2003
DOI: 10.1021/np034002j
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New Bioactive Polyphenols fromTheobromagrandiflorum(“Cupuaçu”)

Abstract: Activity-guided fractionation of Theobroma grandiflorum ("cupuaçu") seeds resulted in the identification of two new sulfated flavonoid glycosides, theograndins I (1) and II (2). In addition, nine known flavonoid antioxidants, (+)-catechin, (-)-epicatechin, isoscutellarein 8-O-beta-d-glucuronide, hypolaetin 8-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide, quercetin 3-O-beta-d-glucuronide 6' '-methyl ester, quercetin, kaempferol, and isoscutellarein 8-O-beta-d-glucuronide 6' '-methyl ester, were identif… Show more

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Cited by 75 publications
(66 citation statements)
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“…39) 8-O-Glucuronides of isocutellarein and hypolaetin possess higher anti-DPPH activity than kempferol. 40) Luteolin was also found to be an excellent inhibitor of Fe 3ϩ -catalyzed liposome peroxidation, superior in comparison to TBHQ. 41) All investigated Stachys extracts exhibited substantial antioxidant activity.…”
Section: )mentioning
confidence: 97%
“…39) 8-O-Glucuronides of isocutellarein and hypolaetin possess higher anti-DPPH activity than kempferol. 40) Luteolin was also found to be an excellent inhibitor of Fe 3ϩ -catalyzed liposome peroxidation, superior in comparison to TBHQ. 41) All investigated Stachys extracts exhibited substantial antioxidant activity.…”
Section: )mentioning
confidence: 97%
“…Moreover, it is important to highlight that despite the presence of lower amounts of isoscutellarein derivatives as compared to those of phenylethanoid glycosides, these can also be key components on the ethnopharmacological effects of the plant. Indeed, for the last decades, isoscutellarein derivatives have also been described to exert important beneficial activities as antiviral, antioxidant, cytotoxic, antinociceptive, anti-inflammatory and inhibitory activity against osteoclastogenesis (Kupeli, Sahin, Yesilada, Calis, & Ezer, 2007;Nagai, Miyaichi, Tomimori, Suzuki, & Yamada, 1992;Yang et al, 2003;Yoon, Jeong, Hwang, Ryu, & Kim, 2007).…”
Section: Quantification Of Phenolic Compounds In Peelmentioning
confidence: 99%
“…21 Também possui dois flavonoides glicosídicos específicos (teograndinas I e II) e flavonoides antioxidantes (catequina, epicatequina, quercetina e kaempferol). 22 O óleo de castanha do Brasil apresenta compostos como ácidos palmítico, esteárico, linoleico, mirístico, dentre outros, que também se caracterizam como substâncias interessantes para aplicação tópica cutânea. 23,24 Assim, o objetivo deste trabalho foi preparar diferentes formulações de teosferas, a fim de selecionar um sistema adequado para encapsulação de dapsona visando sua aplicação tópica cutânea.…”
Section: Introductionunclassified