New Aspects on the Metabolic role of Intestinal Microbiota in the Development of Atherosclerosis

Drosos, Ioannis; Tavridou, Anna; Kolios, George

doi:10.1016/j.metabol.2015.01.007

Cited by 55 publications

(32 citation statements)

References 56 publications

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“…For example TMAO can be formed from other nutrients including choline (abundant in eggs) and carnitine (abundant in beef), which may explain the TMAO excretions after red meat (beef) intake. The substrates choline and L‐carnitine produce trimethylamine (TMA) by gut microbiota in the intestine and the gut microbiota‐derived TMA is subsequently converted into TMAO in the liver . In our study, fish consumption resulted in much higher TMAO concentrations compared to red meat consumption, which is consistent with previous results by Cho et al.…”

Section: Discussionsupporting

confidence: 92%

“…Fish is an important dietary protein source and oily fish is rich in long‐chain omega‐3 polyunsaturated fatty acids (PUFAs) . In epidemiological studies, greater intake of fish was reported to have associations with decreased risk of diseases such as cancer, cerebrovascular diseases, heart diseases, and diabetes . However, there are also some inconsistent findings in the literature .…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide

Yin

Gibbons

Rundle

et al. 2020

Molecular Nutrition Food Res

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Scope: Fish intake is reported to be associated with certain health benefits; however, accurate assessment of fish intake is still problematic. The objective of this study is to identify fish intake biomarkers and examine relationships with health parameters in a free-living population. Methods and results: In the NutriTech study, ten participants randomized into the fish group consume increasing quantities of fish for 3 days per week for 3 weeks. Urine is analyzed by NMR spectroscopy. Trimethylamine-N-oxide (TMAO), dimethylamine, and dimethyl sulfone are identified and display significant dose-response with intake (p < 0.05). Fish consumption yields a greater increase in urinary TMAO compared to red meat. Biomarker-derived fish intake is calculated in the National Adult Nutrition Survey cross-sectional study. However, the correlation between fish intake and TMAO (r = 0.148, p < 0.01) and that between fish intake and calculated fish intake (r = 0.142, p < 0.01) are poor. In addition, TMAO shows significantly positive correlation with serum insulin and insulin resistance in males and the relationship is more pronounced for males with high dietary fat intake. Conclusion: Urinary TMAO displays a strong dose-response relationship with fish intake; however, use of TMAO alone is insufficient to determine fish intake in a free-living population.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide

Yin

Gibbons

Rundle

et al. 2020

Molecular Nutrition Food Res

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show abstract

“…On the other hand, the role of gut microbes in regulating the immune system through metabolism-independent pathways has been identified (Brown and Hazen, 2015, Drosos et al, 2015). Therefore, to test the hypothesis that the impact of intestinal microbiota on atherosclerosis is via activation of B2 cells, we initially analyzed B2-cell populations in spleen and PVAT.…”

Section: Resultsmentioning

confidence: 99%

Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism

et al. 2016

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The relation between B2 cells and commensal microbes during atherosclerosis remains largely unexplored. Here we show that under hyperlipidemic conditions intestinal microbiota resulted in recruitment and ectopic activation of B2 cells in perivascular adipose tissue, followed by an increase in circulating IgG, promoting disease development. In contrast, disruption of the intestinal microbiota by a broad-spectrum antibiotic cocktail (AVNM) led to the attenuation of atherosclerosis by suppressing B2 cells, despite the persistence of serum lipid abnormalities. Furthermore, pharmacological depletion of B2 cells with an anti-B2-cell surface CD23 antibody also attenuated commensal microbe-induced atherosclerosis. Moreover, expression analysis of TLR-signaling-related genes in the activated B2 cell subsets, assessed using the Toll-Like Receptor Signaling Pathway RT2 Profiler PCR Array, confirmed activation of the B2-cell autoantibody-production axis, which was associated with an increased capacity of B2 cells to bind to intestinal microbiota. Together, our findings reveal the critical role of commensal microbe-specific activation of B2 cells in the development of atherogenesis through lipid metabolism-independent mechanisms.

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“…When homeostasis becomes unbalanced and microbial populations and functions are altered, the phenomenon is called dysbiosis. It has been directly associated [149][150][151] with the onset, progression and therapeutic response of multiple health conditions, including lung-associated disorders [152,153], obesity [154,155], diabetes [156,157], cardiovascular disease and atherosclerosis [158][159][160][161], chronic kidney disease [162][163][164], cancer [165][166][167], neurological and neuropsychiatric disorders [168][169][170][171], and, in the spirit of this review, IBD [172][173][174].…”

Section: Microbiome In Ibd: the Meta-paradigmmentioning

confidence: 96%

Systems biology in inflammatory bowel diseases: on the way to precision medicine

Dovrolis

Filidou

Kolios

2019

aog

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Inflammatory bowel diseases (IBD) are chronic and recurrent inflammatory disorders of the gastrointestinal tract. The elucidation of their etiopathology requires complex and multiple approaches. Systems biology has come to fulfill this need in approaching the pathogenetic mechanisms of IBD and its etiopathology, in a comprehensive way, by combining data from different scientific sources. In combination with bioinformatics and network medicine, it uses principles from computer science, mathematics, physics, chemistry, biology, medicine and computational tools to achieve its purposes. Systems biology utilizes scientific sources that provide data from omics studies (e.g., genomics, transcriptomics, etc.) and clinical observations, whose combined analysis leads to network formation and ultimately to a more integrative image of disease etiopathogenesis. In this review, we analyze the current literature on the methods and the tools utilized by systems biology in order to cover an innovative and exciting field: IBD-omics.

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New Aspects on the Metabolic role of Intestinal Microbiota in the Development of Atherosclerosis

Cited by 55 publications

References 56 publications

The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide

The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide

Commensal Microbe-specific Activation of B2 Cell Subsets Contributes to Atherosclerosis Development Independently of Lipid Metabolism

Systems biology in inflammatory bowel diseases: on the way to precision medicine

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