New biaryl-chalcone derivatives of pregnenolone via Suzuki–Miyaura cross-coupling reaction. Synthesis, CYP17 hydroxylase inhibition activity, QSAR, and molecular docking study

Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction

“…The mixture was heated under reflux for 12-14 h. After cooling phase, water (5 mL) was added and the mixture was partitioned with ethyl acetate (3 × 10 mL) and the combined organic extracts which were washed with aqueous solution of 5% Na2CO3 (3 × 10 mL), and dried with sodium sulfate and then evaporated in vacuum. The residue was then filtered on a short SiO2 column using hexane: ethyl acetate (3:2, v:v) as eluent to get the desired product [26] (Scheme 1). …”

New Chalcone Derivatives as Anticancer and Antioxidant Agents: Synthesis, Molecular Docking Study and Biological Evaluation

“…Many synthesized chemical compounds have shown various biological activities [2][3][4][5][6][7][8][9]. Among those compounds, chalcones and their derivatives have received increasing attention from researchers because of their various activities, such as anti-bacterial [10][11][12], antifungal [13,14], anti-cancer [15][16][17], anti-Alzheimer [18,19], anti-inflammatory [20,21], and antioxidant [22][23][24], in addition to their importance in the industrial field [25][26][27].…”

Design, synthesis, and anti-hepatocellular carcinoma of thiopyrimidine/chalcone hybrids as dual STAT3/STAT5 inhibitors

“…25,26 As well, significant anticancer activity has been demonstrated in vitro for many synthetic chalcones. [27][28][29] To address these issues, we used molecular hybridization to design and synthesize new 2-thiopyrimidine-chalcone derivatives with an acetamide group as a linker (Fig. 1).…”

“…25,26 As well, significant anticancer activity has been demonstrated in vitro for many synthetic chalcones. 27–29…”