New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop

Abstract

From the methylene chloride/methanol extract of Cotinus coggygria Scop.heartwood one new aurone epoxide, 2,10-oxy-10-methoxysulfuretin (14), and one auronolignan (15), named cotinignan A, were isolated by silica gel column and semipreparative HPLC chromatography.

Bisaurones – enzymatic production and biological evaluation

“…40 Since both chalcone butein and aurone sulfuretin have been isolated (in our previous work) in high amounts from the Cotinus coggygria methylene chloride-methanol extract (Novakovic et al, 2019) it is assumed that similar oxidase enzyme is present in C. coggygria. 12 This is in accordance with the preposition of Maesane and coauthors that rare aurones could be produced naturally from widely distributed 2′-hydroxychalcones. 41 Additionally, the first laccase was found in 1883 by Joshida in Rhus vernicifera 42,43 and genus…”

“…It is a well known constituent of plants of genera Rhus 10 and Cotinus. 11,12 In the previous studies aurones, especially sulfuretin, exhibited wide range of biological activities. Shin et.…”

Anti-Inflammatory and Cytotoxic Potential of New Phenanthrenoids from Luzula sylvatica

“…The EtOAc, CH 2 Cl 2 and n-Hex fractions were the most active ones (with a decrease of 60 to 75% compared to control). Analysis of the EtOAc fraction by LC-MS, LC-MS 2 , and UV spectrometry, in comparison with standards, led to the characterisation of luteolin, as its major constituent, as well as 1,3-O-dicaffeoylglycerol (ananasate) [16][17][18] and 3',5,5',7-tetrahydroxyflavanone [19]. Thus, the activity of EtOAc fraction could be due to the presence of luteolin, a flavone known for its anti-inflammatory properties [20,21].…”

Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA

“…These compounds, except garbanzol, have already been isolated from Serbian C. coggygria in our previous work and the most abundant compounds by far were fustin and sulfuretin, isolated in amounts over 100 mg, while other compounds were isolated in the range of 2 to 10 mg (see the "Experimental" section). 9 Considering that oxidative stress causes DNA damage with the formation of MN, and with 10 isolated flavonoids-well-known antioxidants, 19 our idea was to examine these compounds by CBMN assay and determine their possible protective effect against chromosome aberrations in peripheral human lymphocytes.…”

“…Compounds 1-10 (comprising 4 flavonoid subclasses), that is, chalcone butein (1), aurone sulfuretin (2), auronolignan cotinignan A (3), and 7 flavanones, eriodictyol (4), taxifolin (5), butin (6), fustin (7), cis-methylfustin (8), fustin-3-O-gallate (9), and garbanzol (10) (Figures 1 and 2) were isolated from the heartwood of C. coggygria using silica gel column chromatography (CC) followed by preparative thin-layer chromatography (TLC) and semipreparative reversed-phase high-performance liquid chromatography (HPLC). These compounds, except garbanzol, have already been isolated from Serbian C. coggygria in our previous work and the most abundant compounds by far were fustin and sulfuretin, isolated in amounts over 100 mg, while other compounds were isolated in the range of 2 to 10 mg (see the "Experimental" section).…”