was prepared and further analyzed by high performance liquid chromatography and electrospray mass spectrometry. Overall, verbascoside accounted for approximately half of the phenolic content of the extract, but this also contained other bioactive phenolic compounds herein detected for the first time in the genus, namely isoscutellarein derivatives. The latter included isoscutellarein-7-O-allosyl(1 →2)glucoside, its O-methyl derivative, three acetyl derivatives of isoscutellarein-Oallosyl glucoside and one acetylated form of O-methylisoscutellarein-7-O-allosyl(1 →2)glucoside. From those, the main isoscutellarein derivative was assigned to isoscutellarein-7-O-(6-O-acetyl-β-allosyl)(1→2)-β-glucoside, as confirmed by NMR. Altogether, isoscutellarein derivatives accounted for almost 30% of PEEL phenolics. Since verbascoside and isoscutellarein derivatives are main components of L. album L. ethanolic extract, their possible association to the health benefits of the plant is discussed.

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“…21 Também possui dois flavonoides glicosídicos específicos (teograndinas I e II) e flavonoides antioxidantes (catequina, epicatequina, quercetina e kaempferol). 22 O óleo de castanha do Brasil apresenta compostos como ácidos palmítico, esteárico, linoleico, mirístico, dentre outros, que também se caracterizam como substâncias interessantes para aplicação tópica cutânea. 23,24 Assim, o objetivo deste trabalho foi preparar diferentes formulações de teosferas, a fim de selecionar um sistema adequado para encapsulação de dapsona visando sua aplicação tópica cutânea.…”

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Desenvolvimento e caracterização de nanopartículas lipídicas destinadas à aplicação tópica de dapsona

Santos¹,

Pereira²,

Bender³

et al. 2012

Quím. Nova

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Recebido em 26/10/11; aceito em 3/3/12; publicado na web em 15/6/12 DEVELOPMENT AND CHARACTERIZATION OF LIPID NANOPARTICLES FOR DAPSONE TOPICAL APPLICATION. In this work, theospheres (innovative lipid nanoparticles) were prepared by the high pressure homogenization technique using different surfactants for dapsone encapsulation. Mean particle size ranged from 105 to 153 nm and negative zeta potentials were obtained for all theosphere formulations. Atomic force microscopy images confirmed the spherical shape of theospheres. The HPLC method used to determine dapsone-loaded theospheres was selective, linear, exact and precise. The entrapment efficiency of dapsone was 91.4%. Theospheres provided controlled release of idebenone (52.7 ± 1.6%) in comparison to the free drug (103.1 ± 1.9%).Keywords: lipid nanoparticles; dapsone; in vitro release study. INTRODUÇÃOA dapsona (4-4'diaminofenilsulfona) (Figura 1) é uma sulfona que possui dupla atividade -antimicrobiana e anti-inflamatória/imunomoduladora. Devido a esta dupla ação, a dapsona é utilizada como terapia única ou em conjunto com outros fármacos no tratamento de doenças provocadas por patógenos (a exemplo de hanseníase e pneumonia por Pneumocystis jiroveci) e doenças inflamatórias crô-nicas, especialmente as dermatológicas.1 Adicionalmente, dapsona tem demonstrado ser eficiente na inibição de espécies reativas de oxigênio (ROS), mostrando-se tão eficaz quanto catalase na redução dos níveis de H 2 O 2 e tão potente quanto colchicina, benzoato e xantina na redução dos níveis de OH -em ensaios in vitro. 2Quando administrada por via oral, dapsona é metabolizada originando hidroxilaminas, responsáveis por efeitos adversos importantes como hemólise e metemoglobinemia. A hemólise caracteriza-se pela ruptura da membrana plasmática das hemácias levando ao rompimento destas células, enquanto a metemoglobinemia é uma condição em que a hemoglobina perde a capacidade de se ligar ao oxigênio e transportá-lo.3 Ambas as condições são observadas em todos os pacientes tratados com dapsona por via oral. Além disso, a administração sistêmica de dapsona reduz o tempo de meia-vida dos eritrócitos e pode levar à hemólise grave em pacientes que apresentam deficiência na enzima glicose-6-fosfato desidrogenase. Outros efeitos colaterais menos frequentes observados com este tratamento incluem reações idiossincráticas como agranulocitose, erupção cutânea, leucopenia, neuropatia periférica, além de sintomas neurológicos e gastrointestinais. 4 Estudos já demonstraram equivalência na atividade da dapsona aplicada topicamente (0,1; 0,5; 1; 5 e 10%) e sistemicamente (100 mg/ dia) na supressão de eritema cutâneo causado por radiação UVB em voluntários saudáveis.2 Assim, uma abordagem para reduzir os efeitos colaterais é a administração de dapsona diretamente na área afetada. A aplicação cutânea pode fornecer concentrações eficazes da dapsona no tecido alvo e reduzir a exposição sistêmica ao fármaco, 4 diminuindo a gravidade dos efeitos colaterais. Embora a administração tópica não seja ideal para o...

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New Bioactive Polyphenols fromTheobromagrandiflorum(“Cupuaçu”)

Cited by 75 publications

References 19 publications

Antioxidant Activity of Four Endemic Stachys Taxa

Antioxidant Activity of Four Endemic Stachys Taxa

Phenolic constituents of Lamium album: Focus on isoscutellarein derivatives

Desenvolvimento e caracterização de nanopartículas lipídicas destinadas à aplicação tópica de dapsona

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