New benzothiazinone linked 1, 2, 4-triazoles: Design, synthesis, characterization, and evaluation of antitubercular activity

Kannampally, Ajmal; Gurubasavaraj, V Pujar; Arun, Kumar; Subhankar, P. Mandal; Singh, Manisha

doi:10.7324/japs.2021.110204

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“…These compounds are widely used in the treatment of various human diseases, including as anticonvulsant, vasorelaxant, antidiabetic, and antiarrhythmic agents. [43][44][45] In our study, five [1,4]-benzothiazin-3-one derivatives (4a-4e) were obtained, four of which were new. The synthesis involved S-H insertion with 2-aminobenzenethiol, followed by intramolecular cyclization.…”

Section: Resultsmentioning

confidence: 77%

The α-alkylation of carbonyl sulfoxonium ylides: studies and applications in the synthesis of new sulfur heterocycles

2023

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Section: Resultsmentioning

confidence: 77%

The α-alkylation of carbonyl sulfoxonium ylides: studies and applications in the synthesis of new sulfur heterocycles

2023

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A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole Derivatives

Rangaswamy,

Laddi

2024

AIA

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The present review aims to summarize the antitubercular profile of 1,2,4-triazole, one of the emerging entitled and most sought scaffold with a wide spectrum of biological and pharmacological activities. A systematic review of literature on ‘Heterocycles’, establishes the fact that 1,2,4-triazoles and their derivatives exhibit diverse activities. The 1,2,4-triazole core is found in therapeutically significant drugs and many new ones are in the pipeline. ‘Triazole pharmacophore’ has replaced the widely used ‘imidazole’ as ‘systemically integral azole’ by connecting synchronicity with serendipity. Triazoles are penetratingly studied as ‘diverse therapeutic agents’, due to the improved efficacy and reduced side effects. The extensive anthology of work carried out in the last two decades on 1,2,4-triazole moiety will provide imminent scope for the development of novel potential drugs having better efficacy selectivity and reduced toxicity.

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New benzothiazinone linked 1, 2, 4-triazoles: Design, synthesis, characterization, and evaluation of antitubercular activity

Cited by 2 publications

References 17 publications

The α-alkylation of carbonyl sulfoxonium ylides: studies and applications in the synthesis of new sulfur heterocycles

The α-alkylation of carbonyl sulfoxonium ylides: studies and applications in the synthesis of new sulfur heterocycles

A Review on Emerging Impact of Antitubercular Activity of 1,2,4-Triazole Derivatives

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