NEW AZO-SCHIFF BASE DERIVED WITH Ni(II), Co(II), Cu(II), Pd(II) AND Pt(II) COMPLEXES: PREPARATION, SPECTROSCOPIC INVESTIGATION, STRUCTURAL STUDIES AND BIOLOGICAL ACTIVITY

Abstract

The coordination ability of the azo-Schiff base 2-[1,5-Dimethyl-3-[2-(5-methyl-1H-indol-3-yl)-ethyl imino]-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylazo]-5-hydroxy-benzoic acid has been proven in complexation reactions with Co(II), Ni(II), Cu(II), Pd(II) and Pt(II) ions. The free ligand (LH) and its complexes were characterized using elemental analysis, determination of metal concentration, magnetic susceptibility, molar conductivity, FTIR, Uv-Vis, (1H, 13C) NMR spectra, mass spectra and thermal analysis (TGA). The results confirmed the coordination of the ligand through the nitrogen of the azomethine, Azo group (Azo) and the carboxylate ion with the metal ions. The activation thermodynamic parameters, such as ΔE*, ΔH * , ΔS * , ΔG * and K are calculated from the TGA curves using CoatsRedfern method. Hyper Chem-8 program has been used to predict structural geometries of compounds in the gas phase. The synthesized ligands and their metal complexes were screened for their biological activity against bacterial species, two Gram positive bacteria (Bacillus subtillis and Staphylococcus aureus) and two Gram negative bacteria (Escherichia coli and Pseudomonas aereuguinosa).

Synthesis, characterization, and biological activity of Schiff bases metal complexes

“…Furthermore, the magnetic moment of the Mn (II) (d5 ) complex was found to be 5.11 B.M., and the Cd and Hg complexes were found to be diamagnetic. All the above mentioned data correspond to a tetrahedral geometry . All the absorption bands were fully assigned in Table .…”

“…All the above mentioned data correspond to a tetrahedral geometry. [24] All the absorption bands were fully assigned in Table 3. The molar conductivity value of the complexes was consistent with 1:1 electrolytes of all complexes and non-electrolytes for Cr (III) and Fe (III) complexes.…”

A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes

“…Signals in the region 7-8.08 ppm due to aromatic protons. [35][36][37][38][39] The Schiff base (II)[ Figure 1(b)] exhibits signal at 5.3 ppm due to SH protons. It also exhibits resonance due to -CH2-protons around 3.8 and 1.1 ppm.…”

New Ni(II), Pd(II) and Pt(II) complexes coordinated to azo pyrazolone ligand with a potent anti‐tumor activity: Synthesis, characterization, DFT and DNA cleavage studies

“…[9] The biological activity of azo pyrazolones has been assigned to its scavenging activity against the harmful species of reactive oxygen and nitrogen. [10] Cancer has long been one of the most serious diseases menacing human health. Subsequently, discovering new compounds with potent anticancer activity is of ultimate important.…”