New bioactivation mode for vascular prostheses made of Dacron® polyester

Bonzon, N.; Lefèbvre, F.; Ferre, N.; Daculsi, Guy; Rabaud, M.

doi:10.1016/0142-9612(95)99636-z

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…8 In fact, heparin and HS modulate the growth of several cell types such as endothelial and fibroblast cells when grown in the presence of heparin-binding growth factors. 9,10 Collagen is a major component of the ECM in many tissues, and is an important natural biomaterial in combination with other materials, being used in a variety of tissue-engineering applications such as vascular prostheses 11 and bioartificial organs. 12,13 A variety of cell types including fibroblasts, endothelial cells, and neutrophils have been shown to efficiently attach to, grow onto, and migrate along collagen matrices.…”

Section: Introductionmentioning

confidence: 99%

Heparin‐carrying polystyrene (HCPS)‐bound collagen substratum to immobilize heparin‐binding growth factors and to enhance cellular growth

Sato

Hattori

Saitō³

et al. 2001

J. Biomed. Mater. Res.

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Heparin-carrying polystyrene (HCPS), consisting of low molecular weight heparin chains linked to a synthetic polystyrene core, is able to attach to polymeric surfaces. In this study, HCPS has efficiently bound to collagen-coated micro-plates and collagen membranes thereby retaining the binding of heparin-binding growth factors, such as vascular endothelial growth factor (VEGF)(165) or fibroblast growth factor (FGF)-2. Both human skin fibroblast cells and human umbilical vein endothelial cells have shown a good adherence to both collagen- and HCPS-bound collagen substrata. The growth rate of the fibroblast cells on the HCPS-bound collagen substratum in the presence of low concentrations of FGF-2 is higher than on a collagen surface. The fibroblast cells grow at a significantly higher rate on the HCPS-bound collagen substratum retained with FGF-2. Similarly, the growth rate of the endothelial cells on the HCPS-bound collagen substrata in the presence of low concentrations of either FGF-2 or VEGF(165) is higher than on collagen. The endothelial cells also grow at a significantly higher rate on the HCPS-bound collagen substratum retained with either FGF-2 or VEGF(165). These results indicate that HCPS-bound collagen substrata with various bioactive heparin-binding molecules may provide novel biomaterials controlling cellular activities such as growth and differentiation.

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Section: Introductionmentioning

confidence: 99%

Heparin‐carrying polystyrene (HCPS)‐bound collagen substratum to immobilize heparin‐binding growth factors and to enhance cellular growth

Sato

Hattori

Saitō³

et al. 2001

J. Biomed. Mater. Res.

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“…It had structural and biological properties very close to the natural ECM and provided a good alternative for protein coatings on (small-diameter) vascular grafts. The same coating was also used by Bonzon et al (1995) on Dacron, who obtained an irreversible binding by covalently linking the components under mild chemical conditions. The resulting coating had a composition and 3D structure similar to the subendothelium, and provided bioactive properties suitable for the development of a vascular prosthesis.…”

Section: Extracellular Matrix Coatingsmentioning

confidence: 97%

Endothelialization of Small-Diameter Vascular Prostheses

Zijpp¹,

A.A.²,

Feijen³

2003

Archives of Physiology and Biochemistry

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In the field of arterial vascular reconstructions there is an increasing need for functional small-diameter artificial grafts (inner diameter < 6 mm). When autologous replacement vessels are not available, for example because of the bad condition of the vascular system in the patient, the surgeon has no other alternative than to implant a synthetic polymerbased vessel. After implantation the initial major problem concerning these vessels is the almost immediate occlusion, due to blood coagulation and platelet deposition, under the relatively low flow conditions. As the search for the perfect bio-inert polymer has not revealed a material with suitable properties for this application, improved performance of small-diameter artificial blood vessels is now being sought in the biological field. The poor blood-compatibility of an artificial vascular graft is not simply because of its coagulation-stimulating or platelet-activating properties, but more due to its inability to actively participate in the prevention of blood coagulation and platelet deposition. As these functions are naturally performed by endothelial cells, the utilization of these cells seems inevitable for the construction of a functional small-diameter artificial blood vessels. This review describes the current status of the use of endothelial cells to improve the performance of artificial vascular prostheses.

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“…10 -12 Polyethylene terephthalate (PET) is widely used for cell culturing (as Thermanox or Mylar), surgical suture material, or vascular grafts (as Dacron) due to its acceptable biocompatibility. [13][14][15] PET is inert and stable due to its high melting point of 245°C. Titanium 16 and its alloys are widely used as implant materials in orthopedics and dental applications, 17,18 and, due to its widely accepted biocompatibility; it is also used for soft tissue implants.…”

Section: Introductionmentioning

confidence: 99%

Fibroblast attachment to smooth and microtextured PET and thin cp‐Ti films

Jain

Recum

2003

J Biomedical Materials Res

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Improving the biological performance of engineered implants apposing interfacing tissues is a critical issue in Biomaterials Science and Engineering. Micromotion at the soft tissue-implant interface has been shown to sustain an inflammatory response. To eliminate micromotion, it is desirable to promote cellular and extracellular matrix adhesion to the implant surface. Surfaces are modified topographically or chemically to effect cellular adhesion and to influence cellular interactions and function. Previous studies have identified the specific topographical characteristics that appear to elicit cellular attachment. This in vitro study compares the independent effects of surface chemistry and topography on fibroblast-test specimen proximity. Titanium (Ti) was sputter-coated in stepwise, increasing thickness (20-350 nm) onto a series of either smooth or microtextured polyethylene terephthalate (PET), resulting in a stepwise change from a PET surface to a Ti surface. The series was evaluated in a 3-day fibroblast culture with transmission electron microscopy (TEM) for cell-test specimen proximity. Fibroblast proximity to the coverslip surface increases, as the Ti thickness increases, on either smooth or textured test specimens. Furthermore, fibroblasts were firmly attached to the ridge tops on the coated textured test specimens. Therefore, fibroblast apposition is strongly enhanced by microtextured surfaces and Ti rather than smooth surfaces and PET.

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New bioactivation mode for vascular prostheses made of Dacron® polyester

Cited by 22 publications

References 11 publications

Heparin‐carrying polystyrene (HCPS)‐bound collagen substratum to immobilize heparin‐binding growth factors and to enhance cellular growth

Heparin‐carrying polystyrene (HCPS)‐bound collagen substratum to immobilize heparin‐binding growth factors and to enhance cellular growth

Endothelialization of Small-Diameter Vascular Prostheses

Fibroblast attachment to smooth and microtextured PET and thin cp‐Ti films

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